Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yefM-yoeB (relBE)/Txe-RelB |
| Location | 27455..27968 | Replicon | plasmid pSEBC1190-1 |
| Accession | NZ_CP090994 | ||
| Organism | Staphylococcus epidermidis strain BC1190 | ||
Toxin (Protein)
| Gene name | yoeB | Uniprot ID | A0A8B5RSL6 |
| Locus tag | KB234_RS11810 | Protein ID | WP_024054463.1 |
| Coordinates | 27455..27721 (-) | Length | 89 a.a. |
Antitoxin (Protein)
| Gene name | yefM | Uniprot ID | A0A8B5RQB4 |
| Locus tag | KB234_RS11815 | Protein ID | WP_002452575.1 |
| Coordinates | 27714..27968 (-) | Length | 85 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KB234_RS11760 (KB234_11760) | 22674..22853 | + | 180 | WP_002456267.1 | CsbD family protein | - |
| KB234_RS11765 (KB234_11765) | 22886..23032 | - | 147 | WP_227946810.1 | YolD-like family protein | - |
| KB234_RS11770 (KB234_11770) | 23046..23285 | - | 240 | WP_227946811.1 | YolD-like family protein | - |
| KB234_RS11775 (KB234_11775) | 23448..23705 | + | 258 | WP_002441972.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| KB234_RS11780 (KB234_11780) | 23705..23971 | + | 267 | WP_029376511.1 | Txe/YoeB family addiction module toxin | - |
| KB234_RS11785 (KB234_11785) | 23988..24158 | + | 171 | WP_171049635.1 | hypothetical protein | - |
| KB234_RS11790 (KB234_11790) | 24217..24744 | + | 528 | WP_080280668.1 | cellulase family glycosylhydrolase | - |
| KB234_RS11795 (KB234_11795) | 25245..25601 | - | 357 | WP_002441965.1 | hypothetical protein | - |
| KB234_RS11800 (KB234_11800) | 25915..26463 | + | 549 | WP_029376510.1 | recombinase family protein | - |
| KB234_RS11805 (KB234_11805) | 26832..27257 | + | 426 | WP_229381335.1 | CPBP family intramembrane metalloprotease | - |
| KB234_RS11810 (KB234_11810) | 27455..27721 | - | 267 | WP_024054463.1 | Txe/YoeB family addiction module toxin | Toxin |
| KB234_RS11815 (KB234_11815) | 27714..27968 | - | 255 | WP_002452575.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| KB234_RS11820 (KB234_11820) | 28431..29609 | + | 1179 | WP_154224912.1 | IS110-like element ISSep2 family transposase | - |
| KB234_RS11825 (KB234_11825) | 30129..30626 | - | 498 | WP_049374138.1 | hypothetical protein | - |
| KB234_RS11830 (KB234_11830) | 32103..32663 | - | 561 | WP_029376507.1 | TIGR00730 family Rossman fold protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | - | 1..43054 | 43054 | |
| - | flank | IS/Tn | - | - | 28536..29609 | 1073 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 89 a.a. Molecular weight: 10481.13 Da Isoelectric Point: 9.9964
>T232283 WP_024054463.1 NZ_CP090994:c27721-27455 [Staphylococcus epidermidis]
MNKYNITFTPTAFEDYKYWQTQDKKLLKKINSLIKSIQRDGILEGEGKAEPLKGNLKGYYSRRINHEHRLVYTIKDPSII
IIACRYHY
MNKYNITFTPTAFEDYKYWQTQDKKLLKKINSLIKSIQRDGILEGEGKAEPLKGNLKGYYSRRINHEHRLVYTIKDPSII
IIACRYHY
Download Length: 267 bp
>T232283 NZ_CP127275:2301079-2301489 [Mycobacterium tuberculosis]
TTGGCTGAGCCACGGCGAGGAGACCTTTGGCTGGTCAGCCTCGGCGCCGCTCGCGCGGGTGAGCCCGGCAAGCATCGGCC
CGCGGTGGTCGTTTCCGTGGACGAGCTACTCACCGGAATCGACGACGAACTCGTTGTCGTCGTGCCGGTGTCAAGCTCGC
GCTCCCGCACCCCACTCCGGCCACCTGTCGCGCCCTCAGAAGGTGTAGCTGCCGATAGCGTCGCGGTGTGCCGCGGCGTC
CGCGCGGTCGCTCGTGCCCGACTCGTGGAGCGACTCGGCGCCCTCAAACCCGCCACGATGCGCGCAATCGAAAACGCCCT
GACCCTGATCCTCGGCCTCCCGACGGGACCTGAGCGCGGCGAGGCGGCGACCCATTCTCCCGTACGGTGGACGGGTGGCC
GGGACCCGTGA
TTGGCTGAGCCACGGCGAGGAGACCTTTGGCTGGTCAGCCTCGGCGCCGCTCGCGCGGGTGAGCCCGGCAAGCATCGGCC
CGCGGTGGTCGTTTCCGTGGACGAGCTACTCACCGGAATCGACGACGAACTCGTTGTCGTCGTGCCGGTGTCAAGCTCGC
GCTCCCGCACCCCACTCCGGCCACCTGTCGCGCCCTCAGAAGGTGTAGCTGCCGATAGCGTCGCGGTGTGCCGCGGCGTC
CGCGCGGTCGCTCGTGCCCGACTCGTGGAGCGACTCGGCGCCCTCAAACCCGCCACGATGCGCGCAATCGAAAACGCCCT
GACCCTGATCCTCGGCCTCCCGACGGGACCTGAGCGCGGCGAGGCGGCGACCCATTCTCCCGTACGGTGGACGGGTGGCC
GGGACCCGTGA
Antitoxin
Download Length: 85 a.a. Molecular weight: 9651.68 Da Isoelectric Point: 4.1237
>AT232283 WP_002452575.1 NZ_CP090994:c27968-27714 [Staphylococcus epidermidis]
MTVLTYSNARKDFRKLIDKVNDDSDTVTITTNDRNAVLISEDDYNSIMETLYLQQSPVNAKRLAQSMEEAERVNTVEVDI
TTYE
MTVLTYSNARKDFRKLIDKVNDDSDTVTITTNDRNAVLISEDDYNSIMETLYLQQSPVNAKRLAQSMEEAERVNTVEVDI
TTYE
Download Length: 255 bp
>AT232283 NZ_CP127275:2300853-2301086 [Mycobacterium tuberculosis]
ATGTCTACATCCACGACGATTAGGGTTTCAACCCAGACTCGGGATCGTCTGGCCGCCCAAGCCCGCGAACGGGGAATCTC
GATGTCGGCTCTGCTCACCGAACTGGCCGCCCAGGCCGAGCGCCAGGCAATCTTCCGCGCCGAACGCGAGGCCTCGCACG
CCGAGACGACCACCCAGGCAGTCCGCGACGAGGACCGCGAGTGGGAGGGCACGGTAGGCGACGGCCTTGGCTGA
ATGTCTACATCCACGACGATTAGGGTTTCAACCCAGACTCGGGATCGTCTGGCCGCCCAAGCCCGCGAACGGGGAATCTC
GATGTCGGCTCTGCTCACCGAACTGGCCGCCCAGGCCGAGCGCCAGGCAATCTTCCGCGCCGAACGCGAGGCCTCGCACG
CCGAGACGACCACCCAGGCAGTCCGCGACGAGGACCGCGAGTGGGAGGGCACGGTAGGCGACGGCCTTGGCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A8B5RSL6 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A8B5RQB4 |