Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2527358..2527542 Replicon chromosome
Accession NZ_CP090876
Organism Staphylococcus aureus strain SAUR_BFS12

Toxin (Protein)


Gene name SprA2 Uniprot ID A0A2K4AFL5
Locus tag L0998_RS12320 Protein ID WP_000482651.1
Coordinates 2527358..2527465 (+) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2527482..2527542 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0998_RS12295 2522725..2523198 + 474 WP_054189920.1 GyrI-like domain-containing protein -
L0998_RS12300 2523322..2524533 - 1212 WP_054189921.1 multidrug effflux MFS transporter -
L0998_RS12305 2524715..2525368 - 654 WP_054189922.1 hypothetical protein -
L0998_RS12310 2525428..2526570 - 1143 WP_054189923.1 glycerate kinase -
L0998_RS12315 2526838..2527224 + 387 WP_054189924.1 flippase GtxA -
L0998_RS12320 2527358..2527465 + 108 WP_000482651.1 type I toxin-antitoxin system Fst family toxin Toxin
- 2527482..2527542 - 61 - - Antitoxin
L0998_RS12325 2527652..2527819 + 168 Protein_2385 hypothetical protein -
L0998_RS12330 2527874..2528560 + 687 WP_054189925.1 dethiobiotin synthase -
L0998_RS12335 2528538..2529896 + 1359 WP_054189926.1 adenosylmethionine--8-amino-7-oxononanoate transaminase -
L0998_RS12340 2529898..2530905 + 1008 WP_001046647.1 biotin synthase BioB -
L0998_RS12345 2530883..2531998 + 1116 WP_054189927.1 pyridoxal phosphate-dependent aminotransferase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 3984.75 Da        Isoelectric Point: 11.0582

>T232000 WP_000482651.1 NZ_CP090876:2527358-2527465 [Staphylococcus aureus]
MFNLLINIMTSAISGCLVAFFAHWLRTRSNKKGDK

Download         Length: 108 bp

>T232000 NZ_CP127153:2008172-2008274 [Klebsiella pneumoniae subsp. pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 61 bp

>AT232000 NZ_CP090876:c2527542-2527482 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTATTGCCGTAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2K4AFL5

Antitoxin

Download structure file

References