Detailed information of TA system TA232643

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 1487932..1488511
• Replicon: chromosome
• Accession: NZ_CP091066
• Organism: Staphylococcus aureus strain UMCG579

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: L1O91_RS07000
• Protein ID: WP_001025401.1
• Coordinates: 1488266..1488511 (-)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	1487932..1488297 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L1O91_RS06960 (1484675)	1484675..1485232	-	558	WP_000645042.1	DUF2815 family protein	-
L1O91_RS06965 (1485258)	1485258..1486424	-	1167	WP_000762547.1	DUF2800 domain-containing protein	-
L1O91_RS06970 (1486421)	1486421..1486783	-	363	WP_000985984.1	hypothetical protein	-
L1O91_RS06975 (1486798)	1486798..1487121	-	324	WP_257552433.1	TrmB family transcriptional regulator	-
L1O91_RS06980 (1487200)	1487200..1487361	-	162	WP_001285954.1	DUF1270 domain-containing protein	-
L1O91_RS06985 (1487374)	1487374..1487637	-	264	WP_001124160.1	helix-turn-helix domain-containing protein	-
L1O91_RS06990 (1487662)	1487662..1487877	-	216	WP_001097552.1	hypothetical protein	-
L1O91_RS06995 (1487932)	1487932..1488297	+	366	WP_001128433.1	hypothetical protein	Antitoxin
L1O91_RS07000 (1488266)	1488266..1488511	-	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
L1O91_RS07005 (1488567)	1488567..1488776	+	210	WP_000642492.1	hypothetical protein	-
L1O91_RS07010 (1488766)	1488766..1488909	-	144	WP_000939498.1	hypothetical protein	-
L1O91_RS07015 (1488938)	1488938..1489714	-	777	WP_001148544.1	Rha family transcriptional regulator	-
L1O91_RS07020 (1489728)	1489728..1489964	-	237	WP_001121027.1	helix-turn-helix transcriptional regulator	-
L1O91_RS07025 (1490116)	1490116..1490430	+	315	WP_000333630.1	helix-turn-helix transcriptional regulator	-
L1O91_RS07030 (1490443)	1490443..1490904	+	462	WP_000525004.1	hypothetical protein	-
L1O91_RS07035 (1490922)	1490922..1491356	+	435	WP_000755718.1	hypothetical protein	-
L1O91_RS07040 (1491385)	1491385..1491780	+	396	WP_000449655.1	hypothetical protein	-
L1O91_RS07045 (1491870)	1491870..1492016	+	147	WP_001795334.1	hypothetical protein	-
L1O91_RS07050 (1492013)	1492013..1492627	-	615	WP_000191466.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	dfrG	lukF-PV / lukS-PV	1444029..1511597	67568

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T232643 WP_001025401.1 NZ_CP091066:c1488511-1488266 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

>T232643 NZ_CP127849:2340-2615 [Escherichia coli]
ATGGAACTGAAGTGGACCAGTAAGGCGCTTTCTGATTTGGCGCGGTTATATGATTTTCTGGTGCTGGCCAGTAAACCTGC
GGCCGCCAGAACGGTGCAGTCCCTGACACAGGCTCCGGTCATTCTGTTAACTCATCCACGTATGGGGGAACAGTTATTTC
AGTTTGAACCCAGGGAAGTCAGACGGATTTTTGCTGGCGAGTACGAAATCCGTTACGAACTTACTGGCCAGACTATTTAT
GTATTGCGCCTGTGGCACACACGAGAAAACAGGTAG

Antitoxin

Nucleotide

• Length: 366 bp

>AT232643 NZ_CP091066:1487932-1488297 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin