Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 631133..631659 Replicon chromosome
Accession NZ_CP090898
Organism Synechococcus sp. NB0720_010

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag LY254_RS03385 Protein ID WP_247479719.1
Coordinates 631133..631357 (+) Length 75 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LY254_RS03390 Protein ID WP_010317730.1
Coordinates 631357..631659 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LY254_RS03365 (LY254_03365) 626808..628169 + 1362 WP_247478917.1 glutathione-disulfide reductase -
LY254_RS03370 (LY254_03370) 628174..628881 + 708 WP_247478918.1 SDR family NAD(P)-dependent oxidoreductase -
LY254_RS03375 (LY254_03375) 628878..630209 - 1332 WP_247478920.1 sodium:alanine symporter family protein -
LY254_RS03380 (LY254_03380) 630259..630936 - 678 WP_247478921.1 DUF3386 domain-containing protein -
LY254_RS03385 (LY254_03385) 631133..631357 + 225 WP_247479719.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LY254_RS03390 (LY254_03390) 631357..631659 + 303 WP_010317730.1 HigA family addiction module antitoxin Antitoxin
LY254_RS03395 (LY254_03395) 631664..634957 - 3294 WP_247478922.1 carbamoyl-phosphate synthase large subunit -
LY254_RS03400 (LY254_03400) 635083..635718 + 636 WP_010317727.1 DUF3318 domain-containing protein -
LY254_RS03405 (LY254_03405) 635711..636139 + 429 WP_247478923.1 ribosome silencing factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-74)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(7-84)


Sequences

Toxin        


Download         Length: 75 a.a.        Molecular weight: 8672.84 Da        Isoelectric Point: 8.0528

>T232077 WP_247479719.1 NZ_CP090898:631133-631357 [Synechococcus sp. NB0720_010]
IPRFQAFERVARRKLRQLDIASRLEDLRIPPGNRLEALRGDRAGEHSIRINDQFRLCFVWSDSGPEAVEIVDYH

Download         Length: 225 bp

>T232077 NZ_CP127244:c241187-241005 [Salinicola sp. JS01]
GTGGATAGCAGGGCCCTCATTCGGGAGCTTGAGCGTGATGGCTGGGCGCTAGTCAGAGTCAACGGCAGCCACCACCACTT
CAGGCACCCTATCAAGCCCGGCACGGTCACGGTGCCCCACCCCAAGAAGGATCTGAAAACGGGGCTGGTCAAAGGCATCA
GGAAAAGCGCAGGCCTCGACTGA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 10869.54 Da        Isoelectric Point: 5.8146

>AT232077 WP_010317730.1 NZ_CP090898:631357-631659 [Synechococcus sp. NB0720_010]
MTATHRLSPITPGELLVEEFLVPLGVSQYRLSKAIKVPASRISEIVSGQRSISADTDLRLCRFLGLSPGYWLRAQAAYDT
EIAGAELAEEIAKIQPLVSS

Download         Length: 303 bp

>AT232077 NZ_CP127244:c240984-240565 [Salinicola sp. JS01]
ATGTTGTTTCCCATTGCCATCGAGCGCGGCGACGCACAGCACGCCTACGGTGTCGCCGTTCCCGACCTGCCTGGCTGCTT
CTCGGCGGGTGACACCCTCGAGGAAGCCCTGGCCAACGTGCATGAAGCCATCGCCGGGTGGCTCGAGACGGCGGTCGACG
TCGGCGACCCGATTCCGCAGGCGACGAGTCTCGAGCACCACCTCGACAACCCGGACTTCGCCGGCTGGATCTGGGCCGTG
GTCGATATCGACGTGACGCCCTACCTGGGCAAGAGCCACAAGATCAACGTCACCCTGCCCGACCTGCTGGTCAAACGCAT
CGACGAATTCGTCGCCACCCACGATGGCGACAAGACCCGTTCCGGCTTCCTCGCCCGCATCGCCCTACAGGAACTGACCA
GAGCCCGTAAGGACGTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References