Detailed information of TA system TA232288

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 9158..9681
• Replicon: plasmid pSEBC1191-1
• Accession: NZ_CP090999
• Organism: Staphylococcus epidermidis strain BC1191

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: KB233_RS11305
• Protein ID: WP_002456264.1
• Coordinates: 9415..9681 (+)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: C5QR06
• Locus tag: KB233_RS11300
• Protein ID: WP_002441972.1
• Coordinates: 9158..9415 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KB233_RS11275 (KB233_11275)	5398..6219	-	822	WP_161382396.1	relaxase MobL	-
KB233_RS11280 (KB233_11280)	6231..6614	-	384	WP_002456270.1	hypothetical protein	-
KB233_RS11285 (KB233_11285)	6616..6894	-	279	WP_002456269.1	hypothetical protein	-
KB233_RS11290 (KB233_11290)	8385..8564	+	180	WP_002456267.1	CsbD family protein	-
KB233_RS11295 (KB233_11295)	8597..8995	-	399	WP_002498728.1	YolD-like family protein	-
KB233_RS11300 (KB233_11300)	9158..9415	+	258	WP_002441972.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
KB233_RS11305 (KB233_11305)	9415..9681	+	267	WP_002456264.1	Txe/YoeB family addiction module toxin	Toxin
KB233_RS11310 (KB233_11310)	9698..9868	+	171	WP_002456263.1	hypothetical protein	-
KB233_RS11315 (KB233_11315)	10229..10453	+	225	WP_225981062.1	hypothetical protein	-
KB233_RS11320 (KB233_11320)	10954..11310	-	357	WP_002441965.1	hypothetical protein	-
KB233_RS11325 (KB233_11325)	11444..11527	+	84	Protein_15	Replication protein RepB	-
KB233_RS11330 (KB233_11330)	11714..12652	-	939	WP_161382398.1	replication initiator protein A	-
KB233_RS11335 (KB233_11335)	13085..13855	+	771	WP_142640514.1	DUF536 domain-containing protein	-
KB233_RS11340 (KB233_11340)	13978..14400	-	423	WP_002499214.1	VOC family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Mobilizable plasmid	-	-	1..39644	39644

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (4-87)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-67)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10722.36 Da
• Isoelectric Point: 10.2282

>T232288 WP_002456264.1 NZ_CP090999:9415-9681 [Staphylococcus epidermidis]
MAKYKINIKNSAKTDLKKIKRSHLQEQFLKIVEILKYDPYQQSQSFEKLHPKHLGRYSRRINHQHRVVYTIDEENKEVLI
LATWSHYE

Nucleotide

• Length: 267 bp

>T232288 NZ_CP127275:2847263-2847676 [Mycobacterium tuberculosis]
ATGGTGTTCTGCGTCGACACCAGCGCGTGGCATCACGCGGCGCGGCCGGAAGTTGCGCGCCGATGGTTGGCGGCCTTGTC
CGCGGACCAGATCGGCATCTGCGACCACGTGCGGTTGGAGATCCTGTACTCGGCGAACTCCGCTACCGACTACGACGCGC
TCGCCGACGAACTCGACGGCTTGGCCCGTATACCAGTCGGTGCCGAAACCTTTACGCGCGCATGCCAAGTCCAGCGTGAG
CTTGCCCACGTCGCCGGTCTGCATCACCGCAGCGTGAAGATCGCCGATCTTGTCATCGCCGCGGCGGCCGAACTTTCAGG
CACCATCGTGTGGCATTACGACGAGAACTATGACCGGGTCGCCGCCATCACCGGCCAACCTACGGAGTGGATCGTGCCGC
GCGGGACCCTTTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 10041.10 Da
• Isoelectric Point: 4.5610

>AT232288 WP_002441972.1 NZ_CP090999:9158-9415 [Staphylococcus epidermidis]
MKSKTPTEARKDFYQLLKRVNNDHEPVYIEGKYDESNAVIIGMEDWRSINETIYLEATGTMDKVREREHDNSGYTNIDDI
DWARL

Nucleotide

• Length: 258 bp

>AT232288 NZ_CP127275:2847715-2847972 [Mycobacterium tuberculosis]
ATGCGGACTCAGGTGACCCTGGGCAAAGAGGAGCTTGAGCTGCTCGATCGTGCCGCCAAGGCGAGTGGCGCATCGCGGTC
CGAACTCATCCGACGCGCAATTCACCGTGCCTACGGGACTGGATCCAAGCAGGAACGGCTCGCCGCGCTCGACCACAGCC
GTGGCTCGTGGCGAGGACGGGACTTCACCGGCACCGAGTATGTCGACGCCATTCGGGGCGACCTCAACGAACGACTTGCT
CGGCTCGGTCTGGCGTGA

Structures

Antitoxin

• AlphaFold DB: A0A8B5RUG0