Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 27455..27968 Replicon plasmid pSEBC1190-1
Accession NZ_CP090994
Organism Staphylococcus epidermidis strain BC1190

Toxin (Protein)


Gene name yoeB Uniprot ID A0A8B5RSL6
Locus tag KB234_RS11810 Protein ID WP_024054463.1
Coordinates 27455..27721 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A8B5RQB4
Locus tag KB234_RS11815 Protein ID WP_002452575.1
Coordinates 27714..27968 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KB234_RS11760 (KB234_11760) 22674..22853 + 180 WP_002456267.1 CsbD family protein -
KB234_RS11765 (KB234_11765) 22886..23032 - 147 WP_227946810.1 YolD-like family protein -
KB234_RS11770 (KB234_11770) 23046..23285 - 240 WP_227946811.1 YolD-like family protein -
KB234_RS11775 (KB234_11775) 23448..23705 + 258 WP_002441972.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
KB234_RS11780 (KB234_11780) 23705..23971 + 267 WP_029376511.1 Txe/YoeB family addiction module toxin -
KB234_RS11785 (KB234_11785) 23988..24158 + 171 WP_171049635.1 hypothetical protein -
KB234_RS11790 (KB234_11790) 24217..24744 + 528 WP_080280668.1 cellulase family glycosylhydrolase -
KB234_RS11795 (KB234_11795) 25245..25601 - 357 WP_002441965.1 hypothetical protein -
KB234_RS11800 (KB234_11800) 25915..26463 + 549 WP_029376510.1 recombinase family protein -
KB234_RS11805 (KB234_11805) 26832..27257 + 426 WP_229381335.1 CPBP family intramembrane metalloprotease -
KB234_RS11810 (KB234_11810) 27455..27721 - 267 WP_024054463.1 Txe/YoeB family addiction module toxin Toxin
KB234_RS11815 (KB234_11815) 27714..27968 - 255 WP_002452575.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
KB234_RS11820 (KB234_11820) 28431..29609 + 1179 WP_154224912.1 IS110-like element ISSep2 family transposase -
KB234_RS11825 (KB234_11825) 30129..30626 - 498 WP_049374138.1 hypothetical protein -
KB234_RS11830 (KB234_11830) 32103..32663 - 561 WP_029376507.1 TIGR00730 family Rossman fold protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..43054 43054
- flank IS/Tn - - 28536..29609 1073


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(4-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10481.13 Da        Isoelectric Point: 9.9964

>T232283 WP_024054463.1 NZ_CP090994:c27721-27455 [Staphylococcus epidermidis]
MNKYNITFTPTAFEDYKYWQTQDKKLLKKINSLIKSIQRDGILEGEGKAEPLKGNLKGYYSRRINHEHRLVYTIKDPSII
IIACRYHY

Download         Length: 267 bp

>T232283 NZ_CP127275:2301079-2301489 [Mycobacterium tuberculosis]
TTGGCTGAGCCACGGCGAGGAGACCTTTGGCTGGTCAGCCTCGGCGCCGCTCGCGCGGGTGAGCCCGGCAAGCATCGGCC
CGCGGTGGTCGTTTCCGTGGACGAGCTACTCACCGGAATCGACGACGAACTCGTTGTCGTCGTGCCGGTGTCAAGCTCGC
GCTCCCGCACCCCACTCCGGCCACCTGTCGCGCCCTCAGAAGGTGTAGCTGCCGATAGCGTCGCGGTGTGCCGCGGCGTC
CGCGCGGTCGCTCGTGCCCGACTCGTGGAGCGACTCGGCGCCCTCAAACCCGCCACGATGCGCGCAATCGAAAACGCCCT
GACCCTGATCCTCGGCCTCCCGACGGGACCTGAGCGCGGCGAGGCGGCGACCCATTCTCCCGTACGGTGGACGGGTGGCC
GGGACCCGTGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9651.68 Da        Isoelectric Point: 4.1237

>AT232283 WP_002452575.1 NZ_CP090994:c27968-27714 [Staphylococcus epidermidis]
MTVLTYSNARKDFRKLIDKVNDDSDTVTITTNDRNAVLISEDDYNSIMETLYLQQSPVNAKRLAQSMEEAERVNTVEVDI
TTYE

Download         Length: 255 bp

>AT232283 NZ_CP127275:2300853-2301086 [Mycobacterium tuberculosis]
ATGTCTACATCCACGACGATTAGGGTTTCAACCCAGACTCGGGATCGTCTGGCCGCCCAAGCCCGCGAACGGGGAATCTC
GATGTCGGCTCTGCTCACCGAACTGGCCGCCCAGGCCGAGCGCCAGGCAATCTTCCGCGCCGAACGCGAGGCCTCGCACG
CCGAGACGACCACCCAGGCAGTCCGCGACGAGGACCGCGAGTGGGAGGGCACGGTAGGCGACGGCCTTGGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8B5RSL6

Antitoxin

Source ID Structure
AlphaFold DB A0A8B5RQB4

References