Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 784731..785424 Replicon chromosome
Accession NZ_CP091026
Organism Escherichia coli strain STEC383

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag L1P12_RS03800 Protein ID WP_000415584.1
Coordinates 784731..785027 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag L1P12_RS03805 Protein ID WP_000650107.1
Coordinates 785029..785424 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L1P12_RS03765 (779819) 779819..780133 - 315 WP_000958598.1 putative quinol monooxygenase -
L1P12_RS03770 (780164) 780164..780745 - 582 WP_235387432.1 NADPH:quinone oxidoreductase MdaB -
L1P12_RS03775 (781064) 781064..781396 + 333 WP_000917684.1 DUF2645 family protein -
L1P12_RS03780 (781442) 781442..782791 - 1350 WP_096111143.1 quorum sensing histidine kinase QseC -
L1P12_RS03785 (782788) 782788..783447 - 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
L1P12_RS03790 (783599) 783599..783991 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
L1P12_RS03795 (784044) 784044..784526 + 483 WP_000183505.1 GyrI-like domain-containing protein -
L1P12_RS03800 (784731) 784731..785027 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
L1P12_RS03805 (785029) 785029..785424 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
L1P12_RS03810 (785557) 785557..787164 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
L1P12_RS03815 (787302) 787302..789560 + 2259 WP_001281881.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T232446 WP_000415584.1 NZ_CP091026:784731-785027 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T232446 NZ_CP127300:48953-49234 [Escherichia coli]
TTGATTAAGTCATTTCGCCATAAAGGGCTTGAACGCTTTTTCAAGACAGGTTCAACCGCAGGCATTCAGGCCAAACATGC
GGTTAAGCTACGCATTCAATTGACTGCTCTTAATACAGCTAAACGCCCGGACGATATGTCTGCGCCTGGATGGGAATTGC
ACCCTCTAAAGGGGGCGGACCTTAAAGGTCACTGGGCAATATCGGTAAACGGTAACTGGCGACTTACCTTCCGATTTGAA
GGAGAAGACGCAATTCTAGTTGACTATCAGGATTATCATTGA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT232446 WP_000650107.1 NZ_CP091026:785029-785424 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT232446 NZ_CP127300:49243-49524 [Escherichia coli]
ATGAGTCGTATGCATAATCCCGCGCATCCTGGCGCGGTTCTTCGTGAATATTTGGGAGACATGTCAGTCACAGACGCCGC
TGCTGCATTAGGCATTACTCGCACGGCACTTTCCCGAATTCTGAACGAAAAAGCAGGCATTTCTGCTGATATGGCACTTC
GTCTGGAGTCCGCTCTTGGAACCAGTGCCGAAATGTGGACCGGTATGCAATCTCAGTATGAGCTTTGGGTTGCTTCGCAA
ACCGCTCGCCCAAACATCCGTCCATTATTTTTCCACGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References