Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | higBA (relBE)/COG4683-HTH_37 |
Location | 3511102..3511762 | Replicon | chromosome |
Accession | NZ_CP090908 | ||
Organism | Serratia marcescens strain Sys06 |
Toxin (Protein)
Gene name | higB | Uniprot ID | A0A0P0QGN5 |
Locus tag | L1F17_RS16955 | Protein ID | WP_060559891.1 |
Coordinates | 3511409..3511762 (-) | Length | 118 a.a. |
Antitoxin (Protein)
Gene name | higA | Uniprot ID | A0A2V4GQ69 |
Locus tag | L1F17_RS16950 | Protein ID | WP_033635213.1 |
Coordinates | 3511102..3511404 (-) | Length | 101 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
L1F17_RS16930 (L1F17_16930) | 3506729..3507643 | - | 915 | WP_048324303.1 | branched-chain amino acid ABC transporter permease | - |
L1F17_RS16935 (L1F17_16935) | 3507767..3508885 | - | 1119 | WP_033632602.1 | branched-chain amino acid ABC transporter substrate-binding protein | - |
L1F17_RS16945 (L1F17_16945) | 3509468..3510676 | - | 1209 | WP_033632601.1 | aldose 1-epimerase family protein | - |
L1F17_RS16950 (L1F17_16950) | 3511102..3511404 | - | 303 | WP_033635213.1 | XRE family transcriptional regulator | Antitoxin |
L1F17_RS16955 (L1F17_16955) | 3511409..3511762 | - | 354 | WP_060559891.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
L1F17_RS16960 (L1F17_16960) | 3512200..3513495 | + | 1296 | WP_033632599.1 | MFS transporter | - |
L1F17_RS16965 (L1F17_16965) | 3513522..3514328 | + | 807 | WP_060559892.1 | substrate-binding domain-containing protein | - |
L1F17_RS16970 (L1F17_16970) | 3514303..3515202 | - | 900 | WP_049278342.1 | LysR family transcriptional regulator | - |
L1F17_RS16975 (L1F17_16975) | 3515306..3515791 | - | 486 | WP_228392530.1 | diacylglycerol kinase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 118 a.a. Molecular weight: 13508.46 Da Isoelectric Point: 9.5163
>T232101 WP_060559891.1 NZ_CP090908:c3511762-3511409 [Serratia marcescens]
VWEIKTTDAFDHWFRSLSDADRACVLAALMVLRGKGPGLPRPYADTVKGSRYSNMKELRIQSRGEPLRAFFAFDPYRIGM
VLCAGNKAGNEKRFYDRMVQIADREFTNWLNTLNEKE
VWEIKTTDAFDHWFRSLSDADRACVLAALMVLRGKGPGLPRPYADTVKGSRYSNMKELRIQSRGEPLRAFFAFDPYRIGM
VLCAGNKAGNEKRFYDRMVQIADREFTNWLNTLNEKE
Download Length: 354 bp
>T232101 NZ_CP127252:4887070-4887534 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTTTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAAGCCTCACCCAAGAGACAGAAGAAAACCATTGA
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTTTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAAGCCTCACCCAAGAGACAGAAGAAAACCATTGA
Antitoxin
Download Length: 101 a.a. Molecular weight: 11079.94 Da Isoelectric Point: 6.4738
>AT232101 WP_033635213.1 NZ_CP090908:c3511404-3511102 [Serratia marcescens]
MGRTLEQLIADEKPEVVAKAQALAADIMLNIHLAELREKVQKTQVEMAQALGIRQPTVAVMEKPGRDLKLSSLKRYVEAA
GGKLRLDVELPDGSHYEFVL
MGRTLEQLIADEKPEVVAKAQALAADIMLNIHLAELREKVQKTQVEMAQALGIRQPTVAVMEKPGRDLKLSSLKRYVEAA
GGKLRLDVELPDGSHYEFVL
Download Length: 303 bp
>AT232101 NZ_CP127252:4886735-4887070 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTCTTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTCTTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0P0QGN5 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A2V4GQ69 |