Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 4339516..4340168 Replicon chromosome
Accession NZ_CP090908
Organism Serratia marcescens strain Sys06

Toxin (Protein)


Gene name higB Uniprot ID A0A0P0QIF7
Locus tag L1F17_RS21070 Protein ID WP_060560142.1
Coordinates 4339516..4339860 (+) Length 115 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A086GAN0
Locus tag L1F17_RS21075 Protein ID WP_004931828.1
Coordinates 4339866..4340168 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L1F17_RS21060 (L1F17_21060) 4335858..4338116 - 2259 WP_060560141.1 molybdopterin guanine dinucleotide-containing S/N-oxide reductase -
L1F17_RS21065 (L1F17_21065) 4338337..4339356 + 1020 WP_004931832.1 HTH-type transcriptional regulator GalR -
L1F17_RS21070 (L1F17_21070) 4339516..4339860 + 345 WP_060560142.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
L1F17_RS21075 (L1F17_21075) 4339866..4340168 + 303 WP_004931828.1 XRE family transcriptional regulator Antitoxin
L1F17_RS21080 (L1F17_21080) 4340196..4341458 - 1263 WP_060560144.1 diaminopimelate decarboxylase -
L1F17_RS21085 (L1F17_21085) 4341592..4342515 + 924 WP_060560145.1 LysR family transcriptional regulator -
L1F17_RS21090 (L1F17_21090) 4342543..4343451 - 909 WP_015378928.1 LysR family transcriptional regulator -
L1F17_RS21095 (L1F17_21095) 4343560..4344444 + 885 WP_004931820.1 MBL fold metallo-hydrolase -
L1F17_RS21100 (L1F17_21100) 4344519..4345166 + 648 WP_033632219.1 DsbA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-104)

Antitoxin

Cro/C1-type helix-turn-helix domain

(32-85)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 13441.54 Da        Isoelectric Point: 10.4277

>T232103 WP_060560142.1 NZ_CP090908:4339516-4339860 [Serratia marcescens]
MWQVVTVERFDDWFLALNNAQQTSILAAIYKLQTFGPQLARPHADTLHFSDAVRQLKELRIQYRGRPFRMFFAFDPQRQA
VLLCGGDKTGDKRFYQRMLPIAAMEFSHYLATRR

Download         Length: 345 bp

>T232103 NZ_CP127254:12656-12805 [Escherichia coli]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGCGCTACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAGCTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11080.97 Da        Isoelectric Point: 10.1998

>AT232103 WP_004931828.1 NZ_CP090908:4339866-4340168 [Serratia marcescens]
MAKPLSQLIDKLDPAVVAAARQKADQEIFELRLAMLREELAVSQVELAKRLGISQPSVANLEKRGSEIKLSSLKRYIEAM
GGTLSLDVQLPNGQHRRMTL

Download         Length: 303 bp

>AT232103 NZ_CP127254:c12612-12551 [Escherichia coli]
TTAAGGTACTTCATGCAGACCTCACGAGTTAATGGATTAACAAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0P0QIF7

Antitoxin

Source ID Structure
AlphaFold DB A0A086GAN0

References