Detailed information of TA system TA231992

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 441267..441605
• Replicon: chromosome
• Accession: NZ_CP090876
• Organism: Staphylococcus aureus strain SAUR_BFS12

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: L0998_RS02515
• Protein ID: WP_077446684.1
• Coordinates: 441267..441443 (+)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	441431..441605 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L0998_RS02495	436485..440270	+	3786	WP_000582158.1	phage tail spike protein	-
L0998_RS02500	440260..440412	+	153	WP_001153681.1	hypothetical protein	-
L0998_RS02505	440459..440746	+	288	WP_001040261.1	hypothetical protein	-
L0998_RS02510	440804..441115	+	312	WP_054190602.1	DUF2951 family protein	-
L0998_RS02515	441267..441443	+	177	WP_077446684.1	type I toxin-antitoxin system toxin PepG1	Toxin
-	441431..441605	-	175	-	-	Antitoxin
L0998_RS02525	441655..441909	+	255	WP_000611512.1	phage holin	-
L0998_RS02530	441921..442676	+	756	WP_000861038.1	CHAP domain-containing protein	-
L0998_RS02535	442867..443358	+	492	WP_000919350.1	staphylokinase	-
L0998_RS02540	444008..444343	+	336	Protein_456	SH3 domain-containing protein	-
L0998_RS02545	444853..445203	+	351	WP_000702262.1	complement inhibitor SCIN-A	-
L0998_RS02550	445256..445516	-	261	WP_001791826.1	hypothetical protein	-
L0998_RS02555	445827..446006	-	180	WP_000669789.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	hlgA / lukD / sak / scn	382615..445203	62588

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6844.44 Da
• Isoelectric Point: 9.9479

>T231992 WP_077446684.1 NZ_CP090876:441267-441443 [Staphylococcus aureus]
MDRWWLSEYKEVVPMLALLKSLERRCLMITISTMLQFGLFLIALIGLVIKFIELSNKK

Nucleotide

• Length: 177 bp

>T231992 NZ_CP127126:1886976-1887563 [Pseudomonas aeruginosa PA14]
ATGTCGAGGAGGGCGCCCATGTTCAAGCCGCTACCGATCACCCTGCAGCGCGGAGCCTTGCGTCTCGAGCCGCTGGTGGA
AGCGGACATTCCCGAGCTGGTGAGCCTTGCCGAAGCCAACCGCGAGGCGCTGCAGTACATGGACGGACCGACGCGGCCGG
ACTGGTACCGCCAGAGCCTCGCCGAGCAGCGCGAGGGCAGGGCGTTGCCGCTCGCCGTCCGCCTCGGCGTGCAACTGGTC
GGGACCACGCGCTTCGCCGAATTCCTTCCCGCCTTGCCGGCCTGCGAGATCGGCTGGACCTGGCTCGACCAGGCCCAGCA
CGGCAGCGGCCTGAACCGCATGATCAAGTACCTGATGCTCAAGCATGCCTTCGACAACCTGCGCATGGTCCGCGTGCAGC
TCAGCACGGCGGCGAGCAACCTGCGCGCCCAGGGCGCCATCGACAAGCTCGGCGCGCAGCGCGAGGGCGTGCTGCGCAAC
CACCGGCGGCTGGCCGGCGGGCGGCTAGACGACACCTTCGTCTACAGCATCACCGACCACGAATGGCCGCAGGTCAAGGC
GGCGCTGGAAGCCAGCTTCACCGGCTGA

Antitoxin

Nucleotide

• Length: 175 bp

>AT231992 NZ_CP090876:c441605-441431 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Structures

Antitoxin