Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1624262..1624919 Replicon chromosome
Accession NZ_CP090909
Organism Enterobacter hormaechei strain M1

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag L1E13_RS07675 Protein ID WP_032609983.1
Coordinates 1624262..1624561 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag L1E13_RS07680 Protein ID WP_032609984.1
Coordinates 1624572..1624919 (+) Length 116 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L1E13_RS07665 (L1E13_07665) 1620639..1622831 + 2193 WP_234979326.1 type I secretion system permease/ATPase -
L1E13_RS07670 (L1E13_07670) 1622812..1624011 + 1200 WP_032609982.1 HlyD family efflux transporter periplasmic adaptor subunit -
L1E13_RS07675 (L1E13_07675) 1624262..1624561 + 300 WP_032609983.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
L1E13_RS07680 (L1E13_07680) 1624572..1624919 + 348 WP_032609984.1 HigA family addiction module antitoxin Antitoxin
L1E13_RS07685 (L1E13_07685) 1624995..1626176 - 1182 WP_023314694.1 PLP-dependent aminotransferase family protein -
L1E13_RS07690 (L1E13_07690) 1626197..1627084 - 888 WP_032660046.1 LysR family transcriptional regulator -
L1E13_RS07695 (L1E13_07695) 1627182..1627784 + 603 WP_048210584.1 short chain dehydrogenase -
L1E13_RS07700 (L1E13_07700) 1627781..1628512 - 732 WP_063944424.1 class I SAM-dependent methyltransferase -
L1E13_RS07705 (L1E13_07705) 1628587..1629585 - 999 WP_022651706.1 transketolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-95)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(6-103)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11610.24 Da        Isoelectric Point: 9.6776

>T232116 WP_032609983.1 NZ_CP090909:1624262-1624561 [Enterobacter hormaechei]
MINHFRDQWLEDFFLYGRSSNVIPLNLETALARKLDIINAAMSHLDLRSPPGNIYEALSPTLKGYSSIRVNRQYRLVFRW
SEGKADDLYLSPHKYTQHK

Download         Length: 300 bp

>T232116 NZ_CP127255:c3265359-3265090 [Escherichia coli]
ATGATAATGAATTTCAGACACAAGGGATTGCGTGACTTGTTTCTTCTCGGCAAAACCTCCGGCGTTATACCGACACGATT
ACGCCACCGACTCGCTGTGATTGATGCAGCATGCTGTCTTGCTGATATCGATATGCCCGGTTACCGACTACATCCGTTAA
GCGGCGATCGCGATGGAATTTGGGCGATATCTGTCTCGGGCAACTGGCGAATCACATTTGAATTCGTCAATGGCGATGCA
TACATACTGGATTACGAGGACTATCACTGA

Antitoxin


Download         Length: 116 a.a.        Molecular weight: 13094.06 Da        Isoelectric Point: 9.5932

>AT232116 WP_032609984.1 NZ_CP090909:1624572-1624919 [Enterobacter hormaechei]
MTLQQALRKPTTPGEVLQYEYLEPLNLKINDLAEVLNVHRNTVSALVNNNRKLTADMAIKLAKAFNTTIEFWLNLQLNVD
IWETQSNSRTQEELSRIKTVAEVMAKRKSGKPDVA

Download         Length: 348 bp

>AT232116 NZ_CP127255:c3265090-3264806 [Escherichia coli]
ATGAAAATGGCCAATCATCCCCGCCCGGGGGACATTATTCAGGAATCACTGGACGAACTTAATGTCAGCCTGCGCGAGTT
TGCCAGAGCAATGGAAATTGCGCCCTCAACGGCAAGCCGATTGCTGACCGGAAAAGCAGCTTTGACGCCAGAAATGGCAA
TAAAACTTTCCGTGGTGATCGGCAGTTCGCCGCAAATGTGGCTGAATCTGCAAAATGCCTGGAGTCTGGCAGAGGCAGAA
AAAACAGTGGATGTGTCGCGACTGCGCCGTCTGGTTACGCAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References