Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yefM-yoeB (relBE)/YoeB-YefM |
| Location | 1891410..1891912 | Replicon | chromosome |
| Accession | NZ_CP091029 | ||
| Organism | Escherichia coli strain STEC384 | ||
Toxin (Protein)
| Gene name | yoeB | Uniprot ID | U9YDH0 |
| Locus tag | L1P14_RS09220 | Protein ID | WP_000767829.1 |
| Coordinates | 1891658..1891912 (+) | Length | 85 a.a. |
Antitoxin (Protein)
| Gene name | yefM | Uniprot ID | S1Q063 |
| Locus tag | L1P14_RS09215 | Protein ID | WP_001259255.1 |
| Coordinates | 1891410..1891661 (+) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| L1P14_RS09190 (1886588) | 1886588..1887655 | - | 1068 | WP_000080060.1 | bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB | - |
| L1P14_RS09195 (1887655) | 1887655..1888725 | - | 1071 | WP_000108941.1 | histidinol-phosphate transaminase | - |
| L1P14_RS09200 (1888722) | 1888722..1890026 | - | 1305 | WP_001317939.1 | histidinol dehydrogenase | - |
| L1P14_RS09205 (1890032) | 1890032..1890931 | - | 900 | WP_000131782.1 | ATP phosphoribosyltransferase | - |
| L1P14_RS09210 (1891077) | 1891077..1891127 | - | 51 | WP_001364200.1 | his operon leader peptide | - |
| L1P14_RS09215 (1891410) | 1891410..1891661 | + | 252 | WP_001259255.1 | YoeB-YefM toxin-antitoxin system antitoxin YefM | Antitoxin |
| L1P14_RS09220 (1891658) | 1891658..1891912 | + | 255 | WP_000767829.1 | type II toxin-antitoxin system mRNA interferase toxin YoeB | Toxin |
| L1P14_RS09225 (1891995) | 1891995..1892819 | + | 825 | WP_000754763.1 | SDR family oxidoreductase | - |
| L1P14_RS09230 (1892865) | 1892865..1893794 | + | 930 | WP_000803351.1 | LysR substrate-binding domain-containing protein | - |
| L1P14_RS09235 (1894009) | 1894009..1894071 | + | 63 | WP_010723108.1 | membrane protein YoeI | - |
| L1P14_RS09240 (1894061) | 1894061..1895419 | + | 1359 | WP_000019197.1 | putrescine/proton symporter PlaP | - |
| L1P14_RS09245 (1895598) | 1895598..1896656 | + | 1059 | WP_000492335.1 | thiosulfate utilization transporter TsuA/YeeE | - |
| L1P14_RS09250 (1896670) | 1896670..1896897 | + | 228 | WP_000985273.1 | thiosulfate utilization sulfurtransferase TsuB/YeeD | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 85 a.a. Molecular weight: 10183.58 Da Isoelectric Point: 8.0353
>T232485 WP_000767829.1 NZ_CP091029:1891658-1891912 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY
Download Length: 255 bp
>T232485 NZ_CP127306:2449948-2450271 [Escherichia coli]
ATGAAATTTCTACCTGCAACAAATATGCGGGCGGCGAAGCCATGCCTGCCGCCCGTGACTATCTGGCAAATGCTACTTAG
TCGTCTGCTGGAACAGCATTATGGCCTGTCGCTAAACGATACGCCTTTCTGTGATGCAACCGTCATACAGGAACACATCG
ATGCCGGTATCACTCTCGCTAATGCCATTAACTTTCTAGTGGAAAAGTACGAACTGGTTCGTATCGATCGCAGAGGGTTT
AGCTGGCAAGAACAAACGCCATATCTCACGATTATTGATATCATGAGAGCCCGTCGCGATCTGGGTATAATGAATCGTAA
TTAG
ATGAAATTTCTACCTGCAACAAATATGCGGGCGGCGAAGCCATGCCTGCCGCCCGTGACTATCTGGCAAATGCTACTTAG
TCGTCTGCTGGAACAGCATTATGGCCTGTCGCTAAACGATACGCCTTTCTGTGATGCAACCGTCATACAGGAACACATCG
ATGCCGGTATCACTCTCGCTAATGCCATTAACTTTCTAGTGGAAAAGTACGAACTGGTTCGTATCGATCGCAGAGGGTTT
AGCTGGCAAGAACAAACGCCATATCTCACGATTATTGATATCATGAGAGCCCGTCGCGATCTGGGTATAATGAATCGTAA
TTAG
Antitoxin
Download Length: 84 a.a. Molecular weight: 9307.58 Da Isoelectric Point: 4.7954
>AT232485 WP_001259255.1 NZ_CP091029:1891410-1891661 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE
Download Length: 252 bp
>AT232485 NZ_CP127306:2449571-2449927 [Escherichia coli]
ATGAACAATCACTCAGAATCCGGTGCCATACCGGAGAATCTCCCCTGCAAACAGTGGGGGCTAAAGAGTACGATCACACC
CTGTTTTGGAGCTCGGCTGGTGCAAGAAGGCTACCGCCTGCATTTTCTCGCTGACCGCGCCGGGTTTAACGGTTCTTTCA
GCGACGAGCATGTGTTGCGCCTCGACCAGGCCTTTCCGTTGATACTCAAGCAGCTGGAGCTGTTGCTCACCAGCGGAGAA
CTCTCTCCCCGCCATCAGCACTGTATCACCCTCTATCACAACGGACTCACCTGCGAAGCCGATACACTTGGTAGTTGTGG
CTACGTATACATCGCCATTTATCCCACTCAACGTTAA
ATGAACAATCACTCAGAATCCGGTGCCATACCGGAGAATCTCCCCTGCAAACAGTGGGGGCTAAAGAGTACGATCACACC
CTGTTTTGGAGCTCGGCTGGTGCAAGAAGGCTACCGCCTGCATTTTCTCGCTGACCGCGCCGGGTTTAACGGTTCTTTCA
GCGACGAGCATGTGTTGCGCCTCGACCAGGCCTTTCCGTTGATACTCAAGCAGCTGGAGCTGTTGCTCACCAGCGGAGAA
CTCTCTCCCCGCCATCAGCACTGTATCACCCTCTATCACAACGGACTCACCTGCGAAGCCGATACACTTGGTAGTTGTGG
CTACGTATACATCGCCATTTATCCCACTCAACGTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|