Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | yefM-yoeB (relBE)/Txe-RelB |
Location | 23448..23971 | Replicon | plasmid pSEBC1190-1 |
Accession | NZ_CP090994 | ||
Organism | Staphylococcus epidermidis strain BC1190 |
Toxin (Protein)
Gene name | yoeB | Uniprot ID | A0A8B5RPI4 |
Locus tag | KB234_RS11780 | Protein ID | WP_029376511.1 |
Coordinates | 23705..23971 (+) | Length | 89 a.a. |
Antitoxin (Protein)
Gene name | yefM | Uniprot ID | C5QR06 |
Locus tag | KB234_RS11775 | Protein ID | WP_002441972.1 |
Coordinates | 23448..23705 (+) | Length | 86 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
KB234_RS11735 (KB234_11735) | 18620..18775 | - | 156 | WP_002452621.1 | hypothetical protein | - |
KB234_RS11740 (KB234_11740) | 19686..20507 | - | 822 | WP_049374124.1 | relaxase MobL | - |
KB234_RS11745 (KB234_11745) | 20519..20902 | - | 384 | WP_029376512.1 | hypothetical protein | - |
KB234_RS11750 (KB234_11750) | 20904..21284 | - | 381 | WP_235063564.1 | hypothetical protein | - |
KB234_RS11755 (KB234_11755) | 22131..22277 | - | 147 | WP_002441983.1 | hypothetical protein | - |
KB234_RS11760 (KB234_11760) | 22674..22853 | + | 180 | WP_002456267.1 | CsbD family protein | - |
KB234_RS11765 (KB234_11765) | 22886..23032 | - | 147 | WP_227946810.1 | YolD-like family protein | - |
KB234_RS11770 (KB234_11770) | 23046..23285 | - | 240 | WP_227946811.1 | YolD-like family protein | - |
KB234_RS11775 (KB234_11775) | 23448..23705 | + | 258 | WP_002441972.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
KB234_RS11780 (KB234_11780) | 23705..23971 | + | 267 | WP_029376511.1 | Txe/YoeB family addiction module toxin | Toxin |
KB234_RS11785 (KB234_11785) | 23988..24158 | + | 171 | WP_171049635.1 | hypothetical protein | - |
KB234_RS11790 (KB234_11790) | 24217..24744 | + | 528 | WP_080280668.1 | cellulase family glycosylhydrolase | - |
KB234_RS11795 (KB234_11795) | 25245..25601 | - | 357 | WP_002441965.1 | hypothetical protein | - |
KB234_RS11800 (KB234_11800) | 25915..26463 | + | 549 | WP_029376510.1 | recombinase family protein | - |
KB234_RS11805 (KB234_11805) | 26832..27257 | + | 426 | WP_229381335.1 | CPBP family intramembrane metalloprotease | - |
KB234_RS11810 (KB234_11810) | 27455..27721 | - | 267 | WP_024054463.1 | Txe/YoeB family addiction module toxin | - |
KB234_RS11815 (KB234_11815) | 27714..27968 | - | 255 | WP_002452575.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Non-Mobilizable plasmid | - | - | 1..43054 | 43054 | |
- | flank | IS/Tn | - | - | 28536..29609 | 1073 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 89 a.a. Molecular weight: 10721.38 Da Isoelectric Point: 10.3481
>T232282 WP_029376511.1 NZ_CP090994:23705-23971 [Staphylococcus epidermidis]
MAKYKINIKNSAKTDLKKIKRSHLQEQFLKIVEILKYNPYQQSQSFEKLHPKHLGRYSRRINHQHRVVYTIDEENKEVLI
LATWSHYE
MAKYKINIKNSAKTDLKKIKRSHLQEQFLKIVEILKYNPYQQSQSFEKLHPKHLGRYSRRINHQHRVVYTIDEENKEVLI
LATWSHYE
Download Length: 267 bp
>T232282 NZ_CP127275:2238295-2238693 [Mycobacterium tuberculosis]
ATGATCGTCGACACCTCGGTCTGGATCGCATATCTCTCCACGTCAGAGTCGTTGGCCAGTCGCTGGCTAGCCGATCGCAT
TGCCGCTGACTCGACGGTGATCGTGCCCGAGGTGGTGATGATGGAGCTGCTGATCGGTAAGACCGATGAGGACACCGCCG
CACTGCGCCGACGGCTCCTGCAGCGATTCGCTATCGAACCGCTGGCCCCGGTCCGCGACGCGGAAGATGCCGCCGCCATT
CACCGGCGCTGTCGTCGCGGCGGCGACACCGTACGCAGCCTGATCGATTGCCAGGTGGCCGCGATGGCGTTGCGGATCGG
GGTCGCCGTGGCGCATCGTGATCGCGACTACGAGGCGATCCGCACACATTGCGGACTACGCACCGAGCCGTTGTTCTGA
ATGATCGTCGACACCTCGGTCTGGATCGCATATCTCTCCACGTCAGAGTCGTTGGCCAGTCGCTGGCTAGCCGATCGCAT
TGCCGCTGACTCGACGGTGATCGTGCCCGAGGTGGTGATGATGGAGCTGCTGATCGGTAAGACCGATGAGGACACCGCCG
CACTGCGCCGACGGCTCCTGCAGCGATTCGCTATCGAACCGCTGGCCCCGGTCCGCGACGCGGAAGATGCCGCCGCCATT
CACCGGCGCTGTCGTCGCGGCGGCGACACCGTACGCAGCCTGATCGATTGCCAGGTGGCCGCGATGGCGTTGCGGATCGG
GGTCGCCGTGGCGCATCGTGATCGCGACTACGAGGCGATCCGCACACATTGCGGACTACGCACCGAGCCGTTGTTCTGA
Antitoxin
Download Length: 86 a.a. Molecular weight: 10041.10 Da Isoelectric Point: 4.5610
>AT232282 WP_002441972.1 NZ_CP090994:23448-23705 [Staphylococcus epidermidis]
MKSKTPTEARKDFYQLLKRVNNDHEPVYIEGKYDESNAVIIGMEDWRSINETIYLEATGTMDKVREREHDNSGYTNIDDI
DWARL
MKSKTPTEARKDFYQLLKRVNNDHEPVYIEGKYDESNAVIIGMEDWRSINETIYLEATGTMDKVREREHDNSGYTNIDDI
DWARL
Download Length: 258 bp
>AT232282 NZ_CP127275:2238067-2238294 [Mycobacterium tuberculosis]
GTGTCACGGACCAACATCGAGATCGACGACGAACTCGTGGCCGCCGCACAGCGGATGTACCGACTCGATTCCAAGCGAAG
TGCCGTCGACCTCGCGCTGCGCCGGCTCGTGGGTGAACCGTTGGGCCGCGATGAGGCTTTGGCGCTGCAGGGCAGCGGTT
TCGACTTCAGCAACGATGAGATCGAATCGTTCTCGGATACGGACCGCAAGCTCGCCGACGAGTCGTAG
GTGTCACGGACCAACATCGAGATCGACGACGAACTCGTGGCCGCCGCACAGCGGATGTACCGACTCGATTCCAAGCGAAG
TGCCGTCGACCTCGCGCTGCGCCGGCTCGTGGGTGAACCGTTGGGCCGCGATGAGGCTTTGGCGCTGCAGGGCAGCGGTT
TCGACTTCAGCAACGATGAGATCGAATCGTTCTCGGATACGGACCGCAAGCTCGCCGACGAGTCGTAG
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A8B5RPI4 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A8B5RUG0 |