Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
| Location | 57419..58146 | Replicon | plasmid pKP29105-1 |
| Accession | NZ_CP091062 | ||
| Organism | Klebsiella pneumoniae strain KP29105 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | A0A7W3D9W1 |
| Locus tag | L1062_RS26835 | Protein ID | WP_011251285.1 |
| Coordinates | 57835..58146 (-) | Length | 104 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | L1062_RS26830 | Protein ID | WP_011251286.1 |
| Coordinates | 57419..57838 (-) | Length | 140 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| L1062_RS26800 (L1062_26800) | 52587..53057 | - | 471 | WP_048333570.1 | hypothetical protein | - |
| L1062_RS26805 (L1062_26805) | 53370..54005 | - | 636 | WP_223171879.1 | hypothetical protein | - |
| L1062_RS26810 (L1062_26810) | 54424..55044 | + | 621 | WP_223175004.1 | conjugative transfer protein MobI(A/C) | - |
| L1062_RS26815 (L1062_26815) | 55065..55853 | + | 789 | WP_040217257.1 | hypothetical protein | - |
| L1062_RS26820 (L1062_26820) | 55867..56232 | + | 366 | WP_048333448.1 | hypothetical protein | - |
| L1062_RS26825 (L1062_26825) | 56304..57272 | - | 969 | WP_086642568.1 | IS5 family transposase | - |
| L1062_RS26830 (L1062_26830) | 57419..57838 | - | 420 | WP_011251286.1 | helix-turn-helix domain-containing protein | Antitoxin |
| L1062_RS26835 (L1062_26835) | 57835..58146 | - | 312 | WP_011251285.1 | type II toxin-antitoxin system HigB family toxin | Toxin |
| L1062_RS26840 (L1062_26840) | 58351..58788 | - | 438 | Protein_58 | DDE-type integrase/transposase/recombinase | - |
| L1062_RS26845 (L1062_26845) | 58923..59620 | + | 698 | WP_223175001.1 | IS1-like element IS1A family transposase | - |
| L1062_RS26850 (L1062_26850) | 59622..60071 | + | 450 | WP_011251283.1 | thioredoxin fold domain-containing protein | - |
| L1062_RS26855 (L1062_26855) | 60088..60399 | + | 312 | WP_011251282.1 | hypothetical protein | - |
| L1062_RS26860 (L1062_26860) | 60413..60754 | + | 342 | WP_011251281.1 | hypothetical protein | - |
| L1062_RS26865 (L1062_26865) | 60814..61770 | + | 957 | WP_011251280.1 | DsbA family protein | - |
| L1062_RS26870 (L1062_26870) | 61887..62462 | + | 576 | WP_074424927.1 | hypothetical protein | - |
| L1062_RS26875 (L1062_26875) | 62570..63085 | + | 516 | WP_041937820.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Mobilizable plasmid | - | iroB / iroC / iroD / iroN / rmpA / iucA / iucB / iucC / iucD / iutA / rmpA2 | 1..229582 | 229582 | |
| - | inside | IScluster/Tn | - | - | 47298..59620 | 12322 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 104 a.a. Molecular weight: 12346.12 Da Isoelectric Point: 9.7248
>T232605 WP_011251285.1 NZ_CP091062:c58146-57835 [Klebsiella pneumoniae]
MHVISKEPFEEAAKRYPNDSLAIRALYRLVRETDFSSPAEMLTLIPSLDNFKYRNKWWVLDVGGNNLRVIAYINFVNKRF
YVKHIATHADYDKLTRYYRENKE
MHVISKEPFEEAAKRYPNDSLAIRALYRLVRETDFSSPAEMLTLIPSLDNFKYRNKWWVLDVGGNNLRVIAYINFVNKRF
YVKHIATHADYDKLTRYYRENKE
Download Length: 312 bp
>T232605 NZ_CP127408:c281175-280882 [Stenotrophomonas sp. 59]
ATGAGCAAGCTGAAGACGATTCCCTTCGATCCCGCCGACTATCTGGCTGATGACGTCGCAATCGCCGCCTATCTGAGCGA
GGCGTTGGCAGCAGGTGATGCGGGCCACTTCCAGGAGGCGCTCGGAACAGTGGCGCGCGCCCGCGGCATGGGCGGCGTTG
CCGAGGTCTCCGGTCTTGGACGCGAGAGCCTGTACAAGGCGCTGCGCCCCGGAGCACACCCACGCTTCGATACCGTGCAA
CGTGTGCTGTCGGCGCTTGGGGTGCACCTGATCGTGCAGGCCGGCAAGGCCTGA
ATGAGCAAGCTGAAGACGATTCCCTTCGATCCCGCCGACTATCTGGCTGATGACGTCGCAATCGCCGCCTATCTGAGCGA
GGCGTTGGCAGCAGGTGATGCGGGCCACTTCCAGGAGGCGCTCGGAACAGTGGCGCGCGCCCGCGGCATGGGCGGCGTTG
CCGAGGTCTCCGGTCTTGGACGCGAGAGCCTGTACAAGGCGCTGCGCCCCGGAGCACACCCACGCTTCGATACCGTGCAA
CGTGTGCTGTCGGCGCTTGGGGTGCACCTGATCGTGCAGGCCGGCAAGGCCTGA
Antitoxin
Download Length: 140 a.a. Molecular weight: 15377.46 Da Isoelectric Point: 4.4420
>AT232605 WP_011251286.1 NZ_CP091062:c57838-57419 [Klebsiella pneumoniae]
MITDTAKAIEATKQLVAAVPFLGGSSSESDYREAMELVDYLIENDDENPLIDFLASKIADYEDNSPRFAEFNKAIAEIPV
GVALLRTLIDQHKLSYSDLKDEIGSKSLVSQILSGQRSLTITHIKALSARFGVKPEWFL
MITDTAKAIEATKQLVAAVPFLGGSSSESDYREAMELVDYLIENDDENPLIDFLASKIADYEDNSPRFAEFNKAIAEIPV
GVALLRTLIDQHKLSYSDLKDEIGSKSLVSQILSGQRSLTITHIKALSARFGVKPEWFL
Download Length: 420 bp
>AT232605 NZ_CP127408:c281504-281214 [Stenotrophomonas sp. 59]
ATGGCGATTCTCCAGGCAACAGAAACATTCACGCGATGGCTGCGCGGACTCAACGACAGCAGGGCCCGCGGCGTGATCGT
GGAGCGCCTGCAGCGCGTCGCCCGCGGTCTCGAGGGAGATGTTCGATCAGTGGGTCATGGCGTGAGCGAACTGCGAATCA
ACCATGGGCCGGGATATCGCGTGTATTTCACGCGTCGCGGGAGATCCATCGTCGTGCTCCTGCACGGTGGCGACAAGTCG
AGCCAGCGTCGCGATATCGAAAAAGCGGTCAGGCTCGCGGAGCTGCTGTAG
ATGGCGATTCTCCAGGCAACAGAAACATTCACGCGATGGCTGCGCGGACTCAACGACAGCAGGGCCCGCGGCGTGATCGT
GGAGCGCCTGCAGCGCGTCGCCCGCGGTCTCGAGGGAGATGTTCGATCAGTGGGTCATGGCGTGAGCGAACTGCGAATCA
ACCATGGGCCGGGATATCGCGTGTATTTCACGCGTCGCGGGAGATCCATCGTCGTGCTCCTGCACGGTGGCGACAAGTCG
AGCCAGCGTCGCGATATCGAAAAAGCGGTCAGGCTCGCGGAGCTGCTGTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|