Detailed information of TA system TA232010

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 1978230..1978508
• Replicon: chromosome
• Accession: NZ_CP090877
• Organism: Staphylococcus aureus strain SAUR_BFS11

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: L1A06_RS09650
• Protein ID: WP_001802298.1
• Coordinates: 1978230..1978334 (+)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	1978330..1978508 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L1A06_RS09635	1975026..1975808	+	783	WP_000908174.1	ABC transporter ATP-binding protein	-
L1A06_RS09640	1975876..1976733	+	858	WP_000370931.1	HAD family hydrolase	-
L1A06_RS09645	1977392..1977550	-	159	WP_001792784.1	hypothetical protein	-
L1A06_RS09650	1978230..1978334	+	105	WP_001802298.1	hypothetical protein	Toxin
-	1978330..1978508	-	179	-	-	Antitoxin
L1A06_RS09660	1979142..1980788	+	1647	WP_000277718.1	IS1182 family transposase	-
L1A06_RS09665	1980817..1981908	-	1092	WP_000495672.1	hypothetical protein	-
L1A06_RS09670	1982174..1983154	-	981	WP_000019739.1	CDF family zinc efflux transporter CzrB	-
L1A06_RS09675	1983156..1983476	-	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	1979142..1980788	1646

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T232010 WP_001802298.1 NZ_CP090877:1978230-1978334 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T232010 NZ_CP127155:c76628-76212 [Klebsiella pneumoniae subsp. pneumoniae]
GTGAACAAGACCTATATGCTCGACACCTGTATCTGCTCGTTCATCATGCGCGAGCAGCCGGAAGCCGTCCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGCGGCCAGCGCATCGTTGTCTCGGCCATCACTTATTCTGAAATGCGCTTCGGGGCCACCGGCC
CGAAGGCCTCCCCGCGCCACGTCGAGCTGGTCGACGCGTTCTGCGCCCGCCTCGATGCCATCCTGCCCTGGGATCGCGCT
GCGGTGGACGCCACCACGGAGATTAAGGTGGCGCTGCGAATGGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
CGGGCACGCCATCGCCGCCGGTGCCGTGCTGGTGACGAATAATACGCGGGAATTTGAGCGGGTACCGGGTCTTGTGCTGG
AAGACTGGGTAAGATAA

Antitoxin

Nucleotide

• Length: 179 bp

>AT232010 NZ_CP090877:c1978508-1978330 [Staphylococcus aureus]
GTGTTAAAATATATTTGTAGTAAGTAGAAGCAAAAGATGAAAATCTTTAACTCTTGAAACACAAAAAGGGCAACACTCGG
AAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAATGCCGGTCA
AAGCGAATAGAAGGTTATT

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin