Detailed information of TA system TA232185

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HTH(antitoxin)
• Location: 4823433..4824035
• Replicon: chromosome
• Accession: NZ_CP090930
• Organism: Salmonella enterica subsp. enterica serovar Agona strain R21.2430

Toxin (Protein)

• Gene name: higB
• Uniprot ID: V7IUJ1
• Locus tag: L1L23_RS23660
• Protein ID: WP_001159632.1
• Coordinates: 4823724..4824035 (-)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: L1L23_RS23655
• Protein ID: WP_000362051.1
• Coordinates: 4823433..4823723 (-)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L1L23_RS23640 (4820926)	4820926..4821828	+	903	WP_000331364.1	formate dehydrogenase subunit beta	-
L1L23_RS23645 (4821825)	4821825..4822460	+	636	WP_000829025.1	formate dehydrogenase cytochrome b556 subunit	-
L1L23_RS23650 (4822457)	4822457..4823386	+	930	WP_000027730.1	formate dehydrogenase accessory protein FdhE	-
L1L23_RS23655 (4823433)	4823433..4823723	-	291	WP_000362051.1	NadS family protein	Antitoxin
L1L23_RS23660 (4823724)	4823724..4824035	-	312	WP_001159632.1	cytotoxic translational repressor of toxin-antitoxin stability system	Toxin
L1L23_RS23665 (4824253)	4824253..4825182	+	930	WP_001127697.1	alpha/beta hydrolase	-
L1L23_RS23670 (4825268)	4825268..4825579	+	312	WP_000558166.1	type II toxin-antitoxin system HigB family toxin	-
L1L23_RS23675 (4825576)	4825576..4826022	+	447	WP_001259011.1	type II toxin-antitoxin system HigA family antitoxin	-
L1L23_RS23680 (4826037)	4826037..4826978	-	942	WP_001518251.1	fatty acid biosynthesis protein FabY	-
L1L23_RS23685 (4827023)	4827023..4827460	-	438	WP_000560973.1	D-aminoacyl-tRNA deacylase	-
L1L23_RS23690 (4827457)	4827457..4828329	-	873	WP_000921423.1	virulence factor BrkB family protein	-
L1L23_RS23695 (4828323)	4828323..4828922	-	600	WP_000965695.1	glucose-1-phosphatase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (36-85)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 12342.27 Da
• Isoelectric Point: 9.4460

>T232185 WP_001159632.1 NZ_CP090930:c4824035-4823724 [Salmonella enterica subsp. enterica serovar Agona]
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGSRGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Nucleotide

• Length: 312 bp

>T232185 NZ_CP127273:3754022-3754279 [Mycobacterium tuberculosis]
GTGAGAAGCGTCAACTTCGATCCCGATGCCTGGGAGGACTTCTTGTTCTGGCTGGCCGCTGATCGCAAAACGGCCCGTCG
GATCACCCGGTTGATCGGAGAAATTCAGCGTGATCCGTTCAGCGGGATCGGCAAACCCGAGCCGCTCCAAGGTGAGTTGT
CGGGATACTGGTCGCGCCGGATCGACGACGAACACCGGCTGGTGTATCGAGCGGGCGACGACGAAGTCACGATGCTGAAG
GCCCGATACCACTACTGA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10957.57 Da
• Isoelectric Point: 10.6525

>AT232185 WP_000362051.1 NZ_CP090930:c4823723-4823433 [Salmonella enterica subsp. enterica serovar Agona]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKVKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Nucleotide

• Length: 291 bp

>AT232185 NZ_CP127273:3753750-3754025 [Mycobacterium tuberculosis]
ATGAGCATCAGTGCGAGCGAGGCGAGGCAGCGCCTGTTTCCACTCATCGAACAGGTCAATACCGATCACCAGCCGGTGCG
GATCACCTCCCGGGCCGGCGATGCGGTGCTGATGTCCGCCGACGACTACGACGCGTGGCAGGAAACGGTCTATCTGCTGC
GCTCACCGGAGAACGCCAGGCGGTTGATGGAAGCGGTTGCCCGGGATAAGGCTGGGCACTCGGCTTTCACCAAGTCTGTA
GATGAGCTGCGGGAGATGGCCGGCGGCGAGGAGTGA

Structures

Toxin

• AlphaFold DB: A0A4U7VQ31