Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 806234..806927 Replicon chromosome
Accession NZ_CP091044
Organism Escherichia coli strain STEC346

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag L1P11_RS04020 Protein ID WP_000415584.1
Coordinates 806234..806530 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag L1P11_RS04025 Protein ID WP_000650107.1
Coordinates 806532..806927 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L1P11_RS03990 (801909) 801909..802223 - 315 WP_000958598.1 putative quinol monooxygenase -
L1P11_RS03995 (802254) 802254..802835 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
L1P11_RS04000 (802945) 802945..804294 - 1350 WP_000673406.1 quorum sensing histidine kinase QseC -
L1P11_RS04005 (804291) 804291..804950 - 660 WP_001221491.1 quorum sensing response regulator transcription factor QseB -
L1P11_RS04010 (805102) 805102..805494 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
L1P11_RS04015 (805547) 805547..806029 + 483 WP_000183494.1 GyrI-like domain-containing protein -
L1P11_RS04020 (806234) 806234..806530 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
L1P11_RS04025 (806532) 806532..806927 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
L1P11_RS04030 (807060) 807060..808667 + 1608 WP_001324265.1 ABC transporter substrate-binding protein -
L1P11_RS04035 (808805) 808805..811063 + 2259 WP_001281881.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 794507..806927 12420


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T232514 WP_000415584.1 NZ_CP091044:806234-806530 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T232514 NZ_CP127314:3273641-3273748 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCGTGATTTTCTGGCACGACCTGGCAGCACCGATCCTTGCGGGAATTATTACCGCAGCGAT
TGTTGGCTGGTGGCGTAGCCGGAAGTAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT232514 WP_000650107.1 NZ_CP091044:806532-806927 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT232514 NZ_CP127314:c3273585-3273524 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTGACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References