Detailed information of TA system TA232025

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 1466887..1467071
• Replicon: chromosome
• Accession: NZ_CP090879
• Organism: Staphylococcus aureus strain SAUR_BFS2

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: -
• Locus tag: L1A04_RS07095
• Protein ID: WP_057485587.1
• Coordinates: 1466887..1466994 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	1467011..1467071 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L1A04_RS07070	1462249..1462722	+	474	WP_000456496.1	GyrI-like domain-containing protein	-
L1A04_RS07075	1462845..1464056	-	1212	WP_001191919.1	multidrug effflux MFS transporter	-
L1A04_RS07080	1464238..1464897	-	660	WP_000831298.1	membrane protein	-
L1A04_RS07085	1464957..1466099	-	1143	WP_001176855.1	glycerate kinase	-
L1A04_RS07090	1466367..1466753	+	387	WP_000779351.1	flippase GtxA	-
L1A04_RS07095	1466887..1466994	+	108	WP_057485587.1	type I toxin-antitoxin system Fst family toxin	Toxin
-	1467011..1467071	-	61	-	-	Antitoxin
L1A04_RS07100	1467642..1469405	+	1764	WP_033844405.1	ABC transporter ATP-binding protein	-
L1A04_RS07105	1469430..1471163	+	1734	WP_000486505.1	ABC transporter ATP-binding protein	-
L1A04_RS07110	1471394..1471561	+	168	Protein_1398	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (10-112)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4070.80 Da
• Isoelectric Point: 9.4175

>T232025 WP_057485587.1 NZ_CP090879:1466887-1466994 [Staphylococcus aureus]
MFNLLIDIMTSALSDCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T232025 NZ_CP127177:c2628633-2628292 [Enterococcus faecalis]
ATGAATGTTGAAAAGAAGTACATTCCCAAAAAAGGAGATATTGTATGGATTGATTTTGATCCTGCTGCAGGCAAAGAGAT
TCAGAAGAGACGGCCTGGTTTAGTCGTGTCAAGATATGAATTTAATCGGAAAACCATGTTTGCTGTGATTTGCCCGATTA
CTTCCACCATTAAAAATATTCCCACTCGATATACGTTGCCCGATGACATAGAAACCCATGGGCAAGTAGTGATCTCACAA
CTGAAGTCTTTGGACTTCACTGAAAGAAAATTAAGTCAAATTGAGCATTTGCCATTAAAAGATATGGCGAAAATTGACCA
AATAATTGAATATATTTTCTAG

Antitoxin

Nucleotide

• Length: 61 bp

>AT232025 NZ_CP090879:c1467071-1467011 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Antitoxin