Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 1661171..1661694 Replicon chromosome
Accession NZ_CP090877
Organism Staphylococcus aureus strain SAUR_BFS11

Toxin (Protein)


Gene name yoeB Uniprot ID A0A0E1VXK4
Locus tag L1A06_RS08020 Protein ID WP_000074045.1
Coordinates 1661428..1661694 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A0E1VMY7
Locus tag L1A06_RS08015 Protein ID WP_000587619.1
Coordinates 1661171..1661428 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L1A06_RS07995 (1656251) 1656251..1657444 + 1194 WP_000675406.1 MFS transporter -
L1A06_RS08000 (1657668) 1657668..1658417 - 750 WP_000072464.1 CPBP family lipoprotein N-acylation protein LnsB -
L1A06_RS08005 (1658612) 1658612..1660189 + 1578 WP_000143491.1 FMN-binding glutamate synthase family protein -
L1A06_RS08010 (1660357) 1660357..1660812 - 456 WP_000732082.1 DUF1307 domain-containing protein -
L1A06_RS08015 (1661171) 1661171..1661428 + 258 WP_000587619.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
L1A06_RS08020 (1661428) 1661428..1661694 + 267 WP_000074045.1 Txe/YoeB family addiction module toxin Toxin
L1A06_RS08025 (1662050) 1662050..1663126 + 1077 WP_001076673.1 M42 family metallopeptidase -
L1A06_RS08030 (1663374) 1663374..1664036 + 663 WP_000923529.1 ATP-binding cassette domain-containing protein -
L1A06_RS08035 (1664029) 1664029..1664805 + 777 WP_000072147.1 iron export ABC transporter permease subunit FetB -
L1A06_RS08040 (1665201) 1665201..1666388 + 1188 WP_000026194.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(9-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10632.36 Da        Isoelectric Point: 10.2519

>T232005 WP_000074045.1 NZ_CP090877:1661428-1661694 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHPYLKKTFIEIVETLKNDPYKITQSFEKLEPKYLERYSRRINLQHRVVYTIDDRNKVVLI
LSAWSHYD

Download         Length: 267 bp

>T232005 NZ_CP127153:c5099647-5098730 [Klebsiella pneumoniae subsp. pneumoniae]
ATGGATATACAGGCGCCTTATTATCGGCAGGTTGCTCTGCTAATGCAGGTTTTACCCTATGTTGCTGTCGAACGGGAATT
TGCGCTGAAAGGTGGCACTGCCATCAATCTCTTTATCCGCGATTTCCCTCGATTATCGGTGGATATCGACCTCGCCTGGG
TGCCCCTGGAAAGCAGAGCCATCGCTTTACCTCATATACGGGATGCGCTTGCACGTATTGCCGCCAATCTGCAACAACAG
GCAGGTATGAGCGCTGTATTACAAGCTAATCGTTCAGATGAGATGCGTGTCATTGTTACTACCGATAGCGCGCAAATAAA
GATAGAGGTTTCACCGGTCGCCCGGGGAACATTATATCCACCACAGGAGCGAGAAGTGGTGGGGGCGGTAGAGGACGTTT
TTGGCTATGCCAGCCTTCCAGTGGTTTCGTTGCCTGACCTCTACGGTGGAAAATTATGCGCGGCGCTGGATCGCCAGCAT
CCCAGAGATTTTTATGACGTGAAATTACTTCTTGATGCGCAGGAGCTTGACCGTCCCATTTTCAATGGGTTTATCGTGTA
TTTACTGAGCCATAATCGGCCTCTGGCTGAAGTGCTGAATCCTCGCTGGAAAGATATTGCTGAACCTTTTTACCGTGAAT
TCAGCGGGATGACATTTGAGACGATAGCCCTGGAGGAACTGACAGCAGTCCCCAACAGGATGATTGCTGCGTTAAAATCC
TGTTTCACACAACAGGATGTCGATTTTTTACTGTCATTTAAACGAGGCGAACCAGACTGGCGTTTAGCGCCGGAAATGCG
TATTCAGGATTTGCCTGCCGTGCAGTGGAAATTGCGCAATATTCATCAGATGCCAGCGATAAAACGCGCTGAGTCATTAG
ATAAACTGGAAAAGGTGCTGGCCGAGTGGCGCAGTTAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9735.76 Da        Isoelectric Point: 4.1958

>AT232005 WP_000587619.1 NZ_CP090877:1661171-1661428 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETMYLVSTGTMDKVREREKDSSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT232005 NZ_CP127153:c5100411-5099653 [Klebsiella pneumoniae subsp. pneumoniae]
ATGGCAACAAAATTAAACTGGCTGCTGCAAAACAGCGCTCCCGGAGATGTGATCCTTCAGTCCTGGTTAAGCCAGCATGC
CATCTCTCCCTCTCTGTCCTTTAAATACGCGCAAAGTGGCTGGTTAAAAAAAAGAGGCAACGGCGTATATGCGCGTGCGG
GACGTGAGCCGGAGTGGAACGATGCATTAGCATGTTTGCAAAATCAGCTTGCCGCTCCGGTGTATGTTGCGGGGCTCAGT
AGCTTAGTCTGGCAGGGCCGTTCACACTATCTACAGCTAAAACAAAACCAGTGCTGGCTTAGTGTGGAAAATAAAGCGCT
GCTGCCGAAATGGTTCAGGGAATTCCCGGGTGTGGAGTGGATAGTCATATCGGGGAAAAAACTGCCGGTGCTGGATGATA
GATACCGTGTAACGCTTGATATAAAAGGGAAAAAACTCATCGGCAGTGCGCCAGAACTGGCTGCTTACGAGTTGCTGAGC
GCGGTGCCGGGGACCCTCTCATTTAACCACGCTGCAGAGCTTTTCCAGGGGCTGGTTAATCTTAATCCTCGTAAAGTAGA
GTATCTTCTTTCCGTCAGCCAGTCCGTGCAGGCCAAGCGTTTGTATCTCTTCTTCGCCAGTTTTTACGAGCATGGCTGGC
TCAAACGAATCGATAGCCAAAAAATCGATCTGGGAGCGGGCAAGCGGCAAATCGTGGAAAATGGAAAGTTCAATGCTCAA
TACCAAATCACAGTGCCTGAACGCTTTCAAAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1VXK4

Antitoxin

Source ID Structure
AlphaFold DB A0A0E1VMY7

References