Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 2343286..2343788 Replicon chromosome
Accession NC_011415
Organism Escherichia coli SE11

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag ECSE_RS11910 Protein ID WP_000767829.1
Coordinates 2343286..2343540 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag ECSE_RS11915 Protein ID WP_001259255.1
Coordinates 2343537..2343788 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ECSE_RS11885 2338301..2338528 - 228 WP_000985273.1 sulfurtransferase TusA family protein -
ECSE_RS11890 2338542..2339600 - 1059 WP_000492345.1 transport protein YeeE -
ECSE_RS11895 2339779..2341137 - 1359 WP_000019197.1 putrescine/proton symporter PlaP -
ECSE_RS28420 2341127..2341189 - 63 WP_010723108.1 membrane protein YoeI -
ECSE_RS11900 2341404..2342333 - 930 WP_000803351.1 LysR family transcriptional regulator -
ECSE_RS11905 2342379..2343203 - 825 WP_000754758.1 SDR family oxidoreductase -
ECSE_RS11910 2343286..2343540 - 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
ECSE_RS11915 2343537..2343788 - 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
ECSE_RS27085 2344072..2344122 + 51 WP_001364200.1 his operon leader peptide -
ECSE_RS11920 2344268..2345167 + 900 WP_000131782.1 ATP phosphoribosyltransferase -
ECSE_RS11925 2345173..2346477 + 1305 WP_001317939.1 histidinol dehydrogenase -
ECSE_RS11930 2346474..2347544 + 1071 WP_000108941.1 histidinol-phosphate transaminase -
ECSE_RS11935 2347544..2348611 + 1068 WP_000080060.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T23215 WP_000767829.1 NC_011415:c2343540-2343286 [Escherichia coli SE11]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

>T23215 NC_011415:c2343540-2343286 [Escherichia coli SE11]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT23215 WP_001259255.1 NC_011415:c2343788-2343537 [Escherichia coli SE11]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp

>AT23215 NC_011415:c2343788-2343537 [Escherichia coli SE11]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATATAACTCCCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATCATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References