Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | hok-sok/- |
| Location | 88249..88503 | Replicon | plasmid p1_STEC383 |
| Accession | NZ_CP091027 | ||
| Organism | Escherichia coli strain STEC383 | ||
Toxin (Protein)
| Gene name | srnB | Uniprot ID | G9G1E3 |
| Locus tag | L1P12_RS25695 | Protein ID | WP_001312851.1 |
| Coordinates | 88249..88398 (-) | Length | 50 a.a. |
Antitoxin (RNA)
| Gene name | srnC | ||
| Locus tag | - | ||
| Coordinates | 88442..88503 (+) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| L1P12_RS25650 (83963) | 83963..84364 | - | 402 | Protein_104 | IS21 family transposase | - |
| L1P12_RS25655 (84452) | 84452..84571 | - | 120 | Protein_105 | 3'-5' exonuclease | - |
| L1P12_RS25660 (84617) | 84617..84895 | - | 279 | WP_248699117.1 | type II toxin-antitoxin system toxin YacB | - |
| L1P12_RS25665 (84895) | 84895..85164 | - | 270 | WP_000079941.1 | type II toxin-antitoxin system antitoxin YacA | - |
| L1P12_RS25670 (86077) | 86077..86934 | - | 858 | WP_136769174.1 | incFII family plasmid replication initiator RepA | - |
| L1P12_RS25675 (86927) | 86927..87409 | - | 483 | WP_001523473.1 | hypothetical protein | - |
| L1P12_RS25680 (87402) | 87402..87449 | - | 48 | WP_229471593.1 | hypothetical protein | - |
| L1P12_RS25685 (87440) | 87440..87691 | + | 252 | WP_223195197.1 | replication protein RepA | - |
| L1P12_RS25690 (87708) | 87708..87965 | - | 258 | WP_000083845.1 | replication regulatory protein RepA | - |
| L1P12_RS25695 (88249) | 88249..88398 | - | 150 | WP_001312851.1 | Hok/Gef family protein | Toxin |
| - (88442) | 88442..88503 | + | 62 | NuclAT_1 | - | Antitoxin |
| - (88442) | 88442..88503 | + | 62 | NuclAT_1 | - | Antitoxin |
| - (88442) | 88442..88503 | + | 62 | NuclAT_1 | - | Antitoxin |
| - (88442) | 88442..88503 | + | 62 | NuclAT_1 | - | Antitoxin |
| L1P12_RS25700 (88759) | 88759..88833 | - | 75 | Protein_114 | endonuclease | - |
| L1P12_RS25705 (89024) | 89024..89221 | - | 198 | WP_097464675.1 | hypothetical protein | - |
| L1P12_RS25710 (89357) | 89357..89917 | - | 561 | WP_001587438.1 | fertility inhibition protein FinO | - |
| L1P12_RS25715 (89972) | 89972..90718 | - | 747 | WP_136769175.1 | conjugal transfer pilus acetylase TraX | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | sul1 / qacE / ant(3'')-Ia / dfrA1 / tet(A) / sul3 | - | 1..111805 | 111805 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 50 a.a. Molecular weight: 5542.67 Da Isoelectric Point: 8.7678
>T232472 WP_001312851.1 NZ_CP091027:c88398-88249 [Escherichia coli]
MTKYALIGLLAVCATVLCFSLIFRERLCELNIHRGNTVVQVTLAYEARK
MTKYALIGLLAVCATVLCFSLIFRERLCELNIHRGNTVVQVTLAYEARK
Download Length: 150 bp
>T232472 NZ_CP127303:4826274-4826492 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTATACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTATACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA
Antitoxin
Download Length: 62 bp
>AT232472 NZ_CP091027:88442-88503 [Escherichia coli]
TTAAGGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT
TTAAGGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
