Detailed information of TA system TA232002

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 2547942..2548459
• Replicon: chromosome
• Accession: NZ_CP090876
• Organism: Staphylococcus aureus strain SAUR_BFS12

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: L0998_RS12445
• Protein ID: WP_054189942.1
• Coordinates: 2548193..2548459 (+)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: L0998_RS12440
• Protein ID: WP_054189941.1
• Coordinates: 2547942..2548193 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L0998_RS12410 (2543641)	2543641..2544360	+	720	WP_054189936.1	amino acid ABC transporter permease	-
L0998_RS12415 (2544357)	2544357..2545088	+	732	WP_054189937.1	amino acid ABC transporter ATP-binding protein	-
L0998_RS12420 (2545183)	2545183..2546433	-	1251	WP_054189938.1	FemA/FemB family glycyltransferase FmhA	-
L0998_RS12425 (2546689)	2546689..2547051	+	363	WP_054189939.1	DUF4467 domain-containing protein	-
L0998_RS12430 (2547070)	2547070..2547669	+	600	WP_054189940.1	DsbA family protein	-
L0998_RS12435 (2547676)	2547676..2547777	+	102	Protein_2407	hypothetical protein	-
L0998_RS12440 (2547942)	2547942..2548193	+	252	WP_054189941.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
L0998_RS12445 (2548193)	2548193..2548459	+	267	WP_054189942.1	Txe/YoeB family addiction module toxin	Toxin
L0998_RS12450 (2548494)	2548494..2548565	+	72	WP_223200558.1	hypothetical protein	-
L0998_RS12455 (2548753)	2548753..2550300	+	1548	WP_054189943.1	zinc ABC transporter substrate-binding lipoprotein AdcA	-
L0998_RS12460 (2550486)	2550486..2550953	+	468	WP_054189944.1	SRPBCC domain-containing protein	-
L0998_RS12465 (2551040)	2551040..2551222	+	183	WP_054189945.1	hypothetical protein	-
L0998_RS12470 (2551425)	2551425..2552249	+	825	WP_000594640.1	formate/nitrite transporter family protein	-
L0998_RS12475 (2552718)	2552718..2553254	+	537	WP_054189946.1	GNAT family N-acetyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (8-88)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10393.94 Da
• Isoelectric Point: 10.0573

>T232002 WP_054189942.1 NZ_CP090876:2548193-2548459 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMALKINELLKSIDRNGALKGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Nucleotide

• Length: 267 bp

>T232002 NZ_CP127153:4226453-4226671 [Klebsiella pneumoniae subsp. pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9463.69 Da
• Isoelectric Point: 4.3407

>AT232002 WP_054189941.1 NZ_CP090876:2547942-2548193 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTIMKD
IDV

Nucleotide

• Length: 252 bp

>AT232002 NZ_CP127153:4226052-4226426 [Klebsiella pneumoniae subsp. pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG