Detailed information of TA system TA232134

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 20619..21141
• Replicon: plasmid pSE45A5-1
• Accession: NZ_CP090916
• Organism: Staphylococcus epidermidis strain 45A5

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: KB229_RS12140
• Protein ID: WP_162154203.1
• Coordinates: 20866..21141 (+)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: KB229_RS12135
• Protein ID: WP_162154204.1
• Coordinates: 20619..20873 (+)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KB229_RS12105 (KB229_12105)	15726..15821	+	96	WP_002498742.1	type I toxin-antitoxin system Fst family toxin	-
KB229_RS12110 (KB229_12110)	15958..16821	-	864	WP_234966654.1	RepB family plasmid replication initiator protein	-
KB229_RS12115 (KB229_12115)	18132..18697	-	566	Protein_18	signal peptidase I	-
KB229_RS12120 (KB229_12120)	18875..18979	-	105	Protein_19	replication protein Rep	-
KB229_RS12125 (KB229_12125)	19040..19714	-	675	WP_234966623.1	IS6 family transposase	-
KB229_RS12130 (KB229_12130)	19768..19890	+	123	Protein_21	IS6 family transposase	-
KB229_RS12135 (KB229_12135)	20619..20873	+	255	WP_162154204.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
KB229_RS12140 (KB229_12140)	20866..21141	+	276	WP_162154203.1	Txe/YoeB family addiction module toxin	Toxin
KB229_RS12145 (KB229_12145)	21921..22199	-	279	WP_228449108.1	serine/threonine-protein kinase 10	-
KB229_RS12150 (KB229_12150)	23127..23282	-	156	WP_002494758.1	beta-class phenol-soluble modulin	-
KB229_RS12155 (KB229_12155)	23699..24560	+	862	Protein_26	RepB family plasmid replication initiator protein	-
KB229_RS12160 (KB229_12160)	24884..25314	+	431	Protein_27	IS3 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..53974	53974
	-	flank	IS/Tn	-	-	19040..19714	674
	-	flank	IS/Tn	-	-	24884..25189	305

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (9-89)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10811.43 Da
• Isoelectric Point: 9.9982

>T232134 WP_162154203.1 NZ_CP090916:20866-21141 [Staphylococcus epidermidis]
MSKRLNILFSPVAFDDYKHWQTQDKKLLKKINSLIKSIERDGLLEGEGKPEALRGNLKGYFSRRINHEHRLVYKINDASI
QIVSCRYHYYD

Nucleotide

• Length: 276 bp

>T232134 NZ_CP127273:c639949-639536 [Mycobacterium tuberculosis]
GTGAGAGCATCGCCCACTTCGCCGCCGGAGCAGGTGGTCGTCGACGCGAGTGCCATGGTGGATCTACTGGCTCGCACTAG
CGATCGGTGCTCTGCGGTGCGCGCGCGGCTGGCTCGGACCGCGATGCACGCGCCGGCGCACTTCGATGCAGAGGTGTTGT
CGGCGCTGGGGCGCATGCAGCGCGCCGGCGCACTCACCGTTGCCTATGTCGATGCGGCACTGGAGGAGTTGCGACAGGTG
CCGGTGACTCGACACGGTCTTTCGTCGCTGCTTGCTGGAGCGTGGTCGCGCCGCGACACCCTCCGCCTGACCGATGCCCT
CTACGTCGAGCTGGCCGAAACGGCAGGTCTGGTGTTGTTGACCACCGACGAAAGATTGGCACGCGCCTGGCCCTCGGCTC
ACGCCATCGGCTGA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9548.46 Da
• Isoelectric Point: 4.2529

>AT232134 WP_162154204.1 NZ_CP090916:20619-20873 [Staphylococcus epidermidis]
MTVVTYSNARKDFRNLIDKVNNDSDSVTITTNNHNAVLLSENDYNAIMETLYLQQSPSNARHLAKSIDDLERGNIIEVDI
DSYE

Nucleotide

• Length: 255 bp

>AT232134 NZ_CP127273:c640212-639946 [Mycobacterium tuberculosis]
TTGTTGAGCCGGCGCACGAAAACGATCGTTGTGTGTACATTGGTGTGTATGGCTCGGTTGAACGTGTATGTGCCCGACGA
ATTGGCGGAGCGCGCCAGGGCGCGGGGCTTGAACGTCTCGGCGCTGACTCAGGCCGCGATCAGTGCCGAGTTGGAGAACT
CCGCAACCGATGCGTGGCTTGAGGGGTTGGAACCCAGAAGCACCGGCGCTCGGCATGATGACGTGCTGGGTGCGATCGAT
GCCGCTCGCGATGAGTTCGAAGCGTGA