Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
| Location | 2910264..2910991 | Replicon | chromosome |
| Accession | NZ_CP090930 | ||
| Organism | Salmonella enterica subsp. enterica serovar Agona strain R21.2430 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | V7IQW2 |
| Locus tag | L1L23_RS14420 | Protein ID | WP_000558158.1 |
| Coordinates | 2910264..2910575 (+) | Length | 104 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | L1L23_RS14425 | Protein ID | WP_000561389.1 |
| Coordinates | 2910572..2910991 (+) | Length | 140 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| L1L23_RS14385 (2905431) | 2905431..2906153 | - | 723 | WP_000182066.1 | SPI-1 type III secretion system guanine nucleotide exchange factor SopE2 | - |
| L1L23_RS14390 (2906838) | 2906838..2907233 | + | 396 | WP_000422887.1 | DUF1398 domain-containing protein | - |
| L1L23_RS14395 (2907562) | 2907562..2908038 | + | 477 | WP_000030944.1 | hypothetical protein | - |
| L1L23_RS14400 (2908148) | 2908148..2908342 | + | 195 | WP_023134800.1 | hypothetical protein | - |
| L1L23_RS14405 (2908705) | 2908705..2909487 | + | 783 | WP_001747695.1 | DUF2971 domain-containing protein | - |
| L1L23_RS14410 (2909541) | 2909541..2909756 | - | 216 | WP_001747696.1 | hypothetical protein | - |
| L1L23_RS14415 (2909786) | 2909786..2910085 | - | 300 | WP_000775225.1 | hypothetical protein | - |
| L1L23_RS14420 (2910264) | 2910264..2910575 | + | 312 | WP_000558158.1 | type II toxin-antitoxin system HigB family toxin | Toxin |
| L1L23_RS14425 (2910572) | 2910572..2910991 | + | 420 | WP_000561389.1 | helix-turn-helix domain-containing protein | Antitoxin |
| L1L23_RS14430 (2911247) | 2911247..2911741 | + | 495 | WP_016419152.1 | glycosyltransferase | - |
| L1L23_RS24670 (2911738) | 2911738..2911896 | + | 159 | WP_023165344.1 | lipopolysaccharide 1,2-N-acetylglucosaminetransferase | - |
| L1L23_RS14435 (2912132) | 2912132..2912551 | - | 420 | WP_000354404.1 | GNAT family N-acetyltransferase | - |
| L1L23_RS14440 (2912922) | 2912922..2913191 | + | 270 | WP_077905753.1 | hypothetical protein | - |
| L1L23_RS14445 (2913357) | 2913357..2913497 | + | 141 | WP_000489598.1 | hypothetical protein | - |
| L1L23_RS14450 (2913643) | 2913643..2914185 | - | 543 | Protein_2838 | IS256 family transposase | - |
| L1L23_RS14455 (2914205) | 2914205..2914297 | - | 93 | WP_231923105.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | flank | IS/Tn | - | - | 2913643..2914320 | 677 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 104 a.a. Molecular weight: 12398.19 Da Isoelectric Point: 10.0279
>T232169 WP_000558158.1 NZ_CP090930:2910264-2910575 [Salmonella enterica subsp. enterica serovar Agona]
MHVISKEPFDEAARRYPNDSLAIKALYRLVREKDFSSPAELRTVIPSLDNFKYRNKWWVLDVGGNNLRVIAYINFINKRF
YVKHIATHAEYDKLTRYYRENKE
MHVISKEPFDEAARRYPNDSLAIKALYRLVREKDFSSPAELRTVIPSLDNFKYRNKWWVLDVGGNNLRVIAYINFINKRF
YVKHIATHAEYDKLTRYYRENKE
Download Length: 312 bp
>T232169 NZ_CP127273:2791292-2791717 [Mycobacterium tuberculosis]
GTGGCGCTGCTCGACGTCAACGCATTGGTCGCGCTGGCGTGGGACTCACACATCCACCACGCCCGGATCCGCGAGTGGTT
TACCGCCAACGCCACGCTCGGCTGGGCGACTTGCCCGCTCACCGAAGCCGGCTTCGTGCGGGCGTCGACGAACCCAAAAG
TACTTCCCAGCGCGATCGGGATCGCAGACGCTCGACGGGTCCTCGTGGCACTACGCGCCGTGGGAGGCCACCGCTTCCTG
GCTGACGACGTATCGCTCGTCGATGACGATGTTCCGTTGATCGTCGGTTATCGCCAGGTGACCGACGCCCATCTGCTGAC
ACTCGCCCGCCGGCGCGGCGTCCGCCTGGTCACCTTCGACGCCGGTGTCTTCACCCTCGCCCAACAACGCCCCAAGACGC
CAGTGGAGCTGCTGACCATCCTCTAA
GTGGCGCTGCTCGACGTCAACGCATTGGTCGCGCTGGCGTGGGACTCACACATCCACCACGCCCGGATCCGCGAGTGGTT
TACCGCCAACGCCACGCTCGGCTGGGCGACTTGCCCGCTCACCGAAGCCGGCTTCGTGCGGGCGTCGACGAACCCAAAAG
TACTTCCCAGCGCGATCGGGATCGCAGACGCTCGACGGGTCCTCGTGGCACTACGCGCCGTGGGAGGCCACCGCTTCCTG
GCTGACGACGTATCGCTCGTCGATGACGATGTTCCGTTGATCGTCGGTTATCGCCAGGTGACCGACGCCCATCTGCTGAC
ACTCGCCCGCCGGCGCGGCGTCCGCCTGGTCACCTTCGACGCCGGTGTCTTCACCCTCGCCCAACAACGCCCCAAGACGC
CAGTGGAGCTGCTGACCATCCTCTAA
Antitoxin
Download Length: 140 a.a. Molecular weight: 15301.49 Da Isoelectric Point: 4.6286
>AT232169 WP_000561389.1 NZ_CP090930:2910572-2910991 [Salmonella enterica subsp. enterica serovar Agona]
MIANTAKAIEATKALVAAVPFLGGSASEKDYRDALALVDYLIENDDENPLIDFLASKIAEYEDNSKQFAEFNKSVAEMPV
GVALLRTLIDQYKLSYSDLKEEIGSKSLVSQILSGQRSLTITHIKALSARFGVKPEWFL
MIANTAKAIEATKALVAAVPFLGGSASEKDYRDALALVDYLIENDDENPLIDFLASKIAEYEDNSKQFAEFNKSVAEMPV
GVALLRTLIDQYKLSYSDLKEEIGSKSLVSQILSGQRSLTITHIKALSARFGVKPEWFL
Download Length: 420 bp
>AT232169 NZ_CP127273:2791065-2791286 [Mycobacterium tuberculosis]
GTGCGAACGACACTTGACCTTGACGACGATGTGATCGCCGCGGCACGTGAACTTGCCTCCAGCCAGCGCCGCTCGCTCGG
CTCGGTGATTTCCGAACTCGCACGCCGTGGTCTCATGCCCGGACGCGTCGAGGCTGACGACGGGCTGCCGGTGATCCGCG
TTCCAGCCGGGACCCCGCCGATCACACCGGAGATGGTCCGTCGCGCGCTCGATGAGGACTGA
GTGCGAACGACACTTGACCTTGACGACGATGTGATCGCCGCGGCACGTGAACTTGCCTCCAGCCAGCGCCGCTCGCTCGG
CTCGGTGATTTCCGAACTCGCACGCCGTGGTCTCATGCCCGGACGCGTCGAGGCTGACGACGGGCTGCCGGTGATCCGCG
TTCCAGCCGGGACCCCGCCGATCACACCGGAGATGGTCCGTCGCGCGCTCGATGAGGACTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|