Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2761187..2761941 Replicon chromosome
Accession NZ_CP090909
Organism Enterobacter hormaechei strain M1

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag L1E13_RS13095 Protein ID WP_234978747.1
Coordinates 2761187..2761501 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag L1E13_RS13100 Protein ID WP_127350064.1
Coordinates 2761498..2761941 (+) Length 148 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L1E13_RS13075 (L1E13_13075) 2756853..2757938 + 1086 Protein_2553 cellulase family glycosylhydrolase -
L1E13_RS13080 (L1E13_13080) 2757844..2759028 - 1185 WP_003861070.1 multidrug efflux MFS transporter EmrD -
L1E13_RS13085 (L1E13_13085) 2759204..2760037 - 834 WP_023323922.1 DMT family transporter -
L1E13_RS13090 (L1E13_13090) 2760100..2760546 - 447 WP_003861064.1 GNAT family N-acetyltransferase -
L1E13_RS13095 (L1E13_13095) 2761187..2761501 + 315 WP_234978747.1 type II toxin-antitoxin system HigB family toxin Toxin
L1E13_RS13100 (L1E13_13100) 2761498..2761941 + 444 WP_127350064.1 helix-turn-helix domain-containing protein Antitoxin
L1E13_RS13105 (L1E13_13105) 2762042..2762140 + 99 WP_057979964.1 ilvB operon leader peptide IvbL -
L1E13_RS13110 (L1E13_13110) 2762247..2763935 + 1689 WP_003861056.1 acetolactate synthase large subunit -
L1E13_RS13115 (L1E13_13115) 2763939..2764226 + 288 WP_003861055.1 acetolactate synthase small subunit -
L1E13_RS13120 (L1E13_13120) 2764309..2764902 + 594 WP_003861054.1 transcriptional regulator UhpA -
L1E13_RS13125 (L1E13_13125) 2764899..2766404 + 1506 WP_032608151.1 signal transduction histidine-protein kinase/phosphatase UhpB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2760611..2774165 13554


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(21-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(84-136)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 12445.54 Da        Isoelectric Point: 10.2825

>T232118 WP_234978747.1 NZ_CP090909:2761187-2761501 [Enterobacter hormaechei]
MHLISMKAILDAVSQFPQHREELLFLGRVIEKSHCPTPATLRKLFPTLDNFKYLDKHYVIDIANNNLRVVALIFFESQKF
YVRHVFTHKEYDRFTEKHRTKGKK

Download         Length: 315 bp

>T232118 NZ_CP127255:c3844847-3844593 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACACCATTTGAAGGTAAGGGGAAACCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACTGATGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 148 a.a.        Molecular weight: 16447.12 Da        Isoelectric Point: 5.6250

>AT232118 WP_127350064.1 NZ_CP090909:2761498-2761941 [Enterobacter hormaechei]
MMIVADAMKATHALVAAVPLLGEQPSEKDYKDALELVEYLLMNEPNSPLLDIVCARISRYEANRPEIVALRKEMESVPVG
IAVLRTLMDQYNLTISDFQDEIGSKSMVSRVLNGQRQLTLNHIKKLAVRFGVSPALFIECHHPTNET

Download         Length: 444 bp

>AT232118 NZ_CP127255:c3845095-3844844 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References