Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 477611..478025 Replicon chromosome
Accession NZ_CP090870
Organism Staphylococcus aureus strain SAUR_BFS62

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag L0999_RS02620 Protein ID WP_001065046.1
Coordinates 477774..478025 (-) Length 84 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag L0999_RS02615 Protein ID WP_000028424.1
Coordinates 477611..477784 (-) Length 58 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0999_RS02555 (473773) 473773..474117 - 345 WP_000402904.1 hypothetical protein -
L0999_RS02560 (474247) 474247..474546 - 300 WP_000988336.1 HNH endonuclease -
L0999_RS02565 (474778) 474778..475194 - 417 WP_000590122.1 hypothetical protein -
L0999_RS02570 (475222) 475222..475422 - 201 WP_000265043.1 DUF1514 family protein -
L0999_RS02575 (475422) 475422..475571 - 150 WP_000595265.1 transcriptional activator RinB -
L0999_RS02580 (475568) 475568..475954 - 387 WP_000592202.1 hypothetical protein -
L0999_RS02585 (475947) 475947..476183 - 237 WP_000608275.1 hypothetical protein -
L0999_RS02590 (476176) 476176..476379 - 204 WP_000141180.1 hypothetical protein -
L0999_RS02595 (476376) 476376..476582 - 207 WP_000195794.1 DUF1381 domain-containing protein -
L0999_RS02600 (476619) 476619..477152 - 534 WP_023604907.1 dUTPase -
L0999_RS02605 (477167) 477167..477328 - 162 WP_000889682.1 hypothetical protein -
L0999_RS02610 (477458) 477458..477610 - 153 WP_016170781.1 hypothetical protein -
L0999_RS02615 (477611) 477611..477784 - 174 WP_000028424.1 hypothetical protein Antitoxin
L0999_RS02620 (477774) 477774..478025 - 252 WP_001065046.1 DUF1024 family protein Toxin
L0999_RS02625 (478018) 478018..478368 - 351 WP_025176279.1 hypothetical protein -
L0999_RS02630 (478377) 478377..478619 - 243 WP_023604909.1 phi PVL orf 51-like protein -
L0999_RS02635 (478623) 478623..478991 - 369 WP_023604910.1 SA1788 family PVL leukocidin-associated protein -
L0999_RS02640 (479004) 479004..479409 - 406 Protein_488 RusA family crossover junction endodeoxyribonuclease -
L0999_RS02645 (479418) 479418..479636 - 219 WP_000338528.1 hypothetical protein -
L0999_RS02650 (479643) 479643..480483 - 841 Protein_490 DnaD domain protein -
L0999_RS02655 (480513) 480513..480983 - 471 WP_000610649.1 single-stranded DNA-binding protein -
L0999_RS02660 (480984) 480984..481601 - 618 WP_077517322.1 MBL fold metallo-hydrolase -
L0999_RS02665 (481682) 481682..482602 - 921 WP_000138475.1 recombinase RecT -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - scn / chp / sak / hlb / seb / groEL 450227..517210 66983


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1024

(1-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9377.26 Da        Isoelectric Point: 3.7128

>T231963 WP_001065046.1 NZ_CP090870:c478025-477774 [Staphylococcus aureus]
MNNREQIEQSIISASAYNGNDTEGLLKEVEDVYKKAQAFDEILEGLPNAMQDALKEDIGLDEAVGIMTGQVVYKYEEEQE
NEY

Download         Length: 252 bp

>T231963 NZ_CP127045:304342-304524 [Pseudomonas amygdali pv. lachrymans]
ATGAAGTGCAACGAGTTTCGGCGATGGTTGCAGGCTCAAGGCGCTGAGTTCAGGGCTGCCAAGGGTAGTCATTTCAAGGT
TTACCTGAATGGTAAGGCAACCATCTTTGCAGACCATGGAAGCAAAGAAATGCACGAAGGGTTACGCAAGTCGATCATCA
AGCAGCTCGGCCTTAAGGATTGA

Antitoxin


Download         Length: 58 a.a.        Molecular weight: 6468.29 Da        Isoelectric Point: 4.2484

>AT231963 WP_000028424.1 NZ_CP090870:c477784-477611 [Staphylococcus aureus]
MSISVGDKVYNHETNESLEIVQLVGDIRDTHYKLSDDSVISIIDFITKPIYLIKGDE

Download         Length: 174 bp

>AT231963 NZ_CP127045:304556-304981 [Pseudomonas amygdali pv. lachrymans]
ATGTATCAATATCCATTGGATCTACATCGGGAGCCGACAGGCGTTTGGCTGTCGTGTCCAGACATTCCCGAAATGAGCGC
CTCTGGCGACACCCTGCCTGAAGCATTTAGCGAAGCTCTTGACGGCATGGAATCGGCTCTATCGCTCTACGTCGATCAGC
GTCGCAAGATTCCCCAAGCCTCAGTCGTACCCGGCCATGAACTGTTGATGCGTTTGCCTGCGCTGACGGTTGCCAAAATC
ATGCTATGGAACAGCTTGTTGGAAGAGGGCGTTAGCCGTGCTGAGCTGGCGCGTCGCCTCGGTTGCACGCGGCAAGTGGT
GGATCGGCTTGTGGACTTTCTGCATGCCTCGAAAATCGAGCAGGTGGAGCGAGCGCTGGCTGAGCTTGGTCGGCGTATTA
CGTTGAGCATTGAGCGGGCCGCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References