232273

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 37967..38490 Replicon plasmid pSE50D-1
Accession NZ_CP090986
Organism Staphylococcus epidermidis strain 50D

Toxin (Protein)


Gene name yoeB Uniprot ID A0A8B5RPI4
Locus tag KB226_RS11885 Protein ID WP_029376511.1
Coordinates 38224..38490 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID C5QR06
Locus tag KB226_RS11880 Protein ID WP_002441972.1
Coordinates 37967..38224 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KB226_RS11850 (KB226_11850) 34205..35026 - 822 WP_049374124.1 relaxase MobL -
KB226_RS11855 (KB226_11855) 35038..35421 - 384 WP_029376512.1 hypothetical protein -
KB226_RS11860 (KB226_11860) 35423..35803 - 381 WP_235063564.1 hypothetical protein -
KB226_RS11865 (KB226_11865) 37193..37372 + 180 WP_002456267.1 CsbD family protein -
KB226_RS11870 (KB226_11870) 37405..37551 - 147 WP_227946810.1 YolD-like family protein -
KB226_RS11875 (KB226_11875) 37565..37804 - 240 WP_227946811.1 YolD-like family protein -
KB226_RS11880 (KB226_11880) 37967..38224 + 258 WP_002441972.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
KB226_RS11885 (KB226_11885) 38224..38490 + 267 WP_029376511.1 Txe/YoeB family addiction module toxin Toxin
KB226_RS11890 (KB226_11890) 38507..38677 + 171 WP_171049635.1 hypothetical protein -
KB226_RS11895 (KB226_11895) 38736..39263 + 528 WP_080280668.1 cellulase family glycosylhydrolase -
KB226_RS11900 (KB226_11900) 39764..40120 - 357 WP_002441965.1 hypothetical protein -
KB226_RS11905 (KB226_11905) 40434..40982 + 549 WP_029376510.1 recombinase family protein -
KB226_RS11910 (KB226_11910) 41351..41776 + 426 WP_229381335.1 CPBP family intramembrane metalloprotease -
KB226_RS11915 (KB226_11915) 41974..42240 - 267 WP_024054463.1 Txe/YoeB family addiction module toxin -
KB226_RS11920 (KB226_11920) 42233..42487 - 255 WP_002452575.1 type II toxin-antitoxin system Phd/YefM family antitoxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..43054 43054


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(9-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-67)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10721.38 Da        Isoelectric Point: 10.3481

>T232273 WP_029376511.1 NZ_CP090986:38224-38490 [Staphylococcus epidermidis]
MAKYKINIKNSAKTDLKKIKRSHLQEQFLKIVEILKYNPYQQSQSFEKLHPKHLGRYSRRINHQHRVVYTIDEENKEVLI
LATWSHYE

Download         Length: 267 bp

>T232273 NZ_CP127275:1761249-1761653 [Mycobacterium tuberculosis]
ATGATCCTCATCGACACATCGGCCTGGGTGGAGTACTTCCGTGCCACCGGATCAATCGCCGCTGTCGAAGTACGCCGGCT
GCTGTCCGAAGAAGCAGCGCGAATCGCTATGTGTGAGCCCATTGCGATGGAAATCTTGAGTGGCGCGCTCGACGACAACA
CCCACACGACGCTAGAGCGGCTCGTGAATGGCTTGCCGTCGTTGAACGTTGATGACGCGATTGACTTTCGTGCTGCCGCG
GGTATCTATCGCGCCGCCCGGCGCGCCGGCGAAACGGTTCGAAGCATCAACGACTGCCTCATAGCGGCGCTCGCGATCCG
CCACGGTGCGCGTATCGTCCACCGTGACGCCGACTTTGATGTGATTGCCCGGATTACCAACCTGCAGGCCGCATCGTTTC
GGTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10041.10 Da        Isoelectric Point: 4.5610

>AT232273 WP_002441972.1 NZ_CP090986:37967-38224 [Staphylococcus epidermidis]
MKSKTPTEARKDFYQLLKRVNNDHEPVYIEGKYDESNAVIIGMEDWRSINETIYLEATGTMDKVREREHDNSGYTNIDDI
DWARL

Download         Length: 258 bp

>AT232273 NZ_CP127275:1761040-1761243 [Mycobacterium tuberculosis]
ATGTCGCGCACCAACATCGACATCGATGACGAACTTGCCGCCGAGGTCATGCGCAGGTTCGGTCTGACCACCAAGAGGGC
GGCGGTCGACCTTGCCCTACGACGGTTGGTCGGGTCGCCGTTGAGCCGTGAGTTTCTGCTCGGGCTGGAAGGCGTCGGCT
GGGAAGGCGACCTGGATGACTTGCGAAGCGATCGCCCAGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8B5RPI4

Antitoxin

Source ID Structure
AlphaFold DB A0A8B5RUG0

References