Detailed information of TA system TA232034

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 1916801..1917139
• Replicon: chromosome
• Accession: NZ_CP090879
• Organism: Staphylococcus aureus strain SAUR_BFS2

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: L1A04_RS09475
• Protein ID: WP_011447039.1
• Coordinates: 1916801..1916977 (+)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	1916965..1917139 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L1A04_RS09455	1912036..1915821	+	3786	WP_000582165.1	phage tail spike protein	-
L1A04_RS09460	1915811..1915963	+	153	WP_001153681.1	hypothetical protein	-
L1A04_RS09465	1916010..1916297	+	288	WP_001040261.1	hypothetical protein	-
L1A04_RS09470	1916355..1916651	+	297	WP_000539688.1	DUF2951 domain-containing protein	-
L1A04_RS09475	1916801..1916977	+	177	WP_011447039.1	type I toxin-antitoxin system toxin PepG1	Toxin
-	1916965..1917139	-	175	-	-	Antitoxin
L1A04_RS09485	1917189..1917443	+	255	WP_000611512.1	phage holin	-
L1A04_RS09490	1917455..1918210	+	756	WP_060474098.1	CHAP domain-containing protein	-
L1A04_RS09495	1918402..1918893	+	492	WP_000919350.1	staphylokinase	-
L1A04_RS09500	1919543..1919878	+	336	Protein_1862	SH3 domain-containing protein	-
L1A04_RS09505	1919973..1920422	-	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
L1A04_RS09510	1921107..1921457	+	351	WP_000702263.1	complement inhibitor SCIN-A	-
L1A04_RS09515	1921510..1921770	-	261	WP_001791826.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	groEL / hlb / sak / chp / scn	1876026..1921457	45431

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T232034 WP_011447039.1 NZ_CP090879:1916801-1916977 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T232034 NZ_CP127225:c4484799-4484647 [Xanthomonas oryzae pv. oryzae]
ATGAAGCGACTGCTGACACTGATGGTGCTGGGCCTGTTTTCGGCCGGCGTGATGACGGGCTGCAACACCGTGGCTGGCGC
TGGCAAGGACTTGCAGGGCGCGGGTGGGAAGGTCGAGAAAACGGCCGAAAAATGCAGCGATGGTAAGTGCTGA

Antitoxin

Nucleotide

• Length: 175 bp

>AT232034 NZ_CP090879:c1917139-1916965 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Structures

Toxin

• PDB: 7NS1

Antitoxin