Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 481703..482358 Replicon chromosome
Accession NC_011527
Organism Coxiella burnetii CbuG Q212

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag CBUG_RS02585 Protein ID WP_011996617.1
Coordinates 481703..482041 (+) Length 113 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag CBUG_RS02590 Protein ID WP_010958263.1
Coordinates 482047..482358 (+) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CBUG_RS02570 477427..478182 + 756 WP_012569800.1 pyridoxine 5'-phosphate synthase -
CBUG_RS02575 478358..480023 - 1666 Protein_509 CBU_1493 family Dot/Icm T4SS effector -
CBUG_RS02580 480199..481344 - 1146 WP_012569768.1 ISAs1-like element ISCbu1 family transposase -
CBUG_RS02585 481703..482041 + 339 WP_011996617.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CBUG_RS02590 482047..482358 + 312 WP_010958263.1 HigA family addiction module antidote protein Antitoxin
CBUG_RS02595 482428..483159 - 732 WP_012569802.1 UDP-2,3-diacylglucosamine diphosphatase -
CBUG_RS02600 483316..484713 + 1398 WP_012569803.1 glutamate--tRNA ligase -
CBUG_RS02605 484704..486086 + 1383 WP_010958260.1 cysteine--tRNA ligase -
CBUG_RS02615 486406..487083 + 678 WP_012569804.1 cyclin protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 480199..481344 1145


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(20-112)

Antitoxin

Cro/C1-type helix-turn-helix domain

(26-72)


Sequences

Toxin        


Download         Length: 113 a.a.        Molecular weight: 13428.63 Da        Isoelectric Point: 10.2262

>T23231 WP_011996617.1 NC_011527:481703-482041 [Coxiella burnetii CbuG_Q212]
MPLTLYIMLDVTRKTVILEVMIKSFKDKYTKYLYEGVSVSKWQAIRKQAERRLQILDSVTSLDDLRSLPSNRFESLRGNR
KGQFSIRINKQWRICFKWINNEPTEVEIVDYH

Download         Length: 339 bp

>T23231 NC_011527:481703-482041 [Coxiella burnetii CbuG_Q212]
TTGCCTCTTACGCTGTATATTATGCTTGATGTAACGCGTAAAACTGTTATCCTTGAAGTGATGATAAAAAGTTTCAAGGA
CAAATACACTAAATATTTATATGAAGGTGTATCCGTTTCAAAATGGCAAGCCATACGAAAGCAGGCGGAAAGACGGCTTC
AGATTTTGGATTCAGTGACATCGTTAGATGATTTGAGAAGTTTGCCAAGCAATCGTTTTGAATCGTTGCGGGGGAATAGA
AAAGGACAATTTAGTATAAGGATTAATAAGCAATGGCGCATTTGTTTTAAGTGGATTAACAATGAGCCAACTGAAGTTGA
AATTGTGGATTATCATTAG

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11458.39 Da        Isoelectric Point: 10.1699

>AT23231 WP_010958263.1 NC_011527:482047-482358 [Coxiella burnetii CbuG_Q212]
MKMAANRMRPIHPGEILAEELGFLDKMSANQLAKHLAIPTNRVTAILNGARSITADTALRLAKFFGTTPEFWLNLQDAYD
IKMALKKSGKKIEKEVTPYDQAA

Download         Length: 312 bp

>AT23231 NC_011527:482047-482358 [Coxiella burnetii CbuG_Q212]
ATGAAAATGGCAGCTAATAGAATGCGACCCATACATCCAGGTGAGATCCTTGCTGAAGAGTTGGGGTTTTTAGATAAGAT
GTCAGCTAATCAGTTAGCTAAACATTTAGCAATTCCGACCAACCGAGTGACCGCCATTCTCAATGGCGCGCGATCCATTA
CGGCGGATACCGCGCTACGATTGGCTAAGTTTTTTGGGACGACGCCGGAATTTTGGCTAAATCTCCAAGACGCCTATGAC
ATAAAAATGGCATTGAAAAAGTCCGGCAAAAAAATCGAAAAAGAAGTAACCCCTTACGACCAAGCCGCCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References