Detailed information of TA system TA232020

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): holin-SprF1/-
• Location: 2280264..2280753
• Replicon: chromosome
• Accession: NZ_CP090877
• Organism: Staphylococcus aureus strain SAUR_BFS11

Toxin (Protein)

• Gene name: holin
• Uniprot ID: -
• Locus tag: L1A06_RS11460
• Protein ID: WP_054192796.1
• Coordinates: 2280451..2280753 (+)
• Length: 101 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	2280264..2280402 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L1A06_RS11435	2279006..2279158	+	153	WP_054192799.1	hypothetical protein	-
L1A06_RS11440	2279204..2279491	+	288	WP_031763773.1	hypothetical protein	-
L1A06_RS11445	2279547..2279921	+	375	WP_054192798.1	hypothetical protein	-
L1A06_RS11450	2280146..2280253	+	108	WP_000253687.1	putative holin-like toxin	-
-	2280264..2280402	-	139	-	-	Antitoxin
L1A06_RS11460	2280451..2280753	+	303	WP_054192796.1	phage holin	Toxin
L1A06_RS11465	2280764..2282218	+	1455	WP_054192795.1	N-acetylmuramoyl-L-alanine amidase	-
L1A06_RS11470	2282805..2283011	+	207	WP_047425008.1	hypothetical protein	-
L1A06_RS11475	2283025..2283225	+	201	WP_054192794.1	hypothetical protein	-
L1A06_RS11480	2283897..2284107	-	211	Protein_2218	hypothetical protein	-
L1A06_RS11485	2284568..2285356	-	789	WP_000206349.1	DUF1829 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	hlgA / lukD	2240315..2299592	59277

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Holin (1-68)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 11130.87 Da
• Isoelectric Point: 9.6413

>T232020 WP_054192796.1 NZ_CP090877:2280451-2280753 [Staphylococcus aureus]
MDAKVIARYIVLILALVNQFLANKGISPIPVDDETISSIILTVVALYTTYKDNPTSQEGKWANQKLKKYKAENKYRKATG
QAPIKEVMTPTNMNDSNDLG

Nucleotide

• Length: 303 bp

>T232020 NZ_CP127168:3554677-3554928 [Glutamicibacter nicotianae]
ATGTCCATCAGTGCAAGCGAAGCCCGCAAGACGCTCTTTCCATTGATTGAACAAGTCAACGATGATCGCCAAGCTGTCGA
AATCGTGTCACGCAAGGGAAATGCTGTTCTCATGGCAGCAGATGAATACGCAGCATGGCAAGAGACCGCGTACCTCTTCC
GCTCGCCAGCCAATGCCCGGCGGCTCTTGGATGCCTACGAACGTGCACGGTCAGGAATAACAGAGACCCACGAACTCGAC
TGGGACGAATAA

Antitoxin

Nucleotide

• Length: 139 bp

>AT232020 NZ_CP090877:c2280402-2280264 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCAGAAACATGTCACCCTAGTGAGCCC
GTTAAAAAGACGGTGGCTCAGTTTTGAAATTATTATAAAATAACCATTAACCGTCCAAA

Structures

Antitoxin