Detailed information of TA system TA231908

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 3780868..3781543
• Replicon: chromosome
• Accession: NZ_CP090792
• Organism: Enterobacter hormaechei strain FY-1

Toxin (Protein)

• Gene name: higB
• Uniprot ID: A0A7T9SGM4
• Locus tag: L0Y16_RS18120
• Protein ID: WP_032654718.1
• Coordinates: 3780868..3781167 (+)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: L0Y16_RS18125
• Protein ID: WP_032654721.1
• Coordinates: 3781178..3781543 (+)
• Length: 122 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L0Y16_RS18110 (L0Y16_18110)	3777245..3779437	+	2193	WP_032654716.1	type I secretion system permease/ATPase	-
L0Y16_RS18115 (L0Y16_18115)	3779418..3780617	+	1200	WP_017382757.1	HlyD family efflux transporter periplasmic adaptor subunit	-
L0Y16_RS18120 (L0Y16_18120)	3780868..3781167	+	300	WP_032654718.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
L0Y16_RS18125 (L0Y16_18125)	3781178..3781543	+	366	WP_032654721.1	HigA family addiction module antitoxin	Antitoxin
L0Y16_RS18130 (L0Y16_18130)	3781570..3782751	-	1182	WP_017382758.1	PLP-dependent aminotransferase family protein	-
L0Y16_RS18135 (L0Y16_18135)	3782772..3783659	-	888	WP_032654725.1	LysR substrate-binding domain-containing protein	-
L0Y16_RS18140 (L0Y16_18140)	3783757..3784359	+	603	WP_032654728.1	short chain dehydrogenase	-
L0Y16_RS18145 (L0Y16_18145)	3784356..3785087	-	732	WP_017382760.1	methyltransferase domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (1-95)

Antitoxin

• Cro/C1-type helix-turn-helix domain (20-71)

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11582.25 Da
• Isoelectric Point: 9.8425

>T231908 WP_032654718.1 NZ_CP090792:3780868-3781167 [Enterobacter hormaechei]
MINHYRDQWLEDFFLYGRSSNVIPLNLETALARKLDIINAAMSHLDLRSPPGNMYEALSPPLKGYSSIRVNRQYRLVFRW
SAGKADDLYLSPHKYTQHK

Nucleotide

• Length: 300 bp

>T231908 NZ_CP126994:1293663-1294055 [Acidisoma sp. PAMC 29798]
GTGATATACCTGCTCGACAGCAATGCCGTGATCGCTCTCTTCGCCGGCCATCTCGGCTTCATCACGCGTCTCAAGCACCA
TCGACCGACAGACGTCGGCCTGTCGTCCATCGTCGCCCATGAGTTGTATTTCGGTGCCTATAAAAGCCGTAAACAGGCTG
AAAACTTGGCGCGGGTGGAGGCTCACCTTTTTGAGGTCCTCCCTTTCGATCAGCAGGATGCGCGCCAAGCAGGCGAATTG
CGCGCCGCGCTATCCGTGTCGGGCACGCCAATCGGTCCCTATGACGTACTGATCGCCGGTCAGGCGCTGGCCAAAGGCTT
GACGCTGATCACCCGCAACCTGCGCGAATTCGAGCGGGTGCCAAGCCTGCTGGTCGAGAACTGGGAAGTCTAG

Antitoxin

Protein

• Length: 122 a.a.
• Molecular weight: 13731.81 Da
• Isoelectric Point: 9.5936

>AT231908 WP_032654721.1 NZ_CP090792:3781178-3781543 [Enterobacter hormaechei]
MTLQQALRKPTTPGEVLQYEYLEPLNLKINDLAEMLNVHRNTVSALVNNNRKLTADMAIKLAKAFNTTIEFWLNLQLNVD
IWEAQSNSRTQEELSRIKTVAEVMAKRKLGKPDVTLHGNSA

Nucleotide

• Length: 366 bp

>AT231908 NZ_CP126994:1293424-1293666 [Acidisoma sp. PAMC 29798]
ATGGACATCGCCAAGATTTTCTGGTCTGGCCGCTCCCAGGCGGTGCGTCTTCCCAAGGAATATCGGTTCGATGTTGGCGA
GGTGCGCATTCGACGGCAGGGCAACGCGCTTGTTCTAGAGCCGGTTCCACGAGACTGGGCGTGGCTCGATGGGGTTACCG
GGCCTTTGGACGCGGATTTTGTCGAGGCCGTGGGTGAGCAGCCGCCGGAGCAGGTGCGGCCTGACCTTGATTTCTTCGAG
TGA

Structures

Toxin

• AlphaFold DB: A0A7T9SGM4