Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2495705..2496228 Replicon chromosome
Accession NZ_CP090876
Organism Staphylococcus aureus strain SAUR_BFS12

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag L0998_RS12180 Protein ID WP_054189905.1
Coordinates 2495962..2496228 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag L0998_RS12175 Protein ID WP_020977565.1
Coordinates 2495705..2495962 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0998_RS12155 (2490784) 2490784..2491977 + 1194 WP_006191034.1 MFS transporter -
L0998_RS12160 (2492201) 2492201..2492950 - 750 WP_054189903.1 CPBP family lipoprotein N-acylation protein LnsB -
L0998_RS12165 (2493145) 2493145..2494722 + 1578 WP_054189904.1 FMN-binding glutamate synthase family protein -
L0998_RS12170 (2494890) 2494890..2495345 - 456 WP_000732082.1 DUF1307 domain-containing protein -
L0998_RS12175 (2495705) 2495705..2495962 + 258 WP_020977565.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
L0998_RS12180 (2495962) 2495962..2496228 + 267 WP_054189905.1 Txe/YoeB family addiction module toxin Toxin
L0998_RS12185 (2496582) 2496582..2497658 + 1077 WP_054189906.1 M42 family metallopeptidase -
L0998_RS12190 (2498008) 2498008..2498670 + 663 WP_025786559.1 ATP-binding cassette domain-containing protein -
L0998_RS12195 (2498663) 2498663..2499439 + 777 WP_000072151.1 iron export ABC transporter permease subunit FetB -
L0998_RS12200 (2499833) 2499833..2501020 + 1188 WP_054189907.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(9-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10587.19 Da        Isoelectric Point: 10.1603

>T231999 WP_054189905.1 NZ_CP090876:2495962-2496228 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKITHPYLKKTFIEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRGVYTIDDRNKVVLI
LSAWSHYD

Download         Length: 267 bp

>T231999 NZ_CP127153:876185-876592 [Klebsiella pneumoniae subsp. pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCGTGC
GCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCCGAA
TGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGGACA
GCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGGCGC
AGGAGTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9796.79 Da        Isoelectric Point: 4.3304

>AT231999 WP_020977565.1 NZ_CP090876:2495705-2495962 [Staphylococcus aureus]
MIITSPTEARKHFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT231999 NZ_CP127153:875938-876204 [Klebsiella pneumoniae subsp. pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References