Detailed information of TA system TA232038

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprA1-sprA1AS/-
• Location: 2072396..2072576
• Replicon: chromosome
• Accession: NZ_CP090879
• Organism: Staphylococcus aureus strain SAUR_BFS2

Toxin (Protein)

• Gene name: sprA1
• Uniprot ID: -
• Locus tag: L1A04_RS10450
• Protein ID: WP_001801861.1
• Coordinates: 2072481..2072576 (-)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	2072396..2072453 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L1A04_RS10425	2067809..2070229	-	2421	WP_033844720.1	polysaccharide lyase 8 family protein	-
L1A04_RS10430	2070754..2071196	+	443	Protein_2011	DUF1433 domain-containing protein	-
L1A04_RS10435	2071196..2071639	+	444	WP_000731421.1	DUF1433 domain-containing protein	-
L1A04_RS10440	2071639..2072082	+	444	WP_234877952.1	DUF1433 domain-containing protein	-
L1A04_RS10445	2072257..2072358	-	102	WP_001791232.1	hypothetical protein	-
-	2072396..2072453	+	58	-	-	Antitoxin
L1A04_RS10450	2072481..2072576	-	96	WP_001801861.1	type I toxin-antitoxin system Fst family toxin PepA1	Toxin
L1A04_RS10455	2073027..2073473	+	447	WP_000747804.1	DUF1433 domain-containing protein	-
L1A04_RS10460	2073666..2074235	+	570	WP_000125075.1	ImmA/IrrE family metallo-endopeptidase	-
L1A04_RS10465	2074235..2075602	+	1368	WP_001093574.1	FRG domain-containing protein	-
L1A04_RS10470	2075751..2076323	-	573	WP_000414222.1	hypothetical protein	-
L1A04_RS10475	2076421..2076765	-	345	WP_000627550.1	DUF3969 family protein	-
L1A04_RS10480	2076806..2077432	-	627	WP_000669038.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	selk / hysA	2042597..2079198	36601

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-114)

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3554.32 Da
• Isoelectric Point: 10.4449

>T232038 WP_001801861.1 NZ_CP090879:c2072576-2072481 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Nucleotide

• Length: 96 bp

>T232038 NZ_CP127228:c4179265-4178885 [Pseudomonas tohonis]
ATGAGCGTTCTCGTCGACACCTCGGTCTGGATCGACCACTTCCGCAATGGCAACGAAGAACTGGTGCGATTGATCGGGCA
AGATCAGGTGCTGGTCCATCCCTTGGTCATCGGGGAGATCGCCTGCGGCACACCTCCGGCGCCAAGGGCAGAAACGCTGC
GCAACCTGTCCCTGCTACTGCCCTGCACCCAGGCAACCCTTGCCGAAGTGATGGCATTCATCGAACGGGAGCAGCTCTAC
GGCCTCGGCTGTGGATGGGTGGACCTCACGCTGCTGGCCTCCACCCTGATGACACCCGGCGCCAGACTCTGGACGCTCGA
CAGGCGCCTCGCCCAACTGGCCGGGCGTTTCGGCGTGGCACACCACCCGTCGCGGCATTGA

Antitoxin

Nucleotide

• Length: 58 bp

>AT232038 NZ_CP090879:2072396-2072453 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin