Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | higBA (relBE)/COG4683-HTH_37 |
Location | 4339516..4340168 | Replicon | chromosome |
Accession | NZ_CP090908 | ||
Organism | Serratia marcescens strain Sys06 |
Toxin (Protein)
Gene name | higB | Uniprot ID | A0A0P0QIF7 |
Locus tag | L1F17_RS21070 | Protein ID | WP_060560142.1 |
Coordinates | 4339516..4339860 (+) | Length | 115 a.a. |
Antitoxin (Protein)
Gene name | higA | Uniprot ID | A0A086GAN0 |
Locus tag | L1F17_RS21075 | Protein ID | WP_004931828.1 |
Coordinates | 4339866..4340168 (+) | Length | 101 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
L1F17_RS21060 (L1F17_21060) | 4335858..4338116 | - | 2259 | WP_060560141.1 | molybdopterin guanine dinucleotide-containing S/N-oxide reductase | - |
L1F17_RS21065 (L1F17_21065) | 4338337..4339356 | + | 1020 | WP_004931832.1 | HTH-type transcriptional regulator GalR | - |
L1F17_RS21070 (L1F17_21070) | 4339516..4339860 | + | 345 | WP_060560142.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
L1F17_RS21075 (L1F17_21075) | 4339866..4340168 | + | 303 | WP_004931828.1 | XRE family transcriptional regulator | Antitoxin |
L1F17_RS21080 (L1F17_21080) | 4340196..4341458 | - | 1263 | WP_060560144.1 | diaminopimelate decarboxylase | - |
L1F17_RS21085 (L1F17_21085) | 4341592..4342515 | + | 924 | WP_060560145.1 | LysR family transcriptional regulator | - |
L1F17_RS21090 (L1F17_21090) | 4342543..4343451 | - | 909 | WP_015378928.1 | LysR family transcriptional regulator | - |
L1F17_RS21095 (L1F17_21095) | 4343560..4344444 | + | 885 | WP_004931820.1 | MBL fold metallo-hydrolase | - |
L1F17_RS21100 (L1F17_21100) | 4344519..4345166 | + | 648 | WP_033632219.1 | DsbA family protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 115 a.a. Molecular weight: 13441.54 Da Isoelectric Point: 10.4277
>T232103 WP_060560142.1 NZ_CP090908:4339516-4339860 [Serratia marcescens]
MWQVVTVERFDDWFLALNNAQQTSILAAIYKLQTFGPQLARPHADTLHFSDAVRQLKELRIQYRGRPFRMFFAFDPQRQA
VLLCGGDKTGDKRFYQRMLPIAAMEFSHYLATRR
MWQVVTVERFDDWFLALNNAQQTSILAAIYKLQTFGPQLARPHADTLHFSDAVRQLKELRIQYRGRPFRMFFAFDPQRQA
VLLCGGDKTGDKRFYQRMLPIAAMEFSHYLATRR
Download Length: 345 bp
>T232103 NZ_CP127254:12656-12805 [Escherichia coli]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGCGCTACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAGCTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGCGCTACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAGCTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA
Antitoxin
Download Length: 101 a.a. Molecular weight: 11080.97 Da Isoelectric Point: 10.1998
>AT232103 WP_004931828.1 NZ_CP090908:4339866-4340168 [Serratia marcescens]
MAKPLSQLIDKLDPAVVAAARQKADQEIFELRLAMLREELAVSQVELAKRLGISQPSVANLEKRGSEIKLSSLKRYIEAM
GGTLSLDVQLPNGQHRRMTL
MAKPLSQLIDKLDPAVVAAARQKADQEIFELRLAMLREELAVSQVELAKRLGISQPSVANLEKRGSEIKLSSLKRYIEAM
GGTLSLDVQLPNGQHRRMTL
Download Length: 303 bp
>AT232103 NZ_CP127254:c12612-12551 [Escherichia coli]
TTAAGGTACTTCATGCAGACCTCACGAGTTAATGGATTAACAAGTGGGGTCTTCGCATTTCT
TTAAGGTACTTCATGCAGACCTCACGAGTTAATGGATTAACAAGTGGGGTCTTCGCATTTCT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0P0QIF7 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A086GAN0 |