Detailed information of TA system TA231982

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 1587854..1588192
• Replicon: chromosome
• Accession: NZ_CP090873
• Organism: Staphylococcus aureus strain SAUR_BFS16

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: A0A6B5C9Y4
• Locus tag: L1A02_RS07855
• Protein ID: WP_072357969.1
• Coordinates: 1587854..1588030 (+)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	1588018..1588192 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L1A02_RS07835	1583021..1586803	+	3783	WP_016170804.1	phage tail spike protein	-
L1A02_RS07840	1586796..1586948	+	153	WP_001000058.1	hypothetical protein	-
L1A02_RS07845	1586994..1587281	+	288	WP_001262620.1	hypothetical protein	-
L1A02_RS07850	1587337..1587711	+	375	WP_000340977.1	hypothetical protein	-
L1A02_RS07855	1587854..1588030	+	177	WP_072357969.1	type I toxin-antitoxin system toxin PepG1	Toxin
-	1588018..1588192	-	175	-	-	Antitoxin
L1A02_RS07865	1588242..1588496	+	255	WP_000611512.1	phage holin	-
L1A02_RS07870	1588508..1589263	+	756	WP_000861038.1	CHAP domain-containing protein	-
L1A02_RS07875	1589454..1589945	+	492	WP_000920041.1	staphylokinase	-
L1A02_RS07880	1590596..1590930	+	335	Protein_1540	SH3 domain-containing protein	-
L1A02_RS07885	1591023..1591472	-	450	WP_000727645.1	chemotaxis-inhibiting protein CHIPS	-
L1A02_RS07890	1592155..1592505	+	351	WP_000702262.1	complement inhibitor SCIN-A	-
L1A02_RS07895	1592558..1592818	-	261	WP_001791826.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	groEL / seb / hlb / sak / chp / scn	1525522..1592505	66983

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6863.47 Da
• Isoelectric Point: 10.6777

>T231982 WP_072357969.1 NZ_CP090873:1587854-1588030 [Staphylococcus aureus]
MDRWWLSEYKEVVPMLALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T231982 NZ_CP127100:852411-852764 [Staphylococcus pseudintermedius]
ATGAAGCGCGGAGACGTTTATTTAGCAGATTTATCACCAGTACAGGGCTCTGAACAGGGGGGAGTAAGGCCCGTTGTCAT
TATTCAAAATGACACTGGTAATAAGTATAGTCCCACTGTGATTGTAGCCGCAATTACTGGTCGGATTAATAAGGCAAAGA
TACCAACGCATGTCGAAATCGAAAAAAATAAATATAAGCTCGATAAAGATTCTGTTATTTTACTAGAACAAATTCGAACA
GTCGATAAGAAACGATTAAAAGAAAAGTTAACGTTTTTGTCTGAGAAGAAGATGAAAGAAGTTAACAATGCGATTGGTAT
TAGTTTAGGACTGCACATGAATCATCATAAATAG

Antitoxin

Nucleotide

• Length: 175 bp

>AT231982 NZ_CP090873:c1588192-1588018 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAGTGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Structures

Toxin

• AlphaFold DB: A0A6B5C9Y4

Antitoxin