Detailed information of TA system TA232633

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-rdlD/Ldr(toxin)
• Location: 3692510..3692732
• Replicon: chromosome
• Accession: NZ_CP091065
• Organism: Escherichia coli strain DOC14

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: S1E8T8
• Locus tag: L1123_RS18030
• Protein ID: WP_000141634.1
• Coordinates: 3692510..3692617 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	rdlD
Locus tag	-
Coordinates	3692666..3692732 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L1123_RS18005	3687763..3688491	-	729	WP_011310329.1	cellulose biosynthesis protein BcsQ	-
L1123_RS18010	3688527..3688715	-	189	WP_001063318.1	cellulose biosynthesis protein BcsR	-
L1123_RS18015	3688988..3690559	+	1572	WP_001204931.1	cellulose biosynthesis c-di-GMP-binding protein BcsE	-
L1123_RS18020	3690556..3690747	+	192	WP_000988308.1	cellulose biosynthesis protein BcsF	-
L1123_RS18025	3690744..3692423	+	1680	WP_000191622.1	cellulose biosynthesis protein BcsG	-
L1123_RS18030	3692510..3692617	-	108	WP_000141634.1	type I toxin-antitoxin system toxic polypeptide LdrD	Toxin
-	3692666..3692732	+	67	-	-	Antitoxin
L1123_RS18035	3693093..3694364	+	1272	WP_001295225.1	aromatic amino acid transport family protein	-
L1123_RS18040	3694394..3695398	-	1005	WP_000107012.1	dipeptide ABC transporter ATP-binding subunit DppF	-
L1123_RS18045	3695395..3696378	-	984	WP_001196486.1	dipeptide ABC transporter ATP-binding protein	-
L1123_RS18050	3696389..3697291	-	903	WP_000084677.1	dipeptide ABC transporter permease DppC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3916.72 Da
• Isoelectric Point: 9.0157

>T232633 WP_000141634.1 NZ_CP091065:c3692617-3692510 [Escherichia coli]
MTFAELGMAFWHDLAAPVIAGILASMIVNWLNKRK

Nucleotide

• Length: 108 bp

>T232633 NZ_CP127848:880155-880562 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin

Nucleotide

• Length: 67 bp

>AT232633 NZ_CP091065:3692666-3692732 [Escherichia coli]
GTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCTC

Structures

Toxin

• PDB: 5LBJ

Antitoxin