Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4836099..4836701 Replicon chromosome
Accession NZ_CP091024
Organism Escherichia coli strain STEC379

Toxin (Protein)


Gene name higB Uniprot ID U9XIS6
Locus tag L1P13_RS23720 Protein ID WP_000897305.1
Coordinates 4836390..4836701 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag L1P13_RS23715 Protein ID WP_000356397.1
Coordinates 4836099..4836389 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L1P13_RS23690 (4832025) 4832025..4832927 + 903 WP_000331377.1 formate dehydrogenase O subunit beta -
L1P13_RS23695 (4832924) 4832924..4833559 + 636 WP_000829013.1 formate dehydrogenase cytochrome b556 subunit -
L1P13_RS23700 (4833556) 4833556..4834485 + 930 WP_000027708.1 formate dehydrogenase accessory protein FdhE -
L1P13_RS23705 (4834815) 4834815..4835057 - 243 WP_001086388.1 protein YiiF -
L1P13_RS23710 (4835276) 4835276..4835494 - 219 WP_001295676.1 CopG family transcriptional regulator -
L1P13_RS23715 (4836099) 4836099..4836389 - 291 WP_000356397.1 NadS family protein Antitoxin
L1P13_RS23720 (4836390) 4836390..4836701 - 312 WP_000897305.1 hypothetical protein Toxin
L1P13_RS23725 (4836930) 4836930..4837838 + 909 WP_001162704.1 alpha/beta hydrolase -
L1P13_RS23730 (4837902) 4837902..4838843 - 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
L1P13_RS23735 (4838888) 4838888..4839325 - 438 WP_000560983.1 D-aminoacyl-tRNA deacylase -
L1P13_RS23740 (4839322) 4839322..4840194 - 873 WP_000920762.1 virulence factor BrkB family protein -
L1P13_RS23745 (4840188) 4840188..4840787 - 600 WP_001295269.1 glucose-1-phosphatase -
L1P13_RS23750 (4840886) 4840886..4841671 - 786 WP_000059678.1 DeoR/GlpR family DNA-binding transcription regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12190.19 Da        Isoelectric Point: 9.7791

>T232439 WP_000897305.1 NZ_CP091024:c4836701-4836390 [Escherichia coli]
MLFIETEIFTEDVQKLLTDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

>T232439 NZ_CP127297:3144612-3144719 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT232439 WP_000356397.1 NZ_CP091024:c4836389-4836099 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp

>AT232439 NZ_CP127297:c3144562-3144499 [Escherichia coli]
TCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTAAACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y7I7

Antitoxin

Source ID Structure

References