Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yafN-yafO (relBE)/YafO-YafN |
| Location | 3788863..3789557 | Replicon | chromosome |
| Accession | NZ_CP091022 | ||
| Organism | Escherichia coli strain STEC276 | ||
Toxin (Protein)
| Gene name | yafO | Uniprot ID | S1EXB8 |
| Locus tag | L1O93_RS18520 | Protein ID | WP_001263493.1 |
| Coordinates | 3788863..3789261 (-) | Length | 133 a.a. |
Antitoxin (Protein)
| Gene name | yafN | Uniprot ID | S1FJN6 |
| Locus tag | L1O93_RS18525 | Protein ID | WP_000554757.1 |
| Coordinates | 3789264..3789557 (-) | Length | 98 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| - (3784523) | 3784523..3784603 | - | 81 | NuclAT_13 | - | - |
| - (3784523) | 3784523..3784603 | - | 81 | NuclAT_13 | - | - |
| - (3784523) | 3784523..3784603 | - | 81 | NuclAT_13 | - | - |
| - (3784523) | 3784523..3784603 | - | 81 | NuclAT_13 | - | - |
| L1O93_RS18490 (3783863) | 3783863..3785107 | - | 1245 | WP_240992375.1 | esterase FrsA | - |
| L1O93_RS18495 (3785199) | 3785199..3785657 | - | 459 | WP_001291990.1 | xanthine phosphoribosyltransferase | - |
| L1O93_RS18500 (3785918) | 3785918..3787375 | + | 1458 | WP_001293009.1 | cytosol nonspecific dipeptidase | - |
| L1O93_RS18505 (3787432) | 3787432..3787953 | - | 522 | Protein_3639 | peptide chain release factor H | - |
| L1O93_RS18510 (3787952) | 3787952..3788155 | - | 204 | Protein_3640 | RtcB family protein | - |
| L1O93_RS18515 (3788401) | 3788401..3788853 | - | 453 | WP_001059847.1 | GNAT family N-acetyltransferase | - |
| L1O93_RS18520 (3788863) | 3788863..3789261 | - | 399 | WP_001263493.1 | type II toxin-antitoxin system mRNA interferase toxin YafO | Toxin |
| L1O93_RS18525 (3789264) | 3789264..3789557 | - | 294 | WP_000554757.1 | type I toxin-antitoxin system antitoxin YafN | Antitoxin |
| L1O93_RS18530 (3789609) | 3789609..3790664 | - | 1056 | WP_001226164.1 | DNA polymerase IV | - |
| L1O93_RS18535 (3790735) | 3790735..3791658 | - | 924 | WP_001232547.1 | putative lateral flagellar export/assembly protein LafU | - |
| L1O93_RS18540 (3791661) | 3791661..3792524 | - | 864 | WP_001169518.1 | flagellar motor stator protein MotA | - |
| L1O93_RS18545 (3792537) | 3792537..3793253 | - | 717 | WP_000938723.1 | FliA/WhiG family RNA polymerase sigma factor | - |
| L1O93_RS18550 (3793273) | 3793273..3793740 | - | 468 | WP_000725257.1 | flagellar basal body-associated FliL family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 3757260..3790664 | 33404 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 133 a.a. Molecular weight: 15472.83 Da Isoelectric Point: 8.0949
>T232407 WP_001263493.1 NZ_CP091022:c3789261-3788863 [Escherichia coli]
MRVFKTKLIRLQLTAEELDALTADFISYKRDGVLPDIFGRDALYDDSFTWPLIKFERVAHIHLANVNNPFPPQLRQFSRT
NDEAHLVYCQGAFDEQAWLLIAILKPEPHKQARDNNQMHKIGKMAEAFRMRF
MRVFKTKLIRLQLTAEELDALTADFISYKRDGVLPDIFGRDALYDDSFTWPLIKFERVAHIHLANVNNPFPPQLRQFSRT
NDEAHLVYCQGAFDEQAWLLIAILKPEPHKQARDNNQMHKIGKMAEAFRMRF
Download Length: 399 bp
>T232407 NZ_CP127277:2850918-2851295 [Mycobacterium tuberculosis]
GTGAAGCTGATCGACACCACCATCGCGGTCGACCACCTTCGCGGCGAACCCGCGGCAGCCGTGCTGCTCGCCGAACTGAT
AAACAACGGTGAGGAGATCGCGGCCAGCGAGCTGGTCCGATTCGAACTCCTCGCCGGTGTGCGGGAAAGCGAACTCGCGG
CGCTCGAGGCCTTCTTCTCGGCAGTGGTGTGGACCCTGGTGACCGAGGACATTGCCCGGATCGGCGGACGACTCGCCCGT
CGATACCGGTCCAGCCACCGCGGTATCGACGACGTGGACTACCTGATCGCTGCGACCGCCATTGTGGTCGACGCCGACCT
GCTCACCACCAATGTGCGCCACTTCCCGATGTTCCCGGATCTGCAGCCGCCGTACTGA
GTGAAGCTGATCGACACCACCATCGCGGTCGACCACCTTCGCGGCGAACCCGCGGCAGCCGTGCTGCTCGCCGAACTGAT
AAACAACGGTGAGGAGATCGCGGCCAGCGAGCTGGTCCGATTCGAACTCCTCGCCGGTGTGCGGGAAAGCGAACTCGCGG
CGCTCGAGGCCTTCTTCTCGGCAGTGGTGTGGACCCTGGTGACCGAGGACATTGCCCGGATCGGCGGACGACTCGCCCGT
CGATACCGGTCCAGCCACCGCGGTATCGACGACGTGGACTACCTGATCGCTGCGACCGCCATTGTGGTCGACGCCGACCT
GCTCACCACCAATGTGCGCCACTTCCCGATGTTCCCGGATCTGCAGCCGCCGTACTGA
Antitoxin
Download Length: 98 a.a. Molecular weight: 11233.81 Da Isoelectric Point: 5.9050
>AT232407 WP_000554757.1 NZ_CP091022:c3789557-3789264 [Escherichia coli]
MHRILAEKSVNITELRKNPAKYFIDQPVAVLSNNRPAGYLLSASAFEALMDMLAEQEEKKPIKARFRPSAARLEEITRRA
EKYLNDMTDDDFNDFKE
MHRILAEKSVNITELRKNPAKYFIDQPVAVLSNNRPAGYLLSASAFEALMDMLAEQEEKKPIKARFRPSAARLEEITRRA
EKYLNDMTDDDFNDFKE
Download Length: 294 bp
>AT232407 NZ_CP127277:2850664-2850921 [Mycobacterium tuberculosis]
ATGCGGACTCAGGTGACCCTGGGCAAAGAGGAGCTTGAGCTGCTCGATCGTGCCGCCAAGGCGAGTGGCGCATCGCGGTC
CGAACTCATCCGACGCGCAATTCACCGTGCCTACGGGACTGGATCCAAGCAGGAACGGCTCGCCGCGCTCGACCACAGCC
GTGGCTCGTGGCGAGGACGGGACTTCACCGGCACCGAGTATGTCGACGCCATTCGGGGCGACCTCAACGAACGACTTGCT
CGGCTCGGTCTGGCGTGA
ATGCGGACTCAGGTGACCCTGGGCAAAGAGGAGCTTGAGCTGCTCGATCGTGCCGCCAAGGCGAGTGGCGCATCGCGGTC
CGAACTCATCCGACGCGCAATTCACCGTGCCTACGGGACTGGATCCAAGCAGGAACGGCTCGCCGCGCTCGACCACAGCC
GTGGCTCGTGGCGAGGACGGGACTTCACCGGCACCGAGTATGTCGACGCCATTCGGGGCGACCTCAACGAACGACTTGCT
CGGCTCGGTCTGGCGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|