Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | yefM-yoeB (relBE)/YoeB-YefM |
Location | 1907246..1907748 | Replicon | chromosome |
Accession | NZ_CP091044 | ||
Organism | Escherichia coli strain STEC346 |
Toxin (Protein)
Gene name | yoeB | Uniprot ID | U9YDH0 |
Locus tag | L1P11_RS09285 | Protein ID | WP_000767829.1 |
Coordinates | 1907494..1907748 (+) | Length | 85 a.a. |
Antitoxin (Protein)
Gene name | yefM | Uniprot ID | S1Q063 |
Locus tag | L1P11_RS09280 | Protein ID | WP_001259255.1 |
Coordinates | 1907246..1907497 (+) | Length | 84 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
L1P11_RS09255 (1902424) | 1902424..1903491 | - | 1068 | WP_000080090.1 | bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB | - |
L1P11_RS09260 (1903491) | 1903491..1904561 | - | 1071 | WP_000108941.1 | histidinol-phosphate transaminase | - |
L1P11_RS09265 (1904558) | 1904558..1905862 | - | 1305 | WP_001367667.1 | histidinol dehydrogenase | - |
L1P11_RS09270 (1905868) | 1905868..1906767 | - | 900 | WP_000131792.1 | ATP phosphoribosyltransferase | - |
L1P11_RS09275 (1906913) | 1906913..1906963 | - | 51 | WP_001364200.1 | his operon leader peptide | - |
L1P11_RS09280 (1907246) | 1907246..1907497 | + | 252 | WP_001259255.1 | YoeB-YefM toxin-antitoxin system antitoxin YefM | Antitoxin |
L1P11_RS09285 (1907494) | 1907494..1907748 | + | 255 | WP_000767829.1 | type II toxin-antitoxin system mRNA interferase toxin YoeB | Toxin |
L1P11_RS09290 (1907831) | 1907831..1908655 | + | 825 | WP_000754737.1 | SDR family oxidoreductase | - |
L1P11_RS09295 (1908701) | 1908701..1909630 | + | 930 | WP_000803351.1 | LysR substrate-binding domain-containing protein | - |
L1P11_RS09300 (1909845) | 1909845..1909907 | + | 63 | WP_010723108.1 | membrane protein YoeI | - |
L1P11_RS09305 (1909897) | 1909897..1911255 | + | 1359 | WP_000019197.1 | putrescine/proton symporter PlaP | - |
L1P11_RS09310 (1911434) | 1911434..1912492 | + | 1059 | WP_000492333.1 | thiosulfate utilization transporter TsuA/YeeE | - |
L1P11_RS09315 (1912506) | 1912506..1912733 | + | 228 | WP_000985273.1 | thiosulfate utilization sulfurtransferase TsuB/YeeD | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 85 a.a. Molecular weight: 10183.58 Da Isoelectric Point: 8.0353
>T232519 WP_000767829.1 NZ_CP091044:1907494-1907748 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY
Download Length: 255 bp
>T232519 NZ_CP127314:4677710-4677862 [Escherichia coli]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9307.58 Da Isoelectric Point: 4.7954
>AT232519 WP_001259255.1 NZ_CP091044:1907246-1907497 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE
Download Length: 252 bp
>AT232519 NZ_CP127314:c4677661-4677604 [Escherichia coli]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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