Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/Tad-HTH_37 |
| Location | 1727031..1727658 | Replicon | chromosome |
| Accession | NZ_CP090967 | ||
| Organism | Edwardsiella piscicida strain KE5 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | A0A411H7J1 |
| Locus tag | L1P07_RS07955 | Protein ID | WP_015871332.1 |
| Coordinates | 1727329..1727658 (-) | Length | 110 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | L1P07_RS07950 | Protein ID | WP_005286394.1 |
| Coordinates | 1727031..1727339 (-) | Length | 103 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| L1P07_RS07900 (L1P07_07900) | 1722066..1722758 | - | 693 | WP_041692511.1 | helix-turn-helix transcriptional regulator | - |
| L1P07_RS07905 (L1P07_07905) | 1722863..1723078 | + | 216 | WP_012848463.1 | YdaS family helix-turn-helix protein | - |
| L1P07_RS07910 (L1P07_07910) | 1723176..1723532 | + | 357 | WP_012848464.1 | hypothetical protein | - |
| L1P07_RS07915 (L1P07_07915) | 1723529..1723762 | + | 234 | WP_005286423.1 | hypothetical protein | - |
| L1P07_RS07920 (L1P07_07920) | 1723794..1724045 | + | 252 | WP_012848465.1 | hypothetical protein | - |
| L1P07_RS07925 (L1P07_07925) | 1724248..1725246 | + | 999 | WP_012848466.1 | DUF1367 family protein | - |
| L1P07_RS07930 (L1P07_07930) | 1725249..1725551 | + | 303 | WP_012848467.1 | DUF1364 family protein | - |
| L1P07_RS07935 (L1P07_07935) | 1725840..1726085 | + | 246 | WP_012848468.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| L1P07_RS07940 (L1P07_07940) | 1725973..1726341 | + | 369 | WP_196796969.1 | Txe/YoeB family addiction module toxin | - |
| L1P07_RS07945 (L1P07_07945) | 1726424..1726936 | - | 513 | WP_012848469.1 | DUF2442 domain-containing protein | - |
| L1P07_RS07950 (L1P07_07950) | 1727031..1727339 | - | 309 | WP_005286394.1 | helix-turn-helix transcriptional regulator | Antitoxin |
| L1P07_RS07955 (L1P07_07955) | 1727329..1727658 | - | 330 | WP_015871332.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| L1P07_RS07960 (L1P07_07960) | 1728133..1728726 | + | 594 | WP_012848471.1 | hypothetical protein | - |
| L1P07_RS07965 (L1P07_07965) | 1728898..1729236 | + | 339 | WP_012848472.1 | phage holin, lambda family | - |
| L1P07_RS07970 (L1P07_07970) | 1729239..1729790 | + | 552 | WP_012848473.1 | glycosyl hydrolase 108 family protein | - |
| L1P07_RS07975 (L1P07_07975) | 1729980..1730762 | + | 783 | WP_045475170.1 | antA/AntB antirepressor family protein | - |
| L1P07_RS07980 (L1P07_07980) | 1730865..1731410 | + | 546 | WP_041692512.1 | DUF2514 family protein | - |
| L1P07_RS07985 (L1P07_07985) | 1731767..1732543 | + | 777 | WP_012848476.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 1699639..1745692 | 46053 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 110 a.a. Molecular weight: 12771.78 Da Isoelectric Point: 9.6247
>T232239 WP_015871332.1 NZ_CP090967:c1727658-1727329 [Edwardsiella piscicida]
MNYTIEYYSEEVRLEVDQLPMGMRVRYQHLVERMEIYGSNLGEPHTSPFGDGLFELRIKGSDGIARVFYCTLTGKRIVML
HSFIKKTQKTPSAERKKAETRMKEVKHGW
MNYTIEYYSEEVRLEVDQLPMGMRVRYQHLVERMEIYGSNLGEPHTSPFGDGLFELRIKGSDGIARVFYCTLTGKRIVML
HSFIKKTQKTPSAERKKAETRMKEVKHGW
Download Length: 330 bp
>T232239 NZ_CP127274:3161707-3161970 [Mycobacterium tuberculosis]
GTGCCTTACACCGTGCGGTTCACCACAACCGCGCGTCGAGACCTCCACAAGCTGCCACCGCGAATCCTCGCGGCAGTGGT
CGAATTCGCGTTCGGCGATCTGTCGCGCGAGCCCCTGCGGGTGGGCAAGCCCCTTCGGCGCGAGTTGGCCGGCACGTTCA
GCGCGCGTCGCGGAACGTACCGCCTGCTGTACCGGATTGACGACGAGCACACAACGGTAGTGATCCTGCGCGTCGATCAC
CGCGCGGACATCTACCGCCGATAG
GTGCCTTACACCGTGCGGTTCACCACAACCGCGCGTCGAGACCTCCACAAGCTGCCACCGCGAATCCTCGCGGCAGTGGT
CGAATTCGCGTTCGGCGATCTGTCGCGCGAGCCCCTGCGGGTGGGCAAGCCCCTTCGGCGCGAGTTGGCCGGCACGTTCA
GCGCGCGTCGCGGAACGTACCGCCTGCTGTACCGGATTGACGACGAGCACACAACGGTAGTGATCCTGCGCGTCGATCAC
CGCGCGGACATCTACCGCCGATAG
Antitoxin
Download Length: 103 a.a. Molecular weight: 11233.90 Da Isoelectric Point: 8.5371
>AT232239 WP_005286394.1 NZ_CP090967:c1727339-1727031 [Edwardsiella piscicida]
MAGKRTPPTMTHDEMAAKWMEDPAFKAEYDAIEEEYALLDEMLAARKNAGLTQAQVAERMGTKPTAITRMESNLASGQSG
PSFATLKKFAHATGKKLQIRFV
MAGKRTPPTMTHDEMAAKWMEDPAFKAEYDAIEEEYALLDEMLAARKNAGLTQAQVAERMGTKPTAITRMESNLASGQSG
PSFATLKKFAHATGKKLQIRFV
Download Length: 309 bp
>AT232239 NZ_CP127274:3161422-3161703 [Mycobacterium tuberculosis]
ATGCGGATACTGCCGATTTCGACGATCAAGGGCAAGCTCAATGAGTTCGTCGACGCGGTCTCGTCGACACAGGACCAGAT
CACCATCACCAAGAACGGTGCACCCGCAGCCGTTCTGGTCGGCGCCGACGAGTGGGAATCGTTGCAGGAGACGCTGTACT
GGCTGGCGCAACCCGGAATCAGGGAGTCGATCGCTGAAGCCGACGCCGACATTGCCTCCGGCCGCACCTACGGCGAAGAC
GAGATCCGCGCCGAATTCGGCGTCCCGCGACGCCCCCACTGA
ATGCGGATACTGCCGATTTCGACGATCAAGGGCAAGCTCAATGAGTTCGTCGACGCGGTCTCGTCGACACAGGACCAGAT
CACCATCACCAAGAACGGTGCACCCGCAGCCGTTCTGGTCGGCGCCGACGAGTGGGAATCGTTGCAGGAGACGCTGTACT
GGCTGGCGCAACCCGGAATCAGGGAGTCGATCGCTGAAGCCGACGCCGACATTGCCTCCGGCCGCACCTACGGCGAAGAC
GAGATCCGCGCCGAATTCGGCGTCCCGCGACGCCCCCACTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|