Detailed information of TA system TA232162

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HTH(antitoxin)
• Location: 4825964..4826566
• Replicon: chromosome
• Accession: NZ_CP090929
• Organism: Salmonella enterica subsp. enterica serovar Agona strain R21.2429

Toxin (Protein)

• Gene name: higB
• Uniprot ID: V7IUJ1
• Locus tag: L1L24_RS23675
• Protein ID: WP_001159632.1
• Coordinates: 4826255..4826566 (-)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: L1L24_RS23670
• Protein ID: WP_000362051.1
• Coordinates: 4825964..4826254 (-)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L1L24_RS23655 (4823457)	4823457..4824359	+	903	WP_000331364.1	formate dehydrogenase subunit beta	-
L1L24_RS23660 (4824356)	4824356..4824991	+	636	WP_000829025.1	formate dehydrogenase cytochrome b556 subunit	-
L1L24_RS23665 (4824988)	4824988..4825917	+	930	WP_000027730.1	formate dehydrogenase accessory protein FdhE	-
L1L24_RS23670 (4825964)	4825964..4826254	-	291	WP_000362051.1	NadS family protein	Antitoxin
L1L24_RS23675 (4826255)	4826255..4826566	-	312	WP_001159632.1	cytotoxic translational repressor of toxin-antitoxin stability system	Toxin
L1L24_RS23680 (4826784)	4826784..4827713	+	930	WP_001127697.1	alpha/beta hydrolase	-
L1L24_RS23685 (4827799)	4827799..4828110	+	312	WP_000558166.1	type II toxin-antitoxin system HigB family toxin	-
L1L24_RS23690 (4828107)	4828107..4828553	+	447	WP_001259011.1	type II toxin-antitoxin system HigA family antitoxin	-
L1L24_RS23695 (4828568)	4828568..4829509	-	942	WP_001518251.1	fatty acid biosynthesis protein FabY	-
L1L24_RS23700 (4829554)	4829554..4829991	-	438	WP_000560973.1	D-aminoacyl-tRNA deacylase	-
L1L24_RS23705 (4829988)	4829988..4830860	-	873	WP_000921423.1	virulence factor BrkB family protein	-
L1L24_RS23710 (4830854)	4830854..4831453	-	600	WP_000965695.1	glucose-1-phosphatase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (36-85)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 12342.27 Da
• Isoelectric Point: 9.4460

>T232162 WP_001159632.1 NZ_CP090929:c4826566-4826255 [Salmonella enterica subsp. enterica serovar Agona]
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGSRGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Nucleotide

• Length: 312 bp

>T232162 NZ_CP127273:c2208814-2208395 [Mycobacterium tuberculosis]
ATGATCGTGGACACAAGCGCCGTGGTGGCCCTGGTTCAAGGCGAGCGGCCGCACGCCACCCTGGTCGCGGCCGCCCTGGC
CGGCGCCCATAGCCCCGTCATGTCTGCACCCACCGTCGCCGAATGCCTGATTGTCTTGACCGCCCGTCACGGCCCCGTTG
CGCGCACGATCTTCGAACGACTTCGCAGCGAAATCGGCTTGAGCGTGTCATCTTTCACCGCCGAGCATGCCGCTGCCACG
CAACGAGCCTTTCTGCGATACGGCAAGGGGCGCCACCGCGCGGCTCTCAACTTCGGAGACTGTATGACGTACGCGACCGC
CCAGCTGGGCCACCAACCACTGCTGGCCGTCGGCAACGACTTCCCGCAAACCGACCTTGAGTTCCGCGGCGTCGTCGGCT
ACTGGCCAGGCGTCGCGTAA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10957.57 Da
• Isoelectric Point: 10.6525

>AT232162 WP_000362051.1 NZ_CP090929:c4826254-4825964 [Salmonella enterica subsp. enterica serovar Agona]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKVKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Nucleotide

• Length: 291 bp

>AT232162 NZ_CP127273:c2209083-2208823 [Mycobacterium tuberculosis]
GTGGCGCTGAATATCAAAGACCCTGAGGTAGACCGACTAGCCGCCGAACTCGCTGACCGGCTGCACACCAGCAAGACTGC
CGCCATCCGGCATGCCCTGTCTGCCCAGCTGGCGTTTTTGGAGTCGCGCGCCGGCGACCGTGAGGCACAACTTCTCGACA
TCTTGCGTACCGAAATCTGGCCCCTGCTTGCCGACCGCTCCCCCATCACCAAGCTCGAGCGCGAACAAATCCTCGGCTAC
GACCCCGCAACCGGAGTCTGA

Structures

Toxin

• AlphaFold DB: A0A4U7VQ31