Detailed information of TA system TA232016

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 2280146..2280371
• Replicon: chromosome
• Accession: NZ_CP090877
• Organism: Staphylococcus aureus strain SAUR_BFS11

Toxin (Protein)

• Gene name: SprG2
• Uniprot ID: -
• Locus tag: L1A06_RS11450
• Protein ID: WP_000253687.1
• Coordinates: 2280146..2280253 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	2280264..2280371 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L1A06_RS11435 (2279006)	2279006..2279158	+	153	WP_054192799.1	hypothetical protein	-
L1A06_RS11440 (2279204)	2279204..2279491	+	288	WP_031763773.1	hypothetical protein	-
L1A06_RS11445 (2279547)	2279547..2279921	+	375	WP_054192798.1	hypothetical protein	-
L1A06_RS11450 (2280146)	2280146..2280253	+	108	WP_000253687.1	putative holin-like toxin	Toxin
- (2280264)	2280264..2280371	-	108	NuclAT_0	-	Antitoxin
- (2280264)	2280264..2280371	-	108	NuclAT_0	-	Antitoxin
- (2280264)	2280264..2280371	-	108	NuclAT_0	-	Antitoxin
- (2280264)	2280264..2280371	-	108	NuclAT_0	-	Antitoxin
L1A06_RS11455 (2280296)	2280296..2280400	-	105	WP_054192797.1	hypothetical protein	-
L1A06_RS11460 (2280451)	2280451..2280753	+	303	WP_054192796.1	phage holin	-
L1A06_RS11465 (2280764)	2280764..2282218	+	1455	WP_054192795.1	N-acetylmuramoyl-L-alanine amidase	-
L1A06_RS11470 (2282805)	2282805..2283011	+	207	WP_047425008.1	hypothetical protein	-
L1A06_RS11475 (2283025)	2283025..2283225	+	201	WP_054192794.1	hypothetical protein	-
L1A06_RS11480 (2283897)	2283897..2284107	-	211	Protein_2218	hypothetical protein	-
L1A06_RS11485 (2284568)	2284568..2285356	-	789	WP_000206349.1	DUF1829 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	hlgA / lukD	2240315..2299592	59277

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (3-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3844.80 Da
• Isoelectric Point: 10.4997

>T232016 WP_000253687.1 NZ_CP090877:2280146-2280253 [Staphylococcus aureus]
VVSIVDALNLMFSFGMFIVTLLGLVIAIVKLNHKK

Nucleotide

• Length: 108 bp

>T232016 NZ_CP127161:1460478-1460828 [Proteiniborus sp. MB09-C3]
GTGATAGTAAAGAGGGGAGATATACTTTATGCTGACCTAAGTCCTGTCATTGGTTCTGAACAGGGGGGAGTTAGGCCAGT
ATTAGTAATCCAAAATGATATTGGGAATAAATATAGTCCTACTGTAATAATTTCTGCTATTACATCACAGATTAATAAAG
CTAAGTTGCCAACACATATTGAAATCACTGCTCCAGAGTACGGGCTACCTAAGGATTCAGTAGTATTACTGGAGCAAATA
AGAACCATCGACAAAAAACGGCTTAGGGAAAAGATTGGTCACTTTGATGACGACATGATGGCTAAGGTCGATGAGTGTTT
GAAAATTAGCATAGGGCTATCAGATTATTAA

Antitoxin

Nucleotide

• Length: 108 bp

>AT232016 NZ_CP090877:c2280371-2280264 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCAGAAACATGTCACCCTAGTGAGCCCGTTAAAAAGACGGTGGCTCAGTTTTGAAATT
ATTATAAAATAACCATTAACCGTCCAAA

Structures

Antitoxin