Detailed information of TA system TA231960

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 454571..454878
• Replicon: chromosome
• Accession: NZ_CP090870
• Organism: Staphylococcus aureus strain SAUR_BFS62

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: A0A6B5C9Y4
• Locus tag: L0999_RS02455
• Protein ID: WP_072357969.1
• Coordinates: 454702..454878 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	454571..454710 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L0999_RS02415 (449914)	449914..450174	+	261	WP_001791826.1	hypothetical protein	-
L0999_RS02420 (450227)	450227..450577	-	351	WP_000702262.1	complement inhibitor SCIN-A	-
L0999_RS02425 (451260)	451260..451709	+	450	WP_000727645.1	chemotaxis-inhibiting protein CHIPS	-
L0999_RS02430 (451802)	451802..452136	-	335	Protein_446	SH3 domain-containing protein	-
L0999_RS02435 (452787)	452787..453278	-	492	WP_000920041.1	staphylokinase	-
L0999_RS02440 (453469)	453469..454224	-	756	WP_000861038.1	CHAP domain-containing protein	-
L0999_RS02445 (454236)	454236..454490	-	255	WP_000611512.1	phage holin	-
L0999_RS02450 (454542)	454542..454649	+	108	WP_031762631.1	hypothetical protein	-
- (454571)	454571..454710	+	140	NuclAT_0	-	Antitoxin
- (454571)	454571..454710	+	140	NuclAT_0	-	Antitoxin
- (454571)	454571..454710	+	140	NuclAT_0	-	Antitoxin
- (454571)	454571..454710	+	140	NuclAT_0	-	Antitoxin
L0999_RS02455 (454702)	454702..454878	-	177	WP_072357969.1	type I toxin-antitoxin system toxin PepG1	Toxin
L0999_RS02460 (455021)	455021..455395	-	375	WP_000340977.1	hypothetical protein	-
L0999_RS02465 (455451)	455451..455738	-	288	WP_001262620.1	hypothetical protein	-
L0999_RS02470 (455784)	455784..455936	-	153	WP_001000058.1	hypothetical protein	-
L0999_RS02475 (455929)	455929..459711	-	3783	WP_016170804.1	phage tail spike protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / chp / sak / hlb / seb / groEL	450227..517210	66983

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6863.47 Da
• Isoelectric Point: 10.6777

>T231960 WP_072357969.1 NZ_CP090870:c454878-454702 [Staphylococcus aureus]
MDRWWLSEYKEVVPMLALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T231960 NZ_CP127024:c2364443-2364234 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATAGATGGTCAAGTAACTGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin

Nucleotide

• Length: 140 bp

>AT231960 NZ_CP090870:454571-454710 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAGTGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Structures

Toxin

• AlphaFold DB: A0A6B5C9Y4

Antitoxin