Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 1435233..1435756 Replicon chromosome
Accession NZ_CP090879
Organism Staphylococcus aureus strain SAUR_BFS2

Toxin (Protein)


Gene name yoeB Uniprot ID A0A2W3LFI1
Locus tag L1A04_RS06955 Protein ID WP_000074047.1
Coordinates 1435490..1435756 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A2S6D1W5
Locus tag L1A04_RS06950 Protein ID WP_000587617.1
Coordinates 1435233..1435490 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L1A04_RS06930 (1430311) 1430311..1431504 + 1194 WP_000675407.1 MFS transporter -
L1A04_RS06935 (1431728) 1431728..1432477 - 750 WP_234877926.1 CPBP family lipoprotein N-acylation protein LnsB -
L1A04_RS06940 (1432673) 1432673..1434250 + 1578 WP_000143489.1 FMN-binding glutamate synthase family protein -
L1A04_RS06945 (1434418) 1434418..1434873 - 456 WP_000732090.1 YehR family lipoprotein -
L1A04_RS06950 (1435233) 1435233..1435490 + 258 WP_000587617.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
L1A04_RS06955 (1435490) 1435490..1435756 + 267 WP_000074047.1 Txe/YoeB family addiction module toxin Toxin
L1A04_RS06960 (1436112) 1436112..1437188 + 1077 WP_001076679.1 M42 family metallopeptidase -
L1A04_RS06965 (1437534) 1437534..1438196 + 663 WP_000923514.1 ATP-binding cassette domain-containing protein -
L1A04_RS06970 (1438189) 1438189..1438965 + 777 WP_000072154.1 iron export ABC transporter permease subunit FetB -
L1A04_RS06975 (1439359) 1439359..1440546 + 1188 WP_000026190.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(4-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10662.26 Da        Isoelectric Point: 10.1384

>T232024 WP_000074047.1 NZ_CP090879:1435490-1435756 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRIVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T232024 NZ_CP127177:1721218-1721562 [Enterococcus faecalis]
ATGAAAAGTATCAAAGAGTTGGTGGAAGAATATGAAGTAGAGTTAGTTTTCGCTCCAATAAATAAGCGCGCATGTTACGA
GCCAGTCAAAAGAATAATTTTCGTAAATCAAAATTTATCTATTGAAGAACAAGAAGAGTCTATATTCCATGAGTTCAAAC
ATGTTGTTTCCCATTCGGATTACATGGAGTTATATAAAATTCCTTCTTTTAGAAATAAGATGGAATCTGAGGCAGATCAT
CATATGTTTAAATGCCTTATTGAAAAACATGATGGGCAATTTAATTATTCTAATGTGATTACCCATTACAATTTAAAGAT
GGGACAAGAAACTTATTTAAAATAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9747.71 Da        Isoelectric Point: 4.1353

>AT232024 WP_000587617.1 NZ_CP090879:1435233-1435490 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDSSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT232024 NZ_CP127177:1720877-1721200 [Enterococcus faecalis]
ATGACTGTATTTGATAGAGTTAAAAAATTAGCAGATAGTCAGAAAATATCTATTGTGGAACTTGAAGAAAAGTTAAATTT
TAGTCGAAATTCATTGTATGCTTGGAAAAAAAGCAAGCCTTCTATCGATAAATTAGAAGCTGTCGCAAATTATTTTGGAG
TTTCAACGGATTATTTATTGGGTCGTGAAATCTCTAATAAACCAAAGCAATCTGATGATTTGGATGAAATTTTAGACAAT
GTGATGAGTTTCGATGGTGAGCCTTTGGATGATCATGATCGGGAAGTTATTCGTGCTTACTTAAAAGGGAGATTCGGAAA
ATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2W3LFI1

Antitoxin

Source ID Structure
AlphaFold DB A0A2S6D1W5

References