Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 1491854..1492371 Replicon chromosome
Accession NZ_CP090879
Organism Staphylococcus aureus strain SAUR_BFS2

Toxin (Protein)


Gene name yoeB Uniprot ID A0A170NWK0
Locus tag L1A04_RS07230 Protein ID WP_000251928.1
Coordinates 1492105..1492371 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A166LMC5
Locus tag L1A04_RS07225 Protein ID WP_000584497.1
Coordinates 1491854..1492105 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L1A04_RS07195 (1487554) 1487554..1488273 + 720 WP_000479573.1 amino acid ABC transporter permease -
L1A04_RS07200 (1488270) 1488270..1489001 + 732 WP_000615467.1 amino acid ABC transporter ATP-binding protein -
L1A04_RS07205 (1489098) 1489098..1490348 - 1251 WP_001012237.1 FemA/FemB family glycyltransferase FmhA -
L1A04_RS07210 (1490603) 1490603..1490965 + 363 WP_000819843.1 DUF4467 domain-containing protein -
L1A04_RS07215 (1490984) 1490984..1491583 + 600 WP_000162804.1 DsbA family protein -
L1A04_RS07220 (1491590) 1491590..1491690 + 101 Protein_1420 hypothetical protein -
L1A04_RS07225 (1491854) 1491854..1492105 + 252 WP_000584497.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
L1A04_RS07230 (1492105) 1492105..1492371 + 267 WP_000251928.1 Txe/YoeB family addiction module toxin Toxin
L1A04_RS07235 (1492664) 1492664..1494211 + 1548 WP_000727771.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
L1A04_RS07240 (1494397) 1494397..1494864 + 468 WP_000153340.1 SRPBCC domain-containing protein -
L1A04_RS07245 (1494951) 1494951..1495133 + 183 WP_000079140.1 hypothetical protein -
L1A04_RS07250 (1495336) 1495336..1496160 + 825 WP_000594640.1 formate/nitrite transporter family protein -
L1A04_RS07255 (1496628) 1496628..1497164 + 537 WP_000024292.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10465.06 Da        Isoelectric Point: 10.1628

>T232027 WP_000251928.1 NZ_CP090879:1492105-1492371 [Staphylococcus aureus]
MVRLNITFSPQAFEDYKYFQQNDKKMVKKINELIKSIDRNGALKGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T232027 NZ_CP127177:2634734-2634877 [Enterococcus faecalis]
ATGAATGTAAGTACTAAAATCTATGAAAGGAGAGGCCTTTTGTCTATCGCAGAAGCTTTAGCTCTGATGATTAGTTTCGG
TTCTTTTATCGCAACGTTAATCTTCGGAATCCTAGAGGCTGTAAAAGAAAACAATAAAAAATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9401.54 Da        Isoelectric Point: 4.3407

>AT232027 WP_000584497.1 NZ_CP090879:1491854-1492105 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDIVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTVTKD
IDV

Download         Length: 252 bp

>AT232027 NZ_CP127177:c2635071-2634809 [Enterococcus faecalis]
AAATAAAAATGCCCGAGCCTCTTATTTTTCTAAGGCTCGGGCATTTTTATTGATGGTCTTTTGAGGGTCGTTGTGCTATA
ATGGTAATGAAAAGAGAGGTATGCGACAACATACCTCTCTAGTGTAGAGCCGTTTCAGACGGTAGCGATTTTTAGTGATT
TATAAAAAATAACCGTGCTCGCTAAAGTTGACGGTTATTTTTTATTGTTTTCTTTTACAGCCTCTAGGATTCCGAAGATT
AACGTTGCGATAAAAGAACCGAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A170NWK0

Antitoxin

Source ID Structure
AlphaFold DB A0A166LMC5

References