Detailed information of TA system TA231969

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 901250..901767
• Replicon: chromosome
• Accession: NZ_CP090870
• Organism: Staphylococcus aureus strain SAUR_BFS62

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: A0A3A3ATA4
• Locus tag: L0999_RS04915
• Protein ID: WP_000113265.1
• Coordinates: 901250..901516 (-)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: L0999_RS04920
• Protein ID: WP_234863297.1
• Coordinates: 901516..901767 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L0999_RS04885 (896678)	896678..897214	-	537	WP_000169317.1	GNAT family N-acetyltransferase	-
L0999_RS04890 (897448)	897448..898272	-	825	WP_000572038.1	formate/nitrite transporter family protein	-
L0999_RS04895 (898489)	898489..898671	-	183	WP_000230292.1	hypothetical protein	-
L0999_RS04900 (898755)	898755..899222	-	468	WP_000153347.1	SRPBCC domain-containing protein	-
L0999_RS04905 (899408)	899408..900955	-	1548	WP_000727756.1	zinc ABC transporter substrate-binding lipoprotein AdcA	-
L0999_RS04910 (901144)	901144..901215	-	72	Protein_929	hypothetical protein	-
L0999_RS04915 (901250)	901250..901516	-	267	WP_000113265.1	Txe/YoeB family addiction module toxin	Toxin
L0999_RS04920 (901516)	901516..901767	-	252	WP_234863297.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
L0999_RS04925 (901932)	901932..902012	-	81	WP_223197974.1	hypothetical protein	-
L0999_RS04930 (902040)	902040..902639	-	600	WP_000162810.1	DsbA family protein	-
L0999_RS04935 (902658)	902658..903020	-	363	WP_000819843.1	DUF4467 domain-containing protein	-
L0999_RS04940 (903275)	903275..904525	+	1251	WP_001012225.1	FemA/FemB family glycyltransferase FmhA	-
L0999_RS04945 (904622)	904622..905353	-	732	WP_000615461.1	amino acid ABC transporter ATP-binding protein	-
L0999_RS04950 (905350)	905350..906069	-	720	WP_000479576.1	amino acid ABC transporter permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-81)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10436.96 Da
• Isoelectric Point: 10.0573

>T231969 WP_000113265.1 NZ_CP090870:c901516-901250 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNNKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Nucleotide

• Length: 267 bp

>T231969 NZ_CP127050:8908-9186 [Pseudomonas amygdali pv. lachrymans]
ATGCAAATCATCTGGCGGCAACGTGCGCGCATGAGCCTGGCTAAGATCATCCGATATATCTCCAACGAAGACCCGCAAGC
CGCCCAAGCCATTCTGGAACGCTTACAGTCGGCCATATTGCCGGTGGCCGATCATCCATACCTGTATCGGCCTGGGCGAG
TGCCTGGCACTCGCGAGCTGGTGGCCCATCCAAACTACGTGCTGGTCTACCGCGTCACCTTAGAGCGTATTGAGGTTGTG
AACGTCATCCACGCTAGGCAGGAATACCCCTCACTCTAG

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9403.58 Da
• Isoelectric Point: 4.3407

>AT231969 WP_234863297.1 NZ_CP090870:c901767-901516 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTIAKD
IDV

Nucleotide

• Length: 252 bp

>AT231969 NZ_CP127050:8708-8908 [Pseudomonas amygdali pv. lachrymans]
ATGGCCAACCTCTCACCAATAGTTTCCGAGTTTGAAACAGACGAGCAAGCCGCTAGCTACGACCGCTGGTTTCGGCTCCA
GGTGCAAGCGTCATTGGACGATCCTAGGCCGGGAGTGCCGCACGATCAGGTCATGGCGGAAATGGCCGCAATCATCGCCG
AGGCAGAAAAGTTTCAACAGGATCGGGCTAAGGTCAACTGA

Structures

Toxin

• PDB: 7BWF