Detailed information of TA system TA232252

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/Tad-HTH_37
• Location: 1727037..1727664
• Replicon: chromosome
• Accession: NZ_CP090968
• Organism: Edwardsiella piscicida strain 18EpOKYJ

Toxin (Protein)

• Gene name: higB
• Uniprot ID: A0A411H7J1
• Locus tag: L1P05_RS07955
• Protein ID: WP_015871332.1
• Coordinates: 1727335..1727664 (-)
• Length: 110 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: L1P05_RS07950
• Protein ID: WP_005286394.1
• Coordinates: 1727037..1727345 (-)
• Length: 103 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L1P05_RS07900 (L1P05_07900)	1722072..1722764	-	693	WP_041692511.1	helix-turn-helix transcriptional regulator	-
L1P05_RS07905 (L1P05_07905)	1722869..1723084	+	216	WP_012848463.1	YdaS family helix-turn-helix protein	-
L1P05_RS07910 (L1P05_07910)	1723182..1723538	+	357	WP_012848464.1	hypothetical protein	-
L1P05_RS07915 (L1P05_07915)	1723535..1723768	+	234	WP_005286423.1	hypothetical protein	-
L1P05_RS07920 (L1P05_07920)	1723800..1724051	+	252	WP_012848465.1	hypothetical protein	-
L1P05_RS07925 (L1P05_07925)	1724254..1725252	+	999	WP_012848466.1	DUF1367 family protein	-
L1P05_RS07930 (L1P05_07930)	1725255..1725557	+	303	WP_012848467.1	DUF1364 family protein	-
L1P05_RS07935 (L1P05_07935)	1725846..1726091	+	246	WP_012848468.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
L1P05_RS07940 (L1P05_07940)	1725979..1726347	+	369	WP_196796969.1	Txe/YoeB family addiction module toxin	-
L1P05_RS07945 (L1P05_07945)	1726430..1726942	-	513	WP_012848469.1	DUF2442 domain-containing protein	-
L1P05_RS07950 (L1P05_07950)	1727037..1727345	-	309	WP_005286394.1	helix-turn-helix transcriptional regulator	Antitoxin
L1P05_RS07955 (L1P05_07955)	1727335..1727664	-	330	WP_015871332.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
L1P05_RS07960 (L1P05_07960)	1728139..1728732	+	594	WP_012848471.1	hypothetical protein	-
L1P05_RS07965 (L1P05_07965)	1728904..1729242	+	339	WP_012848472.1	phage holin, lambda family	-
L1P05_RS07970 (L1P05_07970)	1729245..1729796	+	552	WP_012848473.1	glycosyl hydrolase 108 family protein	-
L1P05_RS07975 (L1P05_07975)	1729986..1730768	+	783	WP_045475170.1	antA/AntB antirepressor family protein	-
L1P05_RS07980 (L1P05_07980)	1730871..1731416	+	546	WP_041692512.1	DUF2514 family protein	-
L1P05_RS07985 (L1P05_07985)	1731773..1732549	+	777	WP_012848476.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1699645..1745698	46053

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (16-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (44-97)

Sequences

Toxin

Protein

• Length: 110 a.a.
• Molecular weight: 12771.78 Da
• Isoelectric Point: 9.6247

>T232252 WP_015871332.1 NZ_CP090968:c1727664-1727335 [Edwardsiella piscicida]
MNYTIEYYSEEVRLEVDQLPMGMRVRYQHLVERMEIYGSNLGEPHTSPFGDGLFELRIKGSDGIARVFYCTLTGKRIVML
HSFIKKTQKTPSAERKKAETRMKEVKHGW

Nucleotide

• Length: 330 bp

>T232252 NZ_CP127275:674439-674846 [Mycobacterium tuberculosis]
GTGATCATCGACACGAGTGCGCTGCTTGCCTATTTCGACGCCGCCGAGCCAGACCACGCCGCAGTGTCTGAGTGCATCGA
TAGCTCCGCAGACGCGCTCGTCGTATCCCCTTATGTGGTAGCGGAACTCGACTATCTCGTCGCCACCCGGGTAGGTGTCG
ATGCCGAGCTCGCCGTCCTGCGTGAACTCGCCGGCGGGGCCTGGGAGCTCGCCAACTGCGGTGCCGCCGAAATCGAGCAG
GCCGCCCGCATCGTCACGAAATACCAGGATCAGCGGATCGGGATCGCGGATGCGGCCAACGTCGTGCTGGCCGACCGATA
CCGCACGCGCACGATCCTCACCCTGGACCGTCGGCACTTCTCGGCGCTGCGGCCGATCGGCGGTGGGCGCTTCACCGTCA
TTCCGTAA

Antitoxin

Protein

• Length: 103 a.a.
• Molecular weight: 11233.90 Da
• Isoelectric Point: 8.5371

>AT232252 WP_005286394.1 NZ_CP090968:c1727345-1727037 [Edwardsiella piscicida]
MAGKRTPPTMTHDEMAAKWMEDPAFKAEYDAIEEEYALLDEMLAARKNAGLTQAQVAERMGTKPTAITRMESNLASGQSG
PSFATLKKFAHATGKKLQIRFV

Nucleotide

• Length: 309 bp

>AT232252 NZ_CP127275:674227-674442 [Mycobacterium tuberculosis]
GTGGACAAGACGACGGTCTACCTGCCGGATGAACTCAAGGCGGCCGTGAAGCGCGCCGCTCGGCAGCGCGGAGTCTCCGA
AGCGCAGGTAATCCGGGAGTCCATCCGGGCGGCGGTCGGCGGCGCCAAGCCGCCGCCGCGCGGGGGTCTATATGCGGGTT
CGGAGCCCATCGCGCGGCGAGTCGACGAGCTGCTGGCTGGCTTCGGTGAGCGGTGA

Structures

Toxin

• AlphaFold DB: A0A411H7J1