Detailed information of TA system TA231973

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 1140965..1141482
• Replicon: chromosome
• Accession: NZ_CP090873
• Organism: Staphylococcus aureus strain SAUR_BFS16

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: A0A3A3ATA4
• Locus tag: L1A02_RS05395
• Protein ID: WP_000113265.1
• Coordinates: 1141216..1141482 (+)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: L1A02_RS05390
• Protein ID: WP_234863297.1
• Coordinates: 1140965..1141216 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L1A02_RS05360 (1136663)	1136663..1137382	+	720	WP_000479576.1	amino acid ABC transporter permease	-
L1A02_RS05365 (1137379)	1137379..1138110	+	732	WP_000615461.1	amino acid ABC transporter ATP-binding protein	-
L1A02_RS05370 (1138207)	1138207..1139457	-	1251	WP_001012225.1	FemA/FemB family glycyltransferase FmhA	-
L1A02_RS05375 (1139712)	1139712..1140074	+	363	WP_000819843.1	DUF4467 domain-containing protein	-
L1A02_RS05380 (1140093)	1140093..1140692	+	600	WP_000162810.1	DsbA family protein	-
L1A02_RS05385 (1140720)	1140720..1140800	+	81	WP_223197974.1	hypothetical protein	-
L1A02_RS05390 (1140965)	1140965..1141216	+	252	WP_234863297.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
L1A02_RS05395 (1141216)	1141216..1141482	+	267	WP_000113265.1	Txe/YoeB family addiction module toxin	Toxin
L1A02_RS05400 (1141517)	1141517..1141588	+	72	Protein_1058	hypothetical protein	-
L1A02_RS05405 (1141777)	1141777..1143324	+	1548	WP_000727756.1	zinc ABC transporter substrate-binding lipoprotein AdcA	-
L1A02_RS05410 (1143510)	1143510..1143977	+	468	WP_000153347.1	SRPBCC domain-containing protein	-
L1A02_RS05415 (1144061)	1144061..1144243	+	183	WP_000230292.1	hypothetical protein	-
L1A02_RS05420 (1144460)	1144460..1145284	+	825	WP_000572038.1	formate/nitrite transporter family protein	-
L1A02_RS05425 (1145518)	1145518..1146054	+	537	WP_000169317.1	GNAT family N-acetyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-81)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10436.96 Da
• Isoelectric Point: 10.0573

>T231973 WP_000113265.1 NZ_CP090873:1141216-1141482 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNNKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Nucleotide

• Length: 267 bp

>T231973 NZ_CP127095:c2480050-2479700 [Bacillus inaquosorum]
TTGATTGTGAAACGCGGCGATGTTTATTTTGCTGATTTATCTCCTGTTGTTGGCTCAGAGCAAGGCGGGGTGCGCCCGGT
TTTAGTGATCCAAAATGACATCGGAAATCGCTTCAGCCCAACTGCTATTGTTGCAGCCATAACAGCACAAATACAGAAAG
CGAAATTACCAACCCACGTCGAAATCGATGCAAAACGCTACGGTTTTGAAAGAGATTCCGTTATTTTGCTGGAGCAAATT
CGGACGATTGACAAGCAAAGATTAACGGATAAGATTACTCATCTGGATGATGAAATGATGGATAAGGTTGATGAAGCCTT
ACAAATCAGTTTGGCACTCATTGATTTTTAG

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9403.58 Da
• Isoelectric Point: 4.3407

>AT231973 WP_234863297.1 NZ_CP090873:1140965-1141216 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTIAKD
IDV

Nucleotide

• Length: 252 bp

>AT231973 NZ_CP127095:c2480336-2480055 [Bacillus inaquosorum]
TTGTCTGAATCCAGCGCAAGAACCGAAATGAAAATCAGCTTGCCCGAAAACCTAGTAGCTGAATTGGATGGTGTAGCGAT
GCGGGAGAAACGAAGCAGAAACGAACTGATATCACAAGCAGTGAGAGCGTATGTCAGCGAACGAACAACTCGTCACAACC
GTGATTTGATGAGACGCGGCTATATGGAAATGGCGAAAATCAACCTGAATATTTCTTCTGAGGCTCACTTTGCGGAGTGC
GAGGCTGAAACGACAGTTGAGCGCTTAGTCAGCGGAGGATAA

Structures

Toxin

• PDB: 7BWF