Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/- |
| Location | 1564707..1565121 | Replicon | chromosome |
| Accession | NZ_CP090873 | ||
| Organism | Staphylococcus aureus strain SAUR_BFS16 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | - |
| Locus tag | L1A02_RS07690 | Protein ID | WP_001065046.1 |
| Coordinates | 1564707..1564958 (+) | Length | 84 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | L1A02_RS07695 | Protein ID | WP_000028424.1 |
| Coordinates | 1564948..1565121 (+) | Length | 58 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| L1A02_RS07645 (1560130) | 1560130..1561050 | + | 921 | WP_000138475.1 | recombinase RecT | - |
| L1A02_RS07650 (1561131) | 1561131..1561748 | + | 618 | WP_077517322.1 | MBL fold metallo-hydrolase | - |
| L1A02_RS07655 (1561749) | 1561749..1562219 | + | 471 | WP_000610649.1 | single-stranded DNA-binding protein | - |
| L1A02_RS07660 (1562249) | 1562249..1563089 | + | 841 | Protein_1496 | DnaD domain protein | - |
| L1A02_RS07665 (1563096) | 1563096..1563314 | + | 219 | WP_000338528.1 | hypothetical protein | - |
| L1A02_RS07670 (1563323) | 1563323..1563728 | + | 406 | Protein_1498 | RusA family crossover junction endodeoxyribonuclease | - |
| L1A02_RS07675 (1563741) | 1563741..1564109 | + | 369 | WP_023604910.1 | SA1788 family PVL leukocidin-associated protein | - |
| L1A02_RS07680 (1564113) | 1564113..1564355 | + | 243 | WP_023604909.1 | phi PVL orf 51-like protein | - |
| L1A02_RS07685 (1564364) | 1564364..1564714 | + | 351 | WP_025176279.1 | hypothetical protein | - |
| L1A02_RS07690 (1564707) | 1564707..1564958 | + | 252 | WP_001065046.1 | DUF1024 family protein | Toxin |
| L1A02_RS07695 (1564948) | 1564948..1565121 | + | 174 | WP_000028424.1 | hypothetical protein | Antitoxin |
| L1A02_RS07700 (1565122) | 1565122..1565274 | + | 153 | WP_016170781.1 | hypothetical protein | - |
| L1A02_RS07705 (1565404) | 1565404..1565565 | + | 162 | WP_000889682.1 | hypothetical protein | - |
| L1A02_RS07710 (1565580) | 1565580..1566113 | + | 534 | WP_023604907.1 | dUTPase | - |
| L1A02_RS07715 (1566150) | 1566150..1566356 | + | 207 | WP_000195794.1 | DUF1381 domain-containing protein | - |
| L1A02_RS07720 (1566353) | 1566353..1566556 | + | 204 | WP_000141180.1 | hypothetical protein | - |
| L1A02_RS07725 (1566549) | 1566549..1566785 | + | 237 | WP_000608275.1 | hypothetical protein | - |
| L1A02_RS07730 (1566778) | 1566778..1567164 | + | 387 | WP_000592202.1 | hypothetical protein | - |
| L1A02_RS07735 (1567161) | 1567161..1567310 | + | 150 | WP_000595265.1 | transcriptional activator RinB | - |
| L1A02_RS07740 (1567310) | 1567310..1567510 | + | 201 | WP_000265043.1 | DUF1514 family protein | - |
| L1A02_RS07745 (1567538) | 1567538..1567954 | + | 417 | WP_000590122.1 | hypothetical protein | - |
| L1A02_RS07750 (1568186) | 1568186..1568485 | + | 300 | WP_000988336.1 | HNH endonuclease | - |
| L1A02_RS07755 (1568615) | 1568615..1568959 | + | 345 | WP_000402904.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | groEL / seb / hlb / sak / chp / scn | 1525522..1592505 | 66983 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 84 a.a. Molecular weight: 9377.26 Da Isoelectric Point: 3.7128
>T231981 WP_001065046.1 NZ_CP090873:1564707-1564958 [Staphylococcus aureus]
MNNREQIEQSIISASAYNGNDTEGLLKEVEDVYKKAQAFDEILEGLPNAMQDALKEDIGLDEAVGIMTGQVVYKYEEEQE
NEY
MNNREQIEQSIISASAYNGNDTEGLLKEVEDVYKKAQAFDEILEGLPNAMQDALKEDIGLDEAVGIMTGQVVYKYEEEQE
NEY
Download Length: 252 bp
>T231981 NZ_CP127100:837624-837845 [Staphylococcus pseudintermedius]
ATGGAAAATGGTTATGTTAAAGTAACACAACTGACAACTGAAGCACAGCAACAACAGCTATCTGATCGTTTGCTTCGTTT
AATTGGTGTCGAGTCTGTTGCTATTGATGTGGCAACACAATCGTTGACGCTCACTTATGACACGCCAGCAAATTTGAACA
CGATAGAAAAAGAAATTTATGATGCAGGATTTCCTGTTATCCAATCACATAAAGGAGTGTAA
ATGGAAAATGGTTATGTTAAAGTAACACAACTGACAACTGAAGCACAGCAACAACAGCTATCTGATCGTTTGCTTCGTTT
AATTGGTGTCGAGTCTGTTGCTATTGATGTGGCAACACAATCGTTGACGCTCACTTATGACACGCCAGCAAATTTGAACA
CGATAGAAAAAGAAATTTATGATGCAGGATTTCCTGTTATCCAATCACATAAAGGAGTGTAA
Antitoxin
Download Length: 58 a.a. Molecular weight: 6468.29 Da Isoelectric Point: 4.2484
>AT231981 WP_000028424.1 NZ_CP090873:1564948-1565121 [Staphylococcus aureus]
MSISVGDKVYNHETNESLEIVQLVGDIRDTHYKLSDDSVISIIDFITKPIYLIKGDE
MSISVGDKVYNHETNESLEIVQLVGDIRDTHYKLSDDSVISIIDFITKPIYLIKGDE
Download Length: 174 bp
>AT231981 NZ_CP127100:837324-837611 [Staphylococcus pseudintermedius]
ATGACTGAACAAGCACATCATTCTGAAGAAATTAAACGTAACTTGAAGTCGCGTTTGAATCGTATTGAAGGCCAAGTGAA
AGCAATCAACCGAATGATTGACGAAGATGTCTATTGTGATGACGTGTTGACGCAAATTAGAGCGACACGTTCGGCTTTAA
ACAGTGTGGCGTCGCGTCTGTTAGATCATCATATGAAAGGATGCATCAAGCATAAGATTGACGCGGGACACCAAGACGAA
GCGATGGAAGAGTTATTAGTAACATTTCAAAAACTCATGAAAGATTAG
ATGACTGAACAAGCACATCATTCTGAAGAAATTAAACGTAACTTGAAGTCGCGTTTGAATCGTATTGAAGGCCAAGTGAA
AGCAATCAACCGAATGATTGACGAAGATGTCTATTGTGATGACGTGTTGACGCAAATTAGAGCGACACGTTCGGCTTTAA
ACAGTGTGGCGTCGCGTCTGTTAGATCATCATATGAAAGGATGCATCAAGCATAAGATTGACGCGGGACACCAAGACGAA
GCGATGGAAGAGTTATTAGTAACATTTCAAAAACTCATGAAAGATTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|