Detailed information of TA system TA231967

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 641248..641464
• Replicon: chromosome
• Accession: NZ_CP090870
• Organism: Staphylococcus aureus strain SAUR_BFS62

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: L0999_RS03555
• Protein ID: WP_001802298.1
• Coordinates: 641360..641464 (-)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	641248..641303 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L0999_RS03530	637454..638119	-	666	WP_001024095.1	SDR family oxidoreductase	-
L0999_RS03535	638271..638591	+	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
L0999_RS03540	638593..639570	+	978	WP_000019734.1	CDF family zinc efflux transporter CzrB	-
L0999_RS03545	639836..640927	+	1092	WP_000495669.1	hypothetical protein	-
-	641248..641303	+	56	-	-	Antitoxin
L0999_RS03555	641360..641464	-	105	WP_001802298.1	hypothetical protein	Toxin
L0999_RS03560	641981..642151	+	171	WP_001792292.1	transposase	-
L0999_RS03565	642144..642302	+	159	WP_001792784.1	hypothetical protein	-
L0999_RS03570	642960..643817	-	858	WP_000370925.1	Cof-type HAD-IIB family hydrolase	-
L0999_RS03575	643885..644667	-	783	Protein_670	ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-90)

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T231967 WP_001802298.1 NZ_CP090870:c641464-641360 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T231967 NZ_CP127048:c13511-13230 [Pseudomonas amygdali pv. lachrymans]
ATGCTGCCGGTGGTCTGGCTCAGTCCCGCACTGGATGATCTGCGCGAAATCGCAACCTACATCGCATGGGAAAACCCGAG
CGCAGCGCGCCGGTTGAAAAGCCTCCTGCAGGAGGCTATCGAGCCGGTAGCCGAACATCCCTATTTATATCGTTCTGGGC
GAGCGCCAGGCACTCGCGAGCTGGTGGCTCACCCAAACTACGTCCTGGTCTATCGTGTCACCCTCAAGCGCATCGAGGTC
GTGAACGTGATCCACGCCAGACAGGAATACCCCTCTCCCTGA

Antitoxin

Nucleotide

• Length: 56 bp

>AT231967 NZ_CP090870:641248-641303 [Staphylococcus aureus]
AAAAAGGGCAACACTCGGAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin