Detailed information of TA system TA231975

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 1401268..1401546
• Replicon: chromosome
• Accession: NZ_CP090873
• Organism: Staphylococcus aureus strain SAUR_BFS16

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: L1A02_RS06755
• Protein ID: WP_001802298.1
• Coordinates: 1401268..1401372 (+)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	1401368..1401546 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L1A02_RS06740	1398065..1398847	+	783	Protein_1317	ABC transporter ATP-binding protein	-
L1A02_RS06745	1398915..1399772	+	858	WP_000370925.1	Cof-type HAD-IIB family hydrolase	-
L1A02_RS06750	1400430..1400588	-	159	WP_001792784.1	hypothetical protein	-
L1A02_RS06755	1401268..1401372	+	105	WP_001802298.1	hypothetical protein	Toxin
-	1401368..1401546	-	179	-	-	Antitoxin
L1A02_RS06765	1401805..1402896	-	1092	WP_000495669.1	hypothetical protein	-
L1A02_RS06770	1403162..1404139	-	978	WP_000019734.1	CDF family zinc efflux transporter CzrB	-
L1A02_RS06775	1404141..1404461	-	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
L1A02_RS06780	1404613..1405278	+	666	WP_001024095.1	SDR family oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T231975 WP_001802298.1 NZ_CP090873:1401268-1401372 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T231975 NZ_CP127096:911367-911573 [Staphylococcus haemolyticus]
ATGAACTTTAGTAAAATTAGAATTAGTGAATTAAATACTGAAGAGCAAGCTAATTCGCTCCAACATAGACTTGAGAAGAT
GATAGGTGTAGATGAAGTAATTGTAGAACTAAATGACCATTTAGTTAAAATTTCTTATGAAACACCTACGAATTTAAATA
GTATTGAAAAAGAAATTTATGATGATGGTTATAAGGTATTAGGTTGA

Antitoxin

Nucleotide

• Length: 179 bp

>AT231975 NZ_CP090873:c1401546-1401368 [Staphylococcus aureus]
GTGTTAAAATATATTTGTAGTAAGTAGAAGCAAAAGATGAAAATCTTTAACTCTTGAAACACAAAAAGGGCAACACTCGG
AAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAATGCCGGTCA
AAGCGAATAGAAGGTTATT

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin