Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 3511102..3511762 Replicon chromosome
Accession NZ_CP090908
Organism Serratia marcescens strain Sys06

Toxin (Protein)


Gene name higB Uniprot ID A0A0P0QGN5
Locus tag L1F17_RS16955 Protein ID WP_060559891.1
Coordinates 3511409..3511762 (-) Length 118 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A2V4GQ69
Locus tag L1F17_RS16950 Protein ID WP_033635213.1
Coordinates 3511102..3511404 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L1F17_RS16930 (L1F17_16930) 3506729..3507643 - 915 WP_048324303.1 branched-chain amino acid ABC transporter permease -
L1F17_RS16935 (L1F17_16935) 3507767..3508885 - 1119 WP_033632602.1 branched-chain amino acid ABC transporter substrate-binding protein -
L1F17_RS16945 (L1F17_16945) 3509468..3510676 - 1209 WP_033632601.1 aldose 1-epimerase family protein -
L1F17_RS16950 (L1F17_16950) 3511102..3511404 - 303 WP_033635213.1 XRE family transcriptional regulator Antitoxin
L1F17_RS16955 (L1F17_16955) 3511409..3511762 - 354 WP_060559891.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
L1F17_RS16960 (L1F17_16960) 3512200..3513495 + 1296 WP_033632599.1 MFS transporter -
L1F17_RS16965 (L1F17_16965) 3513522..3514328 + 807 WP_060559892.1 substrate-binding domain-containing protein -
L1F17_RS16970 (L1F17_16970) 3514303..3515202 - 900 WP_049278342.1 LysR family transcriptional regulator -
L1F17_RS16975 (L1F17_16975) 3515306..3515791 - 486 WP_228392530.1 diacylglycerol kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-106)

Antitoxin

HigA2-like, helix-turn-helix domain

(12-89)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13508.46 Da        Isoelectric Point: 9.5163

>T232101 WP_060559891.1 NZ_CP090908:c3511762-3511409 [Serratia marcescens]
VWEIKTTDAFDHWFRSLSDADRACVLAALMVLRGKGPGLPRPYADTVKGSRYSNMKELRIQSRGEPLRAFFAFDPYRIGM
VLCAGNKAGNEKRFYDRMVQIADREFTNWLNTLNEKE

Download         Length: 354 bp

>T232101 NZ_CP127252:4887070-4887534 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTTTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAAGCCTCACCCAAGAGACAGAAGAAAACCATTGA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11079.94 Da        Isoelectric Point: 6.4738

>AT232101 WP_033635213.1 NZ_CP090908:c3511404-3511102 [Serratia marcescens]
MGRTLEQLIADEKPEVVAKAQALAADIMLNIHLAELREKVQKTQVEMAQALGIRQPTVAVMEKPGRDLKLSSLKRYVEAA
GGKLRLDVELPDGSHYEFVL

Download         Length: 303 bp

>AT232101 NZ_CP127252:4886735-4887070 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTCTTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0P0QGN5

Antitoxin

Source ID Structure
AlphaFold DB A0A2V4GQ69

References