232003

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 544536..544950 Replicon chromosome
Accession NZ_CP090877
Organism Staphylococcus aureus strain SAUR_BFS11

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag L1A06_RS02665 Protein ID WP_168768259.1
Coordinates 544699..544950 (-) Length 84 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag L1A06_RS02660 Protein ID WP_168777632.1
Coordinates 544536..544709 (-) Length 58 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L1A06_RS02610 (540423) 540423..541700 - 1278 WP_031929822.1 PBSX family phage terminase large subunit -
L1A06_RS02615 (541687) 541687..542127 - 441 WP_001003271.1 terminase small subunit -
L1A06_RS02620 (542314) 542314..542733 - 420 WP_000058634.1 transcriptional regulator -
L1A06_RS02625 (542748) 542748..542894 - 147 WP_000989997.1 hypothetical protein -
L1A06_RS02630 (542895) 542895..543068 - 174 WP_070014293.1 transcriptional activator RinB -
L1A06_RS02635 (543065) 543065..543271 - 207 WP_054189015.1 DUF1381 domain-containing protein -
L1A06_RS02640 (543268) 543268..543513 - 246 WP_000120373.1 hypothetical protein -
L1A06_RS02645 (543550) 543550..544077 - 528 WP_117216027.1 dUTPase -
L1A06_RS02650 (544092) 544092..544253 - 162 WP_168777631.1 hypothetical protein -
L1A06_RS02655 (544254) 544254..544535 - 282 WP_147701981.1 hypothetical protein -
L1A06_RS02660 (544536) 544536..544709 - 174 WP_168777632.1 hypothetical protein Antitoxin
L1A06_RS02665 (544699) 544699..544950 - 252 WP_168768259.1 DUF1024 family protein Toxin
L1A06_RS02670 (544943) 544943..545251 - 309 WP_234865607.1 hypothetical protein -
L1A06_RS02675 (545248) 545248..545595 - 348 WP_000979209.1 YopX family protein -
L1A06_RS02680 (545592) 545592..545993 - 402 WP_000695762.1 hypothetical protein -
L1A06_RS02685 (546007) 546007..546249 - 243 WP_000131370.1 SAV1978 family virulence-associated passenger protein -
L1A06_RS02690 (546253) 546253..546621 - 369 WP_042903519.1 SA1788 family PVL leukocidin-associated protein -
L1A06_RS02695 (546634) 546634..547038 - 405 WP_058342511.1 RusA family crossover junction endodeoxyribonuclease -
L1A06_RS02700 (547047) 547047..547265 - 219 WP_000338530.1 hypothetical protein -
L1A06_RS02705 (547272) 547272..548156 - 885 WP_234865610.1 DnaD domain protein -
L1A06_RS02710 (548186) 548186..548656 - 471 WP_033842379.1 single-stranded DNA-binding protein -
L1A06_RS02715 (548657) 548657..549274 - 618 WP_073394849.1 MBL fold metallo-hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 510725..560396 49671


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1024

(1-81)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9303.23 Da        Isoelectric Point: 3.9756

>T232003 WP_168768259.1 NZ_CP090877:c544950-544699 [Staphylococcus aureus]
MNNREKIEQSVISASAYNGNDTEGLLKEIEDVYKKAQAFDEILEGMTNAIQHSVKEGIELDEAVGIMAGQVVYKYEEEQG
NDY

Download         Length: 252 bp

>T232003 NZ_CP127153:c4839285-4838752 [Klebsiella pneumoniae subsp. pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGTGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAAGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin


Download         Length: 58 a.a.        Molecular weight: 6482.32 Da        Isoelectric Point: 4.2484

>AT232003 WP_168777632.1 NZ_CP090877:c544709-544536 [Staphylococcus aureus]
MTISVGDKVYNHETNESLEIVQLVGDIRDTHYKLSDDSVISIIDFITKPIYLIKGDE

Download         Length: 174 bp

>AT232003 NZ_CP127153:c4839562-4839296 [Klebsiella pneumoniae subsp. pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References